Growth from conception through age 2 years, the “First 1,000 days,” is important for long-term health of the growing fetus and child and is influenced by several factors including breastfeeding and complementary feeding. Low- and middle-income countries face a complicated array of factors that influence healthy growth, ranging from high food insecurity, poor sanitation, limited prenatal or neonatal care, and high levels of poverty that exacerbate the “vicious cycle” associated with intergenerational promotion of growth retardation. It is now well recognized that the period prior to conception, both maternal and paternal health and diet, play an important role in fetal development, giving rise to the concept of the “First 1,000 Days+”. Breastfeeding and complementary feeding practices can be improved through a combination of interventions such as baby-friendly hospitals, regulations for marketing of foods and beverages to children, adequate counseling and support, and sound social and behavior change communication, but continued research is warranted to make such programs more universal and fully effective. Thus, improving the overall understanding of factors that influence growth, such as improved breastfeeding and age-appropriate and adequate complementary feeding, is critical to reducing the global prevalence of the double burden of malnutrition.

1.
Cropley JE, Eaton SA, Aiken A, Young PE, Giannoulatou E, Ho JW, et al. Male-lineage transmission of an acquired metabolic phenotype induced by grand-paternal obesity. Mol Metab. 2016 Jun;5(8):699–708.
2.
Sanchez-Garrido MA, Ruiz-Pino F, Velasco I, Barroso A, Fernandois D, Heras V, et al. Intergenerational Influence of Paternal Obesity on Metabolic and Reproductive Health Parameters of the Offspring: Male-Preferential Impact and Involvement of Kiss1-Mediated Pathways. Endocrinology. 2018 Feb;159(2):1005–18.
3.
Toro-Ramos T, Sichieri R, Hoffman DJ. Maternal fat mass at mid-pregnancy and birth weight in Brazilian women. Ann Hum Biol. 2016 May;43(3):212–8.
4.
Tobi EW, Goeman JJ, Monajemi R, Gu H, Putter H, Zhang Y, et al. DNA methylation signatures link prenatal famine exposure to growth and metabolism. Nat Commun. 2014 Nov;5(1):5592.
5.
Stephenson J, Heslehurst N, Hall J, Schoenaker DAJM, Hutchinson J, Cade JE, et al. Before the beginning: nutrition and lifestyle in the preconception period and its importance for future health. Lancet. 2018 May;391(10132):1830–41.
6.
Perez-Escamilla R, Bermudez O, Buccini GS, Kumanyika S, Lutter CK, Monsivais P, et al. Nutrition disparities and the global burden of malnutrition. BMJ. 2018 Jun;361:k2252.
7.
Rollins NC, Bhandari N, Hajeebhoy N, Horton S, Lutter CK, Martines JC, et al.; Lancet Breastfeeding Series Group. Why invest, and what it will take to improve breastfeeding practices? Lancet. 2016 Jan;387(10017):491–504.
8.
Victora CG, Bahl R, Barros AJ, França GV, Horton S, Krasevec J, et al.; Lancet Breastfeeding Series Group. Breastfeeding in the 21st century: epidemiology, mechanisms, and lifelong effect. Lancet. 2016 Jan;387(10017):475–90.
9.
UNICEF. IYCF database [Internet]. Infant and Young Child Feeding. 2018. Available from: https://data.unicef.org/topic/nutrition/infant-and-young-child-feeding/#status.
10.
Piwoz EG, Huffman SL. The Impact of Marketing of Breast-Milk Substitutes on WHO-Recommended Breastfeeding Practices. Food Nutr Bull. 2015 Dec;36(4):373–86.
11.
Walters D, Eberwein J, Sullivan L, Shekar M. Reaching the global target for breastfeeding. In: Walters D, Eberwein J, Shekar M, editors. An investment framework for nutrition; Reaching the global targets for stunting, anemia, breastfeeding and wasting. Washington : World Bank Group; 2017.
12.
Rollins NC. Breastfeeding: New knowledge and old failures. [Internet]. Rollins NInternational Symposium on Understanding the Double Burden of Malnutrition for Effective Interventions.; 2018 Dec 10; Vienna, Austria. Available from: https://bit.ly/2FA2bGB.
13.
World Health Organization. Infant and young child feeding: model chapter for textbooks for medical students and allied health professionals. Geneva: World Health Organization; 2009.
14.
Zheng JS, Liu H, Zhao YM, Li J, Chen Y, Zhu S, et al. Complementary feeding and childhood adiposity in preschool-aged children in a large Chinese cohort. J Pediatr. 2015 Feb;166(2):326–31.e2.
15.
Morgen CS, Ängquist L, Baker JL, Andersen AN, Sørensen TI, Michaelsen KF. Breastfeeding and complementary feeding in relation to body mass index and overweight at ages 7 and 11 y: a path analysis within the Danish National Birth Cohort. Am J Clin Nutr. 2018 Mar;107(3):313–22.
16.
Schack-Nielsen L, Sørensen TI, Mortensen EL, Michaelsen KF. Late introduction of complementary feeding, rather than duration of breastfeeding, may protect against adult overweight. Am J Clin Nutr. 2010 Mar;91(3):619–27.
17.
English LK, Obbagy JE, Wong YP, Butte NF, Dewey KG, Fox MK, et al. Timing of introduction of complementary foods and beverages and growth, size, and body composition: a systematic review. Am J Clin Nutr. 2019 Mar;109(Supplement_7):935S–955S.
18.
Bégin F, Aguayo VM. First Foods: Why improving young children’s diets matter. Matern Child Nutr. 2017 Oct;13 Suppl 2:e12528.
19.
Sinha B, Chowdhury R, Sankar MJ, Martines J, Taneja S, Mazumder S, et al. Interventions to improve breastfeeding outcomes: a systematic review and meta-analysis. Acta Paediatr. 2015 Dec;104(467):114–34.
20.
Navarro-Rosenblatt D, Garmendia ML. Maternity Leave and Its Impact on Breastfeeding: A Review of the Literature. Breastfeed Med. 2018 Nov;13(9):589–97.
21.
Pérez-Escamilla R, Martinez JL, Segura-Pérez S. Impact of the Baby-friendly Hospital Initiative on breastfeeding and child health outcomes: a systematic review. Matern Child Nutr. 2016 Jul;12(3):402–17.
22.
WHO. UNICEF. Implementation guidance: protecting, promoting and supporting breastfeeding in facilities providing maternity and newborn services – the revised Baby-friendly Hospital Initiative. Geneva: World Health Organization; 2018.
23.
Arts M, Taqi I, Bégin F. Improving the early initiation of breastfeeding: the WHO-UNICEF Breastfeeding Advocacy Initiative. Breastfeed Med. 2017 Jul/Aug;12(6):326–7.
24.
Bégin F, Lapping K, Clark D, Taqi I, Rudert C, Mathisen R, et al. Real-time evaluation can inform global and regional efforts to improve breastfeeding policies and programmes. Matern Child Nutr. 2019 Feb;15 Suppl 2:e12774.
25.
Untoro J, Childs R, Bose I, Winichagoon P, Rudert C, Hall A, et al. Tools to improve planning, implementation, monitoring, and evaluation of complementary feeding programmes. Matern Child Nutr. 2017 Oct;13 Suppl 2:e12438.
26.
Chopra M, Sharkey A, Dalmiya N, Anthony D, Binkin N.; UNICEF Equity in Child Survival, Health and Nutrition Analysis Team. Strategies to improve health coverage and narrow the equity gap in child survival, health, and nutrition. Lancet. 2012 Oct;380(9850):1331–40.
Open Access License / Drug Dosage / Disclaimer
Open Access License: This is an Open Access article licensed under the terms of the Creative Commons Attribution 3.0 IGO License (CC BY 3.0 IGO). Usage, distribution and reproduction in any medium or format, even for commercial purposes, is permitted, provided the original work is properly cited.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.