Objective: The aim of this study was to compare the effects of low-volume, high-intensity interval training (HIIT) or moderate-intensity continuous training (MICT) on body composition in adults with metabolic syndrome (MS). Methods: This is a post hoc analysis of the randomized clinical trial Intraining-MET. Sixty adults (40–60 years old) were randomized to an MICT (n = 31) or HIIT (n = 29) supervised programme 3 days/week for 12 weeks. MICT sessions were conducted for 36 min at 60% of peak oxygen consumption (VO2peak). HIIT sessions included 6 intervals at 90% VO2peak for 1 min, followed by 2 min at 50% VO2peak. Body composition was assessed with dual energy X-ray absorptiometry. Results: Body weight did not change from pre- to post-training in either MICT (78.9 ± 15.6 kg; 77.7 ± 16.5 kg, p = 0.280) or HIIT groups (76.3 ± 13.4 kg; 76.3 ± 13.7 kg, p = 0.964). Body fat percentage and fat mass (FM) decreased post-training in the MICT (−0.9%; 95% confidence interval [CI]: −0.27 to −1.47 and −0.7 kg; 95% CI: −0.12 to −1.30) and HIIT groups (−1.0%; 95% CI: −0.32 to −1.68 and −0.8 kg; 95% CI: −0.17 to −1.47). Compared to the HIIT programme, MICT significantly reduced android FM (−0.14 kg; 95% CI: −0.02 to −0.26). Lean mass (LM) increased post-training in MICT (+0.7 kg; 95% CI: 0.01–1.41) and HIIT groups (+0.9 kg; 95% CI: 0.12–1.64), but only HIIT increased the trunk LM (+0.6 kg; 95% CI: 0.06–1.20). Conclusions: Both MICT and HIIT reduced FM without changing body weight in adults with MS. MICT had additional benefits by reducing the android FM, whereas HIIT seemed to increase LM. Given the characteristics of the post hoc analysis, further research is required to confirm these results.

1.
Donnelly
JE
,
Blair
SN
,
Jakicic
JM
,
Manore
MM
,
Rankin
JW
,
Smith
BK
.
American College of Sports Medicine Position Stand. Appropriate physical activity intervention strategies for weight loss and prevention of weight regain for adults
.
Med Sci Sports Exerc
.
2009
;
41
(
2
):
459
71
.
2.
Washburn
RA
,
Szabo
AN
,
Lambourne
K
,
Willis
EA
,
Ptomey
LT
,
Honas
JJ
,
Does the method of weight loss effect long-term changes in weight, body composition or chronic disease risk factors in overweight or obese adults? A systematic review
.
PLoS One
.
2014
;
9
(
10
):
e109849
. .
3.
De Nardi
AT
,
Tolves
T
,
Lenzi
TL
,
Signori
LU
,
da Silva
AMV
.
High-intensity interval training versus continuous training on physiological and metabolic variables in prediabetes and type 2 diabetes: a meta-analysis
.
Diabetes Res Clin Pract
.
2018
;
137
:
149
59
. .
4.
Maturana
FM
,
Martus
P
,
Zipfel
S
,
Nieß
AM
.
Effectiveness of HIIE versus MICT in improving cardiometabolic risk factors in health and disease: a meta-analysis
.
Med Sci Sports Exerc
.
2021
;
53
(
3
):
559
73
.
5.
Keating
SE
,
Johnson
NA
,
Mielke
GI
,
Coombes
JS
.
A systematic review and meta-analysis of interval training versus moderate-intensity continuous training on body adiposity
.
Obes Rev
.
2017
;
18
(
8
):
943
64
. .
6.
Maillard
F
,
Pereira
B
,
Boisseau
N
.
Effect of high-intensity interval training on total, abdominal and visceral fat mass: a meta-analysis
.
Sports Med
.
2018
;
48
(
2
):
269
88
.
7.
Morales-Palomo
F
,
Ramirez-Jimenez
M
,
Ortega
JF
,
Mora-Rodriguez
R
.
Effectiveness of aerobic exercise programs for health promotion in metabolic syndrome
.
Med Sci Sports Exerc
.
2019
;
51
(
9
):
1876
. .
8.
Ramos
JS
,
Dalleck
LC
,
Borrani
F
,
Mallard
AR
,
Clark
B
,
Keating
SE
,
The effect of different volumes of high-intensity interval training on proinsulin in participants with the metabolic syndrome: a randomised trial
.
Diabetologia
.
2016
;
59
(
11
):
2308
20
. .
9.
Matsuo
T
,
So
R
,
Shimojo
N
,
Tanaka
K
.
Effect of aerobic exercise training followed by a low-calorie diet on metabolic syndrome risk factors in men
.
Nutr Metab Cardiovasc Dis
.
2015
;
25
(
9
):
832
8
. .
10.
Dun
Y
,
Thomas
RJ
,
Smith
JR
,
Medina-Inojosa
JR
,
Squires
RW
,
Bonikowske
AR
,
High-intensity interval training improves metabolic syndrome and body composition in outpatient cardiac rehabilitation patients with myocardial infarction
.
Cardiovasc Diabetol
.
2019
;
18
(
1
):
104
. .
11.
Serrablo-Torrejon
I
,
Lopez-Valenciano
A
,
Ayuso
M
,
Horton
E
,
Mayo
X
,
Medina-Gomez
G
,
High intensity interval training exercise-induced physiological changes and their potential influence on metabolic syndrome clinical biomarkers: a meta-analysis
.
BMC Endocr Disord
.
2020
;
20
(
1
):
167
. .
12.
Zhang
H
,
Tong
TK
,
Qiu
W
,
Zhang
X
,
Zhou
S
,
Liu
Y
,
Comparable effects of high-intensity interval training and prolonged continuous exercise training on abdominal visceral fat reduction in obese young women
.
J Diabetes Res
.
2017
;
2017
:
5071740
. .
13.
Callahan
MJ
,
Parr
EB
,
Hawley
JA
,
Camera
DM
.
Can high-intensity interval training promote skeletal muscle anabolism?
Sports Med
.
2021
;
51
(
3
):
405
21
. .
14.
Londono
FJ
,
Calderon
JC
,
Gallo
J
.
Association between thigh muscle development and the metabolic syndrome in adults
.
Ann Nutr Metab
.
2012
;
61
(
1
):
41
6
.
15.
Blue
MNM
,
Smith-Ryan
AE
,
Trexler
ET
,
Hirsch
KR
.
The effects of high intensity interval training on muscle size and quality in overweight and obese adults
.
J Sci Med Sport
.
2018
;
21
(
2
):
207
12
. .
16.
Myers
J
,
Kokkinos
P
,
Nyelin
E
.
Physical activity, cardiorespiratory fitness, and the metabolic syndrome
.
Nutrients
.
2019
;
11
(
7
):
1652
. .
17.
Gallo-Villegas
J
,
Aristizabal
JC
,
Estrada
M
,
Valbuena
LH
,
Narvaez-Sanchez
R
,
Osorio
J
,
Efficacy of high-intensity, low-volume interval training compared to continuous aerobic training on insulin resistance, skeletal muscle structure and function in adults with metabolic syndrome: study protocol for a randomized controlled clinical trial (Intraining-MET)
.
Trials
.
2018
;
19
(
1
):
144
. .
18.
Higgins
S
,
Fedewa
MV
,
Hathaway
ED
,
Schmidt
MD
,
Evans
EM
.
Sprint interval and moderate-intensity cycling training differentially affect adiposity and aerobic capacity in overweight young-adult women
.
Appl Physiol Nutr Metab
.
2016
;
41
(
11
):
1177
83
. .
19.
Alberti
KG
,
Eckel
RH
,
Grundy
SM
,
Zimmet
PZ
,
Cleeman
JI
,
Donato
KA
,
Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation task force on epidemiology and prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity
.
Circulation
.
2009
;
120
(
16
):
1640
5
.
20.
Fiona
CB
,
Tahlia
SM
,
Timothy
A
.
Global physical activity questionnaire (GPAQ): nine country reliability and validity study
.
J Phys Act Health
.
2009
;
6
(
6
):
790
804
.
21.
General Assembly of the World Medical Association
.
World Medical Association Declaration of Helsinki: ethical principles for medical research involving human subjects
.
J Am Coll Dent
.
2014
;
81
(
3
):
14
8
.
22.
Abe
T
,
Thiebaud
RS
,
Loenneke
JP
.
DXA-derived lean mass includes the fat-free component of adipose tissue: impact on training-induced changes in body composition
.
J Clin Densitom
.
2018
;
21
(
4
):
595
6
. .
23.
Abe
T
,
Dankel
SJ
,
Loenneke
JP
.
Body fat loss automatically reduces lean mass by changing the fat-free component of adipose tissue
.
Obesity
.
2019
;
27
(
3
):
357
8
. .
24.
Monsalve Álvarez
JM
,
González Zapata
LI
.
[Development of questionnaire to assess food intake in the University of Antioquia, Colombia]
.
Nutr Hosp
.
2011
;
26
(
6
):
1333
44
.
25.
Cohen
J
.
Statistical power analysis for the behavioral sciences
. 2nd ed.
New York, NY
:
Routledge Academic
;
1998
.
26.
IBM Corp
.
IBM SPSS statistics for windows, version 25.0
.
Armonk, NY
:
IBM Corp
;
2017
.
27.
Ho
J
,
Tumkaya
T
,
Aryal
S
,
Choi
H
,
Claridge-Chang
A
.
Moving beyond P values: data analysis with estimation graphics
.
Nat Methods
.
2019
;
16
:
565
6
. .
28.
Boutcher
SH
.
High-intensity intermittent exercise and fat loss
.
J Obes
.
2011
;
2011
:
868305
. .
29.
World Health Organization
.
WHO guidelines on physical activity and sedentary behaviour
.
Geneva, Switzerland
:
World Health Organization
;
2020
.
30.
Malatesta
D
,
Werlen
C
,
Bulfaro
S
,
Chenevière
X
,
Borrani
F
.
Effect of high-intensity interval exercise on lipid oxidation during postexercise recovery
.
Med Sci Sports Exerc
.
2009
;
41
(
2
):
364
74
. .
31.
Srikanthan
P
,
Karlamangla
AS
.
Relative muscle mass is inversely associated with insulin resistance and prediabetes. Findings from the third National Health and Nutrition Examination Survey
.
J Clin Endocrinol Metab
.
2011
;
96
(
9
):
2898
903
. .
32.
Narvaez-Sanchez
R
,
Calderón
JC
,
Vega
G
,
Trillos
MC
,
Ospina
S
.
Skeletal muscle as a protagonist in the pregnancy metabolic syndrome
.
Med Hypotheses
.
2019
;
126
:
26
37
. .
33.
Kim
YH
,
So
WY
.
A low arm and leg muscle mass to total body weight ratio is associated with an increased prevalence of metabolic syndrome: the Korea National Health and Nutrition Examination Survey 2010–2011
.
Technol Health Care
.
2016
;
24
:
655
63
. .
34.
Olsen
DB
,
Sacchetti
M
,
Dela
F
,
Ploug
T
,
Saltin
B
.
Glucose clearance is higher in arm than leg muscle in type 2 diabetes
.
J Physiol
.
2005
;
565
(
2
):
555
62
. .
35.
Robinson
E
,
Durrer
C
,
Simtchouk
S
,
Jung
ME
,
Bourne
JE
,
Voth
E
,
Short-term high-intensity interval and moderate-intensity continuous training reduce leukocyte TLR4 in inactive adults at elevated risk of type 2 diabetes
.
J Appl Physiol
.
2015
;
119
(
5
):
508
16
. .
36.
Little
JP
,
Gillen
JB
,
Percival
ME
,
Safdar
A
,
Tarnopolsky
MA
,
Punthakee
Z
,
Low-volume high-intensity interval training reduces hyperglycemia and increases muscle mitochondrial capacity in patients with type 2 diabetes
.
J Appl Physiol
.
2011
;
111
(
6
):
1554
60
. .
37.
Gibala
MJ
,
Little
JP
,
MacDonald
MJ
,
Hawley
JA
.
Physiological adaptations to low-volume, high-intensity interval training in health and disease
.
J Physiol
.
2012
;
590
(
5
):
1077
84
. .
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