Background: Postprandial metabolic impairments in diabetes have been shown to play an important role in vascular complications. Dietary polyphenols and other bioactive compounds in berries have been shown to improve postprandial hyperglycemia and related metabolic impairments, but few clinical studies have been reported in diabetes. Objective: To examine the effects of daily dietary raspberries on postprandial and 4-week fasting glucose, lipids and biomarkers of inflammation in obese adults with type 2 diabetes. Design: This was a randomized crossover study with 2 different phases: a “postprandial phase” of acute raspberry supplementation (2 separate days at least 1 week apart), followed by a 1-week washout phase and then a 10-week “diet supplement phase”, with and without raspberry supplementation periods of 4 weeks each, separated by 2-week washout phase. Results: The postprandial phase revealed significantly lower levels of serum glucose at 2 and 4 h postprandial after raspberry versus control phase. In addition, among the serum biomarkers of inflammation, interleukin (IL)-6 and high-sensitivity tumor necrosis factor alpha (hsTNF-α) were also lower at 4 h postprandial following raspberry versus control meal (all p < 0.05). Finally, postprandial serum triglycerides showed a decreasing trend at 4 h in the raspberry versus control phase. Four-week daily raspberry supplementation continued to show a significant lowering effects on IL-6 and hsTNF-α versus control phase (all p < 0.05); systolic blood pressure revealed a decreasing trend after 4-week of raspberry supplementation. No effects were noted on fasting glucose and lipids, C-reactive protein and arterial elasticity. Conclusions: Thus, dietary raspberries, which are low in calories and high in polyphenols and other nutrients may lower postprandial hyperglycemia and inflammation, and in general exert selected anti-inflammatory effects in adults with diabetes. These findings deserve further investigation.

Cassidy A, Bertoia M, Chiuve S, Flint A, Forman J, Rimm EB: Habitual intake of anthocyanins and flavanones and risk of cardiovascular disease in men. Am J Clin Nutr 2016; 104: 587–594.
Jacques PF, Cassidy A, Rogers G, Peterson JJ, Meigs JB, Dwyer JT: Higher dietary flavonol intake is associated with lower incidence of type 2 diabetes. J Nutr 2013; 143: 1474–1480.
Cassidy A, Rogers G, Peterson JJ, Dwyer JT, Lin H, Jacques PF: Higher dietary anthocyanin and flavonol intakes are associated with anti-inflammatory effects in a population of US adults. Am J Clin Nutr 2015; 102: 172–181.
Cavalot F, Pagliarino A, Valle M, Di Martino L, Bonomo K, Massucco P, Anfossi G, Trovati M: Postprandial blood glucose predicts cardiovascular events and all-cause mortality in type 2 diabetes in a 14-year follow-up: lessons from the San Luigi Gonzaga Diabetes Study. Diabetes Care 2011; 34: 2237–2243.
Aslam M, Aggarwal S, Sharma KK, Galav V, Madhu SV: Postprandial hypertriglyceridemia predicts development of insulin resistance glucose intolerance and type 2 diabetes. PLoS One 2016; 11:e0145730.
Dror E, Dalmas E, Meier DT, Wueest S, Thévenet J, Thienel C, Timper K, Nordmann TM, Traub S, Schulze F, Item F, Vallois D, Pattou F, Kerr-Conte J, Lavallard V, Berney T, Thorens B, Konrad D, Böni-Schnetzler M, Donath MY: Postprandial macrophage-derived IL-1β stimulates insulin, and both synergistically promote glucose disposal and inflammation. Nat Immunol 2017; 18: 283–292.
Onat A, Can G, Çiçek G, Ayhan E, Doğan Y, Kaya H: Fasting, non-fasting glucose and HDL dysfunction in risk of pre-diabetes, diabetes, and coronary disease in non-diabetic adults. Acta Diabetol 2013; 50: 519–528.
Leon-Acuña A, Alcala-Diaz JF, Delgado-Lista J, Torres-Peña JD, Lopez-Moreno J, Camargo A, Garcia-Rios A, Marin C, Gomez-Delgado F, Caballero J, Van-Ommen B, Malagon MM, Perez-Martinez P, Lopez-Miranda J: Hepatic insulin resistance both in prediabetic and diabetic patients determines postprandial lipoprotein metabolism: from the CORDIOPREV study. Cardiovasc Diabetol 2016; 15: 68.
Christiansen E, Schnider S, Palmvig B, Tauber-Lassen E, Pedersen O: Intake of a diet high in trans monounsaturated fatty acids or saturated fatty acids. Effects on postprandial insulinemia and glycemia in obese patients with NIDDM. Diabetes Care 1997; 20: 881–887.
Dandona P, Ghanim H, Abuaysheh S, Green K, Batra M, Dhindsa S, Makdissi A, Patel R, Chaudhuri A: Decreased insulin secretion and incretin concentrations and increased glucagon concentrations after a high-fat meal when compared with a high-fruit and -fiber meal. Am J Physiol Endocrinol Metab 2015; 308:E185–E191.
Silva FM, Kramer CK, Crispim D, Azevedo MJ: A high-glycemic index, low-fiber breakfast affects the postprandial plasma glucose, insulin, and ghrelin responses of patients with type 2 diabetes in a randomized clinical trial. J Nutr 2015; 145: 736–741.
Peluso I, Villano DV, Roberts SA, Cesqui E, Raguzzini A, Borges G, Crozier A, Catasta G, Toti E, Serafini M: Consumption of mixed fruit-juice drink and vitamin C reduces postprandial stress induced by a high fat meal in healthy overweight subjects. Curr Pharm Des 2014; 20: 1020–1024.
Burton-Freeman B: Postprandial metabolic events and fruit-derived phenolics: a review of the science. Br J Nutr 2010; 104(suppl 3):S1–S14.
Burton-Freeman B, Linares A, Hyson D, Kappagoda T: Strawberry modulates LDL oxidation and postprandial lipemia in response to high-fat meal in overweight hyperlipidemic men and women. J Am Coll Nutr 2010; 29: 46–54.
Wilson T, Meyers SL, Singh AP, Limburg PJ, Vorsa N: Favorable glycemic response of type 2 diabetics to low-calorie cranberry juice. J Food Sci 2008; 73:H241–H245.
Ono-Moore KD, Snodgrass RG, Huang S, Singh S, Freytag TL, Burnett DJ, Bonnel EL, Woodhouse LR, Zunino SJ, Peerson JM, Lee JY, Rutledge JC, Hwang DH: Postprandial inflammatory responses and free fatty acids in plasma of adults who consumed a moderately high-fat breakfast with and without blueberry powder in a randomized placebo-controlled trial. J Nutr 2016; 146: 1411–1419.
Schell J, Betts NM, Foster M, Scofield RH, Basu A: Cranberries improve postprandial glucose excursions in type 2 diabetes. Food Funct 2017; 8: 3083–3090.
Burton-Freeman BM, Sandhu AK, Edirisinghe I: Red raspberries and their bioactive polyphenols: cardiometabolic and neuronal health links. Adv Nutr 2016; 7: 44–65.
Marathe PH, Gao HX, Close KL: American diabetes association standards of medical care in diabetes 2017. J Diabetes 2017; 9: 320–324.
Törrönen R, Kolehmainen M, Sarkkinen E, Poutanen K, Mykkänen H, Niskanen L: Berries reduce postprandial insulin responses to wheat and rye breads in healthy women. J Nutr 2013; 143: 430–436.
Edirisinghe I, Banaszewski K, Cappozzo J, Sandhya K, Ellis CL, Tadapaneni R, Kappagoda CT, Burton-Freeman BM: Strawberry anthocyanin and its association with postprandial inflammation and insulin. Br J Nutr 2011; 106: 913–922.
Rasouli H, Hosseini-Ghazvini SM, Adibi H, Khodarahmi R: Differential α-amylase/ α-glucosidase inhibitory activities of plant-derived phenolic compounds: a virtual screening perspective for the treatment of obesity and diabetes. Food Funct 2017; 8: 1942–1954.
Bellesia A, Verzelloni E, Tagliazucchi D: Pomegranate ellagitannins inhibit α-glucosidase activity in vitro and reduce starch digestibility under simulated gastro-intestinal conditions. Int J Food Sci Nutr 2015; 66: 85–92.
Hidalgo J, Teuber S, Morera FJ, Ojeda C, Flores CA, Hidalgo MA, Núñez L, Villalobos C, Burgos RA: Delphinidin Reduces Glucose Uptake in Mice Jejunal Tissue and Human Intestinal Cells Lines through FFA1/GPR40. Int J Mol Sci 2017; 18: pii: E750.
Shi C, Men L, Yu C, Yao J, Bai R, Yang Y, Sun L, Sun G, Song G, Zhang Y, Xing Q, Du J: Atherosclerosis associated with dynamic inflammation changes after multifactorial intervention in short-duration type 2 diabetes: a randomized, controlled, 10-year follow-up trial. J Diabetes Complications 2017; 31: 1286–1292.
Joseph SV, Edirisinghe I, Burton-Freeman BM: Fruit polyphenols: a review of anti-inflammatory effects in humans. Crit Rev Food Sci Nutr 2016; 56: 419–444.
Sangiovanni E, Vrhovsek U, Rossoni G, Colombo E, Brunelli C, Brembati L, Trivulzio S, Gasperotti M, Mattivi F, Bosisio E, Dell’Agli M: Ellagitannins from Rubus berries for the control of gastric inflammation: in vitro and in vivo studies. PLoS One 2013; 8:e71762.
Li L, Wang L, Wu Z, Yao L, Wu Y, Huang L, Liu K, Zhou X, Gou D: Anthocyanin-rich fractions from red raspberries attenuate inflammation in both RAW264.7 macrophages and a mouse model of colitis. Sci Rep 2014; 4: 6234.
Koloverou E, Panagiotakos DB, Georgousopoulou EN, Chrysohoou C, Tousoulis D, Stefanadis C, Pitsavos C; ATTICA Study Group: Single and combined effects of inflammatory markers on 10 year diabetes incidence: the mediating role of adiposity-Results from the ATTICA cohort study. Diabetes Metab Res Rev 2017; 34.
Klüppelholz B, Thorand B, Koenig W, de Las Heras Gala T, Meisinger C, Huth C, Giani G, Franks PW, Roden M, Rathmann W, Peters A, Herder C: Association of subclinical inflammation with deterioration of glycaemia before the diagnosis of type 2 diabetes: the KORA S4/F4 study. Diabetologia 2015; 58: 2269–2277.
Emerson SR, Kurti SP, Harms CA, Haub MD, Melgarejo T, Logan C, Rosenkranz SK: Magnitude and timing of the postprandial inflammatory response to a high-fat meal in healthy adults: a systematic review. Adv Nutr 2017; 8: 213–225.
An JH, Kim DL, Lee TB, Kim KJ, Kim SH, Kim NH, Kim HY, Choi DS, Kim SG: Effect of rubus occidentalis extract on metabolic parameters in subjects with prediabetes: a proof-of-concept, randomized, double-blind, placebo-controlled clinical trial. Phytother Res 2016; 30: 1634–1640.
Jeong HS, Hong SJ, Lee TB, Kwon JW, Jeong JT, Joo HJ, Park JH, Ahn CM, Yu CW, Lim DS: Effects of black raspberry on lipid profiles and vascular endothelial function in patients with metabolic syndrome. Phytother Res 2014; 28: 1492–1498.
Jeong HS, Hong SJ, Cho JY, Lee TB, Kwon JW, Joo HJ, Park JH, Yu CW, Lim DS: Effects of rubus occidentalis extract on blood pressure in patients with prehypertension: Randomized, double-blinded, placebo-controlled clinical trial. Nutrition 2016; 32: 461–467.
Jennings A, Welch AA, Fairweather-Tait SJ, Kay C, Minihane AM, Chowienczyk P, Jiang B, Cecelja M, Spector T, Macgregor A, Cassidy A: Higher anthocyanin intake is associated with lower arterial stiffness and central blood pressure in women. Am J Clin Nutr 2012; 96: 781–788.
Cassidy A, O’Reilly ÉJ, Kay C, Sampson L, Franz M, Forman JP, Curhan G, Rimm EB: Habitual intake of flavonoid subclasses and incident hypertension in adults. Am J Clin Nutr 2011; 93: 338–347.
Min J, Jahns L, Xue H, Kandiah J, Wang Y: Americans’ perceptions about fast food and how they associate with its consumption and obesity risk. Adv Nutr 2018; 5: 590–601.
Braithwaite I, Stewart AW, Hancox RJ, Beasley R, Murphy R, Mitchell EA; ISAAC Phase Three Study Group; ISAAC Phase Three Study Group: Fast-food consumption and body mass index in children and adolescents: an international cross-sectional study. BMJ Open 2014; 4:e005813.
Devaraj S, Wang-Polagruto J, Polagruto J, Keen CL, Jialal I: High-fat, energy-dense, fast-food-style breakfast results in an increase in oxidative stress in metabolic syndrome. Metabolism 2008; 57: 867–870.
Ursini F, Zamburlini A, Cazzolato G, Maiorino M, Bon GB, Sevanian A: Postprandial plasma lipid hydroperoxides: a possible link between diet and atherosclerosis. Free Radic Biol Med 1998; 25: 250–252.
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