... intake during pregnancy was assessed using a validated food frequency questionnaire. Additionally, DNA samples were genotyped for PEMT rs7946 (G5465A) with plasma homocysteine (Hcy) levels measured. Results: Compared with the lowest quartile of choline intake, women within the highest consumption...

... stress status and endothelial dysfunction. Few data have been provided on the impact of diabetes on homocysteine and its relationship with the prevalence and extent of CAD in this high-risk subset of patients and therefore, this is the aim of this study. Methods: Our population is represented...

...Fang-Pei Chen; Hwei-Ming Wang; Feng-Fan Chiang; Chun-Che Lin; Shih-Chien Huang; Yi-Chia Huang Background/Aims: The links between the metabolic syndrome and homocysteine in relation to the risk of colorectal polyps are not understood. The purpose of this study was to investigate the association...

... (<200 pg/ml, n = 857), borderline (201-350 pg/ml, n = 382) and normal vitamin B 12 level (>350 pg/ml, n = 1,608) were 30.1, 13.4 and 56.5%, respectively. Of the 382 subjects who had borderline vitamin B 12 level, 61 subjects had both increased total homocysteine (tHcy; >13 µmol/l) and low...

... of alcohol consumption. Hyperhomocysteinemia is considered an independent risk factor for liver diseases, and the genetic polymorphisms C677T and A1298C in the MTHFR gene have been linked to hyperhomocysteinemia. The purpose of this study was to investigate serum homocysteine (Hcy) concentrations...

... of the present study was to investigate associations between folate intake, red blood cell (RBC) folate, total homocysteine (tHcy) and the MTHFR 677T allele. Methods: A total of 204 women were enrolled in a cross-sectional study. Folate intake was assessed by a food frequency questionnaire, and RBC folate, tHcy...

...Thaís Tobaruela Ortiz; Maria Teresa Terreri; Michelle Caetano; Fabíola Suano Souza; Vânia D'Almeida; Roseli Oselka Saccardo Sarni; Maria Odete Esteves Hilário Objective: To evaluate the presence of dyslipidemia and plasma concentrations of homocysteine (Hcy) and cysteine (Cys) in adolescents...

... in the lipid profile, fasting glycaemia, high arterial pressure values, oxidative stress, increased intima media thickness and impaired endothelium-dependent vasodilation) in prepubertal children with elevated homocysteine (Hcy) levels. Methods: In a cross-sectional study, 35 children with Hcy levels ≥7.3 μmol...

...Roberta Schein Bigio; Eliseu Verly Jr; Michelle Alessandra de Castro; Chester Luis Galvão Cesar; Regina Mara Fisberg; Dirce Maria Lobo Marchioni Background: Folate, a B vitamin, has been associated with a reduced concentration of plasma homocysteine (phcy), a marker of cardiovascular disease...

...)]. Results: Low plasma vitamin B 12 concentration was observed in 51.1% of the women, while 42.4% had impaired B 12 status. Elevated MMA, elevated homocysteine (>10 µmol/l) and low erythrocyte folate (<283 nmol/l) were observed among 75.8, 43.3 and 22.2% of the women, respectively. The median (25th...

...-carbon metabolism and are reported to underlie intrauterine programming of adult diseases. Methods: In the present study, the levels of folate, vitamin B 12 and homocysteine were measured in mothers delivering preterm (PT; gestation <37 weeks; n = 67), those delivering preterm due to preeclampsia (PT...

...Johanna Breilmann; Jörn Pons-Kühnemann; Christiane Brunner; Margrit Richter; Monika Neuhäuser-Berthold Background: The factors influencing total plasma homocysteine levels (tHcy) are of special interest in the attempt to reduce cardiovascular risk. Aim: This investigation aimed to assess...

...Alexander Semmler; Susan Farmand; Susanna Moskau; Birgit Stoffel-Wagner; Michael Linnebank Background/Aim: Recent studies have suggested a relation of homocysteine with lipid metabolism. The aim of this study was to analyze a possible genetic basis for such a relation in 504 individuals including...

... days. Biomarkers of methionine metabolism and antioxidant status were evaluated. Results: Serum total homocysteine concentration increased (p < 0.01) in FA deficient animals, with no differences between the supplemented groups. The hepatic ‘methylation ratio’ (S-adenosylmethionine/S...

...Rafael Deminice; Guilherme Vannucchi Portari; Julio Sergio Marchini; Helio Vannucchi; Alceu Afonso Jordao Background/Aims: Transmethylation reactions and antioxidant metabolism are linked by transsulfuration, where homocysteine (Hcy) is converted to cysteine and reduced glutathione (GSH). Low...

... with folate deficiency, increased homocysteine levels but did not induce the expression of the inflammation markers evaluated. Conclusion: Under the study conditions, methionine was not able to exert the atherogenic mechanism proposed and did not have the hypothesized inflammatory consequences in human aortic...

... dietary intake of folate and vitamin B 12 and to determine blood concentrations of folate, vitamin B 12 and homocysteine in women of childbearing age as baseline data regarding folic acid fortification in Iran. Methods: A descriptive cross-sectional survey was performed with 579 healthy women...

...José F. Cascalheira; Mónica C. Parreira; Andreza N. Viegas; Maria C. Faria; Fernanda C. Domingues Background/Aim: High serum levels of homocysteine and cortisol are independent risk factors for several pathologies and their levels can be regulated by some vitamins. Since the relationship between...

...Jasmin Al-Tahan; Ricardo Sola; Jonatan R. Ruiz; Christina Breidenassel; Miguel García-Fuentes; Luis A. Moreno; Manuel Castillo; Klaus Pietrzik; Marcela González-Gross Background: Folate and cobalamin are responsible for healthy growth. However, the B-vitamin and homocysteine status of adolescents...

...Alfons Ramel; Palmi V. Jonsson; Sigurbjorn Bjornsson; Inga Thorsdottir Aims: To describe the prevalence of hyperhomocystein- emia (>15 µmol/l) in hospitalized elderly and to investigate whether nutrition status and other factors are related to total plasma homocysteine (tHcy). Methods: Sixty...