Research on vitamins has advanced considerably over the past 100 years with numerous advancements in the fields of biochemistry, medicine, and nutrition. The purpose of this article is to present the history of vitamins using Nobel Prizes as a framework for each vitamin-related discovery. The Nobel Prize Presentation Speech and Nobel Lecture were reviewed for each Nobel Laureate who received an award for vitamin-related research. The original scientific work of a number of awardees was also utilized as a primary source of the history. Nobel Prizes were awarded primarily for the identification, isolation, and synthesis of vitamins. Additional awards recognized the role of specific vitamins in disease processes. The awarding of over 10 Nobel Prizes in Chemistry, Physiology or Medicine in the last century has recognized the seminal work of numerous scientists and physicians and showcased multiple important advancements in vitamins research.

1.
Lind J: A Treatise on the Scurvy. London, A Millar, 1753.
2.
Carpenter KC: The History of Scurvy and Vitamin C. Cambridge, Cambridge University Press, 1988.
3.
Nobelstiftelsen: Les Prix Nobel en 1929. Stockholm, Imprimerie Royale, P.A. Norstedt & Söner, 1930.
4.
Schneider D, Lilienfeld DE (eds): Public Health: The Development of a Discipline, Twentieth-Century Challenges, vol 2. New Jersey, Rutgers, The State University, 2001.
5.
Rosenfeld L: Vitamine – vitamin. The early years of discovery. Clin Chem 1997;43:680–685.
6.
Griminger P: Casimir Funk – a biographical sketch (1884–1967). J Nutr 1972;102:110–114.
7.
Nobelstiftelsen: Les Prix Nobel en 1934. Stockholm, Imprimerie Royale, P.A. Norstedt & Söner, 1935.
8.
Robscheit-Robbins FS, Whipple GH: Blood regeneration in severe anemia. J Exp Med 1929;49:215–227.
9.
Minot GR, Murphy MP: Treatment of pernicious anemia by a special diet. JAMA 1926;87:470–476.
10.
Sullivan LW, Herbert V, Castle WB: In vitro assay for human intrinsic factor. J Clin Investig 1963;42:1443–1458.
11.
Cannon JR, Johnson AW, Todd AR: Structure of vitamin B12; a crystalline nucleotide-free degradation product of vitamin B12. Nature 1954;174:1168–1169.
12.
Hodgkin DR, Pickworth J, Robertson JH, Trueblood KN, Prosen RJ, White JG: The crystal structure of the hexacarboxylic acid derived from B12 and the molecular structure of the vitamin. Nature 1955;176:325–328.
13.
Nobelstiftelsen: Les Prix Nobel en 1964. Stockholm, Imprimerie Royale, P.A. Norstedt & Söner, 1965.
14.
Nobelstiftelsen: Les Prix Nobel en 1957. Stockholm, Imprimerie Royale, P.A. Norstedt & Söner, 1958.
15.
Woodward B: The total synthesis of vitamin B12. Pure Appl Chem 1873;33:145–178.
16.
Nobelstiftelsen: Les Prix Nobel en 1965. Stockholm, Imprimerie Royale, P.A. Norstedt & Söner, 1966.
17.
Patton AR: Nutrient pioneers: Elmer McCollum. J Orthomol Psych 1984;13:269–271.
18.
Bollet AJ: Politics and pellagra: the epidemic of pellagra in the US in the early twentieth century. Yale J Biol Med 1992;65:211–221.
19.
Goldberger JG, Wheeler GA, Lillie RD, Rogers LM: A further study of butter, fresh beef and yeast as pellagra preventives, with consideration of factor P-P of pellagra (and black tongue of dogs) to vitamin B1. Public Health Rep 1926;41:297–318.
20.
Elvehjem CA, Madden RJ, Strong FM, Wolley DW: The isolation and identification of the anti-black tongue factor. J Biol Chem 1937;277:137–149.
21.
Nobelstiftelsen: Les Prix Nobel en 1938. Stockholm, Imprimerie Royale, P.A. Norstedt & Söner, 1939.
22.
Nobelstiftelsen: Les Prix Nobel en 1937. Stockholm, Imprimerie Royale, P.A. Norstedt & Söner, 1938.
23.
Nobelstiftelsen: Les Prix Nobel en 1942. Stockholm, Imprimerie Royale, P.A. Norstedt & Söner, 1943.
24.
Nobelstiftelsen. Les Prix Nobel en 1928. Stockholm, Imprimerie Royale, P.A. Norstedt & Söner, 1929.
25.
Wolf G: The discovery of vitamin D: the contribution of Adolf Windaus. J Nutr 2004;134:1299–1302.
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.