The relative contribution of nutrition-related chronic diseases to the total disease burden of the society and the health care costs has risen continuously over the last decades. Thus, there is an urgent necessity to better exploit the potential of dietary prevention of diseases. Carbohydrates play a major role in human nutrition – next to fat, carbohydrates are the second biggest group of energy-yielding nutrients. Obesity, type 2 diabetes mellitus, dyslipoproteinaemia, hypertension, metabolic syndrome, coronary heart disease and cancer are wide-spread diseases, in which carbohydrates could have a pathophysiologic relevance. Correspondingly, modification of carbohydrate intake could have a preventive potential. In the present evidence-based guideline of the German Nutrition Society, the potential role of carbohydrates in the primary prevention of the named diseases was judged systematically. The major findings were: a high carbohydrate intake at the expense of total fat and saturated fatty acids reduces the concentrations of total, LDL and HDL cholesterol. A high carbohydrate consumption at the expense of polyunsaturated fatty acids increases total and LDL cholesterol, but reduces HDL cholesterol. Regardless of the type of fat being replaced, a high carbohydrate intake promotes an increase in the triglyceride concentration. Furthermore, a high consumption of sugar-sweetened beverages increases the risk of obesity and type 2 diabetes mellitus, whereas a high dietary fibre intake, mainly from whole-grain products, reduces the risk of obesity, type 2 diabetes mellitus, dyslipoproteinaemia, cardiovascular disease and colorectal cancer at varying evidence levels. The practical consequences for current dietary recommendations are presented.

Keywords:
Dyslipoproteinaemia, Cancer, Prevention, Carbohydrates, Obesity, Type 2 diabetes, Coronary heart disease, Hypertension, Metabolic syndrome
1.
Adams T, Rini A: Predicting 1-year change in body mass index among college students. J Am Coll Health 2007;55:361–365.
2.
Albala C, Ebbeling CB, Cifuentes M, et al: Effects of replacing the habitual consumption of sugar-sweetened beverages with milk in Chilean children. Am J Clin Nutr 2008;88:605–611.
3.
Alberti KG, Zimmet P, Shaw J, IDF Epidemiology Task Force Consensus Group: The metabolic syndrome – a new worldwide definition. Lancet 2005;366:1059–1062.
4.
Aller R, de Luis DA, Izaola O, et al: Effect of soluble fiber intake in lipid and glucose levels in healthy subjects: a randomized clinical trial. Diabetes Res Clin Pract 2004;65:7–11.
5.
Alonso A, Beunza JJ, Bes-Rastrollo M, et al: Vegetable protein and fiber from cereal are inversely associated with the risk of hypertension in a Spanish cohort. Arch Med Res 2006;37:778–786.
6.
Anderson JW: Whole-grains intake and risk for coronary heart disease; in Marquart L, Slavin JL, Fulcher G (eds): Whole grain foods in health and disease. St Paul, Minn: American Association of Cereal Chemists, 2005, pp 187–200.
7.
Anderson JW, Garrity TF, Wood CL, et al: Prospective, randomized, controlled comparison of the effects of low-fat and low-fat plus high-fiber diets on serum lipid concentrations. Am J Clin Nutr 1992;56:887–894.
8.
Archer SL, Liu K, Dyer AR, et al: Relationship between changes in dietary sucrose and high density lipoprotein cholesterol: the CARDIA study. Coronary Artery Risk Development in Young Adults. Ann Epidemiol 1998;8:433–438.
9.
Ascherio A, Hennekens C, Willett WC, et al: Prospective study of nutritional factors, blood pressure, and hypertension among US women. Hypertension 1996;27:1065–1072.
10.
Ascherio A, Rimm EB, Giovannucci EL, et al: A prospective study of nutritional factors and hypertension among US men. Circulation 1992;86:1475–1484.
11.
Aston LM, Stokes CS, Jebb SA: No effect of a diet with a reduced glycaemic index on satiety, energy intake and body weight in overweight and obese women. Int J Obes (Lond) 2008;32:160–165.
12.
Barclay AW, Petocz P, McMillan-Price J, et al: Glycemic index, glycemic load, and chronic disease risk – a meta-analysis of observational studies. Am J Clin Nutr 2008;87:627–637.
13.
Barclay AW, Flood VM, Rochtchina E, et al: Glycemic index, dietary fiber, and risk of type 2 diabetes in a cohort of older Australians. Diabetes Care 2007;30:2811–2813.
14.
Bazzano LA, Song Y, Bubes V, et al: Dietary intake of whole and refined grain breakfast cereals and weight gain in men. Obes Res 2005;13:1952–1960.
15.
Bazzano LA, He J, Ogden LG, et al: National Health and Nutrition Examination Survey I Epidemiologic Follow-up Study. Dietary fiber intake and reduced risk of coronary heart disease in US men and women: the National Health and Nutrition Examination Survey I Epidemiologic Follow-up Study. Arch Intern Med 2003;163:1897–1904.
16.
Berkey CS, Rockett HR, Field AE, et al: Sugar-added beverages and adolescent weight change. Obes Res 2004;12:778–788.
17.
Berkey CS, Rockett HR, Field AE, et al: Activity, dietary intake, and weight changes in a longitudinal study of preadolescent and adolescent boys and girls. Pediatrics 2000;105:E56.
18.
Bes-Rastrollo M, Sanchez-Villegas A, Gomez-Gracia E, et al: Predictors of weight gain in a Mediterranean cohort: the Seguimiento Universidad de Navarra Study 1. Am J Clin Nutr 2006;83:362–370.
19.
Beulens JWJ, de Bruijne LM, Stolk RP, et al: High dietary glycemic load and glycemic index increase risk of cardiovascular disease among middle-aged women. A population-based follow-up study. J Am Coll Cardiol 2007;50:14–21.
20.
Bingham SA, Norat T, Moskal A, et al: Is the association with fiber from foods in colorectal cancer confounded by folate intake? Cancer Epidemiol Biomarkers Prev 2005;14:1552–1556.
21.
Blum JW, Jacobsen DJ, Donnelly JE: Beverage consumption patterns in elementary school aged children across a two-year period. J Am Coll Nutr 2005;24:93–98.
22.
Bogaert N, Steinbeck KS, Baur LA, et al: Food, activity and family – environmental versus biochemical predictors of weight gain in children. Eur J Clin Nutr 2003;57:1242–1249.
23.
Boreham C, Twisk J, van Mechelen W, et al: Relationships between the development of biological risk factors for coronary heart disease and lifestyle parameters during adolescence: The Northern Ireland Young Hearts Project. Public Health 1999;113:7–12.
24.
Bouché C, Rizkalla SW, Luo J, et al: Five-week, low-glycemic index diet decreases total fat mass and improves plasma lipid profile in moderately overweight nondiabetic men. Diabetes Care 2002;25:822–828.
25.
Boyd NF, Cousins M, Beaton M, et al: Quantitative changes in dietary fat intake and serum cholesterol in women: results from a randomized, controlled trial. Am J Clin Nutr 1990;52:470–476.
26.
Brown L, Rosner B, Willett WW, Sacks FM: Cholesterol-lowering effects of dietary fiber: a meta-analysis. Am J Clin Nutr 1999;69:30–42.
27.
Brown RC, Cox CM: Effects of high fat versus high carbohydrate diets on plasma lipids and lipoproteins in endurance athletes. Med Sci Sports Exerc 1998;30:1677–1683.
28.
Buyken AE, Cheng G, Gunther AL, et al: Relation of dietary glycemic index, glycemic load, added sugar intake, or fiber intake to the development of body composition between ages 2 and 7 y. Am J Clin Nutr 2008;88:755–762.
29.
Cade JE, Burley VJ, Greenwood DC; UK Women’s Cohort Study Steering Group: Dietary fibre and risk of breast cancer in the UK Women’s Cohort Study. Int J Epidemiol 2007;36:431–438.
30.
Cao Y, Maugre DT, Pelkman CL, et al: Effects of moderate (MF) versus lower fat (LF) diets on lipids and lipoproteins: a meta-analysis of clinical trials in subjects with and without diabetes. J Lipidol 2009;3:19–32.
31.
Carnethon MR, Sidney S, Loria CM, et al: Risk factors for the metabolic syndrome. The Coronary Artery Risk Development in Young Adults (CARDIA) study, 1985–2001. Diabetes Care 2004;27:2707–2715.
32.
Chen L, Appel LJ, Loria C, et al: Reduction in consumption of sugar-sweetened beverages is associated with weight loss: the PREMIER trial. Am J Clin Nutr 2009;89:1299–1306.
33.
Chen J, He J, Wildman RP, et al: A randomized controlled trial of dietary fiber intake on serum lipids. Eur J Clin Nutr 2006;60:62–68.
34.
Cheng G, Karaolis-Danckert N, Libuda L, et al: Relation of dietary glycemic index, glycemic load, and fiber and whole-grain intakes during puberty to the concurrent development of percent body fat and body mass index. Am J Epidemiol 2009;169:667–677.
35.
Clarke R, Frost C, Collins R, Appleby P, Peto R: Dietary lipids and blood cholesterol: quantitative meta-analysis of metabolic ward studies. BMJ 1997;314:112–117.
36.
Colditz GA, Manson JE, Stampfer MJ, et al: Diet and risk of clinical diabetes in women. Am J Clin Nutr 1992;55:1018–1023.
37.
Colditz GA, Willett WC, Stampfer MJ, et al: Patterns of weight change and their relation to diet in a cohort of healthy women. Am J Clin Nutr 1990;5:1100–1105.
38.
Connor SL, Gustafson JR, Sexton G, et al: The Diet Habit Survey: a new method of dietary assessment that relates to plasma cholesterol changes. J Am Diet Assoc 1992;92:41–47.
39.
Cust AE, Slimani N, Kaaks R, et al: Dietary carbohydrates, glycemic index, glycemic load, and endometrial cancer risk within the European Prospective Investigation into Cancer and Nutrition cohort. Am J Epidemiol 2007;166:912–923.
40.
Damiao R, Castro TG, Cardoso MA, et al: Dietary intakes associated with the metabolic syndrome in a cohort of Japanese ancestry. Br J Nutr 2006;96:532–538.
41.
Davis JN, Alexander KE, Ventura EE, et al: Inverse relation between dietary fiber intake and visceral adiposity in overweight Latino youth. Am J Clin Nutr 2009;90:1160–1166.
42.
Davy BM, Melby CL, Beske SD, et al: Oat consumption does not affect resting casual and ambulatory 24-h arterial blood pressure in men with high-normal blood pressure to stage I hypertension. J Nutr 2002;132:394–398.
43.
de Castro TG, Gimeno SG, Ferreira SR, Cardoso MA; and Group, Japanese-Brazilian Diabetes Study: Association of dietary fiber with temporal changes in serum cholesterol in Japanese-Brazilians. J Nutr Sci Vitaminol 2006;52:205–210.
44.
de Munter JS, Hu FB, Spiegelman D, et al: Whole grain, bran, and germ intake and risk of type 2 diabetes: a prospective cohort study and systematic review. PLoS Med 2007;4:e26.
45.
DGE (Deutsche Gesellschaft für Ernährung, ed): Kohlenhydratzufuhr und Prävention ausgewählter ernährungsmitbedingter Krankheiten – Evidenzbasierte Leitlinie. Bonn 2011a. http://www.dge.de/leitlinie.
46.
DGE (Deutsche Gesellschaft für Ernährung, ed): DGE-Position: Richtwerte für die Energiezufuhr aus Kohlenhydraten und Fett. Ernaehrungs Umschau 2011b;58:152–154.
47.
DGE (Deutsche Gesellschaft für Ernährung, ed): Vollwertig essen und trinken nach den 10 Regeln der DGE. 7. Auflage, Bonn, 2010.
48.
DGE (Deutsche Gesellschaft für Ernährung, ed): Ernährungsbericht 2008. Bonn, 2008.
49.
DGE (Deutsche Gesellschaft für Ernährung, ed): Stellungnahme ‘Obst und Gemüse in der Prävention chronischer Krankheiten’. Bonn, 2007. http://www.dge.de/pdf/ws/Stellungnahme-OuG-Praevention-chronischerKrankheiten-2007-09-29.pdf (accessed on: September 24, 2010).
50.
DGE (Deutsche Gesellschaft für Ernährung, ed): Fettkonsum und Prävention ausgewählter ernährungsmitbedingter Krankheiten – Evidenzbasierte Leitlinie. Bonn, 2006. http://www.dge.de/leitlinie.
51.
Dhingra R, Sullivan L, Jacques PF, et al: Soft drink consumption and risk of developing cardiometabolic risk factors and the metabolic syndrome in middle-aged adults in the community. Circulation 2007;116:480–488.
52.
DiMeglio DP, Mattes RD: Liquid versus solid carbohydrate: effects on food intake and body weight. Int J Obes Relat Metab Disord 2000;24:794–800.
53.
Du H, van der A DL, Boshuizen HC, et al: Dietary fiber and subsequent changes in body weight and waist circumference in European men and women. Am J Clin Nutr 2010;91:329–336.
54.
Du H, van der A DL, van Bakel MM, et al: Dietary glycaemic index, glycaemic load and subsequent changes of weight and waist circumference in European men and women. Int J Obes (Lond) 2009;33:1280–1288.
55.
Dubois L, Farmer A, Girard M, Peterson K: Regular sugar-sweetened beverage consumption between meals increases risk of overweight among preschol-aged children. J Am Diet Assoc 2007;107:924–934; discussion 934–935.
56.
Eastwood MA, Elton RA, Smith JH: Long-term effect of wholemeal bread on stool weight, transit time, fecal bile acids, fats, and neutral sterols. Am J Clin Nutr 1986;43:343–349.
57.
Ebbeling CB, Feldman HA, Osganian SK, et al: Effects of decreasing sugar-sweetened beverage consumption on body weight in adolescents: a randomized, controlled pilot study. Pediatrics 2006;117:673–680.
58.
Ebbeling CB, Leidig MM, Sinclair KB, et al: Effects of an ad libitum low glycemic load diet on cardiovascular disease risk factors in obese young adults. Am J Clin Nutr 2005;81:976–982.
59.
Eiben G, Lissner L: Health Hunters – an intervention to prevent overweight and obesity in young high-risk women. Int J Obes (Lond) 2006;30:691–696.
60.
Esrey KL, Joseph L, Grover SA: Relationship between dietary intake and coronary heart disease mortality: lipid research clinics prevalence follow-up study. J Clin Epidemiol 1996;49:211–216.
61.
Feskens EJ, Virtanen SM, Rasanen L, et al: Dietary factors determining diabetes and impaired glucose tolerance. A 20-year follow-up of the Finnish and Dutch cohorts of the Seven Countries Study. Diabetes Care 1995;18:1104–1112.
62.
Feskens EJ, Bowles CH, Kromhout D: Carbohydrate intake and body mass index in relation to the risk of glucose intolerance in an elderly population. Am J Clin Nutr 1991;54:136–140.
63.
Fiorito LM, Marini M, Francis LA, et al: Beverage intake of girls at age 5 y predicts adiposity and weight status in childhood and adolescence. Am J Clin Nutr 2009;90:935–942.
64.
Fisher E, Boeing H, Fritsche A, et al: Whole-grain consumption and transcription factor-7-like 2 (TCF7L2) rs7903146: gene-diet interaction in modulating type 2 diabetes risk. Br J Nutr 2009;101:478–481.
65.
Flint AJ, Hu FB, Glynn RJ, et al: Whole grains and incident hypertension in men. Am J Clin Nutr 2009;90:493–498.
66.
Forman JP, Choi H, Curhan GC: Fructose and vitamin C intake do not influence risk for developing hypertension. J Am Soc Nephrol 2009;20:863–871.
67.
Forshee RA, Anderson PA, Storey ML: Sugar-sweetened beverages and body mass index in children and adolescents: a meta-analysis. Am J Clin Nutr 2008;87:1662–1671.
68.
Fung TT, Malik V, Rexrode KM, et al: Sweetened beverage consumption and risk of coronary heart disease in women. Am J Clin Nutr 2009;89:1037–1042.
69.
Fung TT, Hu FB, Pereira MA, et al: Whole-grain intake and the risk of type 2 diabetes: a prospective study in men. Am J Clin Nutr 2002;76:535–540.
70.
Gallus S, Turati F, Tavani A, et al: Soft drinks, sweetened beverages and risk of pancreatic cancer. Cancer Causes Control 2011;22:33–39. Epub 2010 Oct 28.
71.
Garcia-Palmieri MR, Sorlie P, Tillotson J, et al: Relationship of dietary intake to subsequent coronary heart disease incidence: The Puerto Rico Heart Health Program. Am J Clin Nutr 1980;33:1818–1827.
72.
Garry PJ, Hunt WC, Koehler KM, et al: Longitudinal study of dietary intakes and plasma lipids in healthy elderly men and women. Am J Clin Nutr 1992;55:682–688.
73.
Gatenby SJ, Aaron JI, Jack VA, Mela DJ: Extended use of foods modified in fat and sugar content: nutritional implications in a free-living female population. Am J Clin Nutr 1997;65:1867–1873.
74.
George SM, Mayne ST, Leitzmann MF, et al: Dietary glycemic index, glycemic load, and risk of cancer: a prospective cohort study. Am J Epidemiol 2009;169:462–472.
75.
Gibson S: Sugar-sweetened soft drinks and obesity: a systematic review of the evidence from observational studies and interventions. Nutr Res Rev 2008;21:134–147.
76.
Giles GG, Simpson JA, English DR, et al: Dietary carbohydrate, fibre, glycaemic index, glycaemic load and the risk of postmenopausal breast cancer. Int J Cancer 2006;118:1843–1847.
77.
Gnagnarella P, Gandini S, La Vecchia C, Maisonneuve P: Glycemic index, glycemic load, and cancer risk: a meta-analysis. Am J Clin Nutr 2008;87:1793–1801.
78.
Gordon T, Kagan A, Garcia-Palmieri M, et al: Diet and its relation to coronary heart disease and death in three populations. Circulation 1981;63:500–515.
79.
Grandjean AC, Reimers KJ, Bannick KE, Haven MC: The effect of caffeinated, non-caffeinated, caloric and non-caloric beverages on hydration. J Am Coll Nutr 2000;19:591–600.
80.
Halkjaer J, Tjonneland A, Thomsen BL, et al: Intake of macronutrients as predictors of 5-y changes in waist circumference. Am J Clin Nutr 2006;84:789–797.
81.
Halkjaer J, Sorensen TI, Tjonneland A, et al: Food and drinking patterns as predictors of 6-year BMI-adjusted changes in waist circumference. Br J Nutr 2004;92:735–748.
82.
Halton TL, Liu S, Manson JE, Hu FB: Low-carbohydrate-diet score and risk of type 2 diabetes in women. Am J Clin Nutr 2008;87:339–346.
83.
Halton TL, Willett WC, Liu S, et al: Low-carbohydrate-diet score and the risk of coronary heart disease in women. N Engl J Med 2006;355:1991–2002.
84.
Hare-Bruun H, Flint A, Heitmann BL: Glycemic index and glycemic load in relation to changes in body weight, body fat distribution, and body composition in adult Danes. Am J Clin Nutr 2006;84:871–879.
85.
Harding AH, Day NE, Khaw KT, et al: Dietary fat and the risk of clinical type 2 diabetes: the European prospective investigation of Cancer-Norfolk study. Am J Epidemiol 2004;159:73–82.
86.
Haub MD, Simons TR, Cook CM, et al: Calcium-fortified beverage supplementation on body conposition in postmenopausal women. Nutr J 2005;4:21.
87.
Heaton KW, Manning AP, Hartog M: Lack of effect on blood lipid and calcium concentrations of young men on changing from white to wholemeal bread. Br J Nutr 1976;35:55–60.
88.
Heinen MM, Verhage BA, Lumey L, et al: Glycemic load, glycemic index, and pancreatic cancer risk in the Netherlands Cohort Study. Am J Clin Nutr 2008;87:970–977.
89.
Hodge AM, English DR, O’Dea K, Giles GG: Glycemic index and dietary fiber and the risk of type 2 diabetes. Diabetes Care 2004;27:2701–2706.
90.
Hopping BN, Erber E, Grandinetti A, et al: Dietary fiber, magnesium, and glycemic load alter risk of type 2 diabetes in a multiethnic cohort in Hawaii. J Nutr 2010;140:68–74.
91.
Howard BV, Manson JE, Stefanick ML, et al: Low-fat dietary pattern and weight change over 7 years: the Women’s Health Initiative Dietary Modification Trial. JAMA 2006;295:39–49.
92.
Howarth NC, Murphy SP, Wilkens LR, et al: The association of glycemic load and carbohydrate intake with colorectal cancer risk in the Multiethnic Cohort Study. Am J Clin Nutr 2008;88:1074–1082.
93.
Hu FB, Manson JE, Stampfer MJ, et al: Diet, Lifestyle, and the risk of type 2 diabetes mellitus in women. N Engl J Med 2001;345:790–797.
94.
Huttunen JK, Mäkinen KK, Scheinin A: Turku sugar studies XI. Effects of sucrose, fructose and xylitol diets on glucose, Lipid and urate metabolism. Acta Odontol Scand 1976;34:345–351.
95.
International Journal of Obesity: 9th and 10th international symposia organized by the Merck Frosst/CIHR Research Chair in Obesity, Université Laval, Québec, Qué, Canada, Auberge Saint-Antoine, Québec, QC, Canada, 15–16 November 2007. 1. Gastrointestinal Tract, Obesity and Diabetes, 2. Childhood Obesity: Biological/Environmental Determinants and Preventative Strategies 2009;33:S1.
96.
Iqbal Kring N, Heitmann BL: Fiber intake, not dietary energy density, is associated with subsequent change in BMI z-score among sub-groups of children. Obes Facts 2008;1:331–338.
97.
Iqbal SI, Helge JW, Heitmann BL: Do energy density and dietary fiber influence subsequent 5-year weight changes in adult men and women? Obesity (Silver Spring) 2006;14:106–114.
98.
Jakobsen MU, O’Reilly EJ, Heitmann BL, et al: Major types of dietary fat and risk of coronary heart disease: a pooled analysis of 11 cohort studies. Am J Clin Nutr 2009;89:1425–1432.
99.
James J, Thomas P, Kerr D: Preventing childhood obesity: two year follow-up results fron the Christchurch obesity prevention programme in schools (CHOPPS). BMJ 2007;335:762.
100.
James J, Thomas P, Cavan D, Kerr D: Preventing childhood obesity by reducing consumption of carbonated drinks: cluster randomised controlled trial. BMJ 2004;328:1237.
101.
Janket SJ, Manson JE, Sesso H, et al: A prospective study of sugar intake and risk of type 2 diabetes in women. Diabetes Care 2003;26:1008–1015.
102.
Jiao L, Flood A, Subar AF, et al: Glycemic index, carbohydrates, glycemic load, and the risk of pancreatic cancer in a prospective cohort study. Cancer Epidemiol Biomarkers Prev 2009;18:1144–1151.
103.
Johnson L, Mander AP, Jones LR, et al: Is sugar-sweetened beverage consumption associated with increased fatness in children? Nutrition 2007;23:557–563.
104.
Jones JM: Dietary sweeteners containing fructose: overview of a workshop on the state of the science. J Nutr 2009;139:1210S–1213S.
105.
Kabat GC, Shikany JM, Beresford SA, et al: Dietary carbohydrate, glycemic index, and glycemic load in relation to colorectal cancer risk in the Women’s Health Initiative. Cancer Causes Control 2008;19:1291–1298.
106.
Kaitosaari T, Rönnemaa T, Raitakari O, et al: Effect of 7-year infancy-onset dietary intervention on serum lipoproteins and lipoprotein subclasses in healthy children in the prospective, randomized Special Turku Coronary Risk Factor Intervention Project for children (STRIP) Study. Circulation 2003;108:672–677.
107.
Karnehed N, Tynelius P, Heitmann BL, Rasmussen F: Physical activity, diet and gene-environment interactions in relation to body mass index and waist circumference: the Swedish young male twins study. Public Health Nutr 2006;9:851–858.
108.
Kasim SE, Martino S, Kim PN, et al: Dietary and anthropometric determinants of plasma lipoproteins during a long-term low-fat diet in healthy women. Am J Clin Nutr 1993;57:146–153.
109.
Kasim-Karakas SE, Almario RU, Mueller WM, Peerson J: Changes in plasma lipoproteins during low-fat, high-carbohydrate diets: effects of energy intake. Am J Clin Nutr 2000;71:1439–1447.
110.
Kelly SAM, Summerbell CD, Brynes A, et al: Wholegrain cereals for coronary heart disease. Cochrane Database of Systematic Reviews 2007, Issue 2. Art. No: CD005051.
111.
Kelly S, Frost G, Whittaker V, et al: Low glycaemic index diets for coronary heart disease. Cochrane Database of Systematic Reviews 2004, Issue 4. Art. No: CD004467.
112.
Klesges RC, Isbell TR, Klesges LM: Relationship between dietary restraint, energy intake, physical activity, and body weight: a prospective analysis. J Abnorm Psychol 1992;10:668–674.
113.
Knorpp L, Kroke A: Evidenzbasierung von Massnahmen der bevölkerungsbezogenen Prävention von ernährungsassoziierten Erkrankungen. Ernaehrungs Umschau 2011;58:73–79.
114.
Kochar J, Djousse L, Gaziano JM: Breakfast cereals and risk of type 2 diabetes in the Physicians’ Health Study I. Obesity (Silver Spring) 2007;15:3039–3044.
115.
Koh-Banerjee P, Franz M, Sampson L, et al: Changes in whole-grain, bran, and cereal fiber consumption in relation to 8-y weight gain among men. Am J Clin Nutr 2004;80:1237–1245.
116.
Kral TV, Stunkard AJ, Berkowitz RI, et al: Beverage consumption patterns of children born at different risk of obesity. Obesity (Silver Spring) 2008;16:1802–1808.
117.
Krauss RM, Blanche PJ, Rawlings RS, et al: Separate effects of reduced carbohydrate intake and weight loss on atherogenic dyslipidemia. Am J Clin Nutr 2006;83:1025–1031.
118.
Krishnan S, Rosenberg L, Singer M, et al: Glycemic index, glycemic load, and cereal fiber intake and risk of type 2 diabetes in US black women. Arch Intern Med 2007;167:2304–2309.
119.
Kroke A, Boeing H, Rossnagel K, Willich SN: History of the concept of ‘levels of evidence’ and their current status in relation to primary prevention through lifestyle interventions. Public Health Nutr 2003;2:279–284.
120.
Kvaavik E, Andersen LF, Klepp KI: The stability of soft drinks intake from adolescence to adult age and the association between long-term consumption of soft drinks and lifestyle factors and body weight. Public Health Nutr 2005;8:149–157.
121.
Lagiou P, Sandin S, Weiderpass E, et al: Low carbohydrate-high protein diet and mortality in a cohort of Swedish women. J Intern Med 2007;261:366–374.
122.
Lagström H, Seppänen R, Jokinen E, et al: Influence of dietary fat on the nutrient intake and growth of children from 1 to 5 y of age: the Special Turku Coronary Risk Factor Intervention Project. Am J Clin Nutr 1999;69:516–523.
123.
Lajous M, Boutron-Ruault MC, Fabre A, et al: Carbohydrate intake, glycemic index, glycemic load, and risk of postmenopausal breast cancer in a prospective study of French women. Am J Clin Nutr 2008;87:1384–1391.
124.
Larsson SC, Bergkvist L, Wolk A: Glycemic load, glycemic index and breast cancer risk in a prospective cohort of Swedish women. Int J Cancer 2009;125:153–157.
125.
Larsson SC, Giovannucci E, Wolk A: Dietary carbohydrate, glycemic index, and glycemic load in relation to risk of colorectal cancer in women. Am J Epidemiol 2007;165:256–261.
126.
Larsson SC, Bergkvist L, Wolk A: Glycemic load, glycemic index and carbohydrate intake in relation to risk of stomach cancer: a prospective study. Int J Cancer 2006a;118:3167–3169.
127.
Larsson SC, Bergkvist L, Wolk A: Consumption of sugar and sugar-sweetened foods and the risk of pancreatic cancer in a prospective study. Am J Clin Nutr 2006b;84:1171–1176.
128.
Laurson K, Eisenmann JC, Moore S: Lack of association between television viewing, soft drinks, physical activity and body mass index in children. Acta Paediatr 2008;97:795–800.
129.
Lee YP, Mori TA, Puddey IB, et al: Effects of lupin kernel flour-enriched bread on blood pressure: a controlled intervention study. Am J Clin Nutr 2009;89:766–772.
130.
Lee-Han H, Cousins M, Beaton M, et al: Compliance in a randomized clinical trial of dietary fat reduction in patients with breast dysplasia. Am J Clin Nutr 1988;48:575–586.
131.
Levitan EB, Mittleman MA, Håkansson N, Wolk A: Dietary glycemic index, dietary glycemic load, and cardiovascular disease in middle-aged and older Swedish men. Am J Clin Nutr 2007;85:1521–1526.
132.
Libuda L, Alexy U, Sichert-Hellert, et al: Pattern of beverage consumption and long term association with the body weight status in German adolescents – results from the DONALD study. Br J Nutr 2008;99:1370–1379.
133.
Lim S, Zoellner JM, Lee JM, et al: Obesity and sugar-sweetened beverages in African-American preschool children: a longitudinal study. Obesity (Silver Spring) 2009;17:1262–1268.
134.
Lin YC, Lyle RM, McCabe LD, et al: Dairy calcium is related to changes in body composition during a two-year exercise intervention in young women. J Am Coll Nutr 2000;19:754–760.
135.
Lindstrom J, Peltonen M, Eriksson JG, et al: High-fibre, low-fat diet predicts long-term weight loss and decreased type 2 diabetes risk: the Finnish Diabetes Prevention Study. Diabetologia 2006;49:912–920.
136.
Liu S, Chou EL: Dietary glycemic load and type 2 diabetes: modeling the glucose-raising potential of carbohydrates for prevention. Am J Clin Nutr 2010;92:675–677.
137.
Liu S, Willett WC, Manson JE, et al: Relation between changes in intakes of dietary fiber and grain products and changes in weight and development of obesity among middle-aged women. Am J Clin Nutr 2003;78:920–927.
138.
Liu S, Manson JE, Stampfer MJ, et al: A prospective study of whole-grain intake and risk of type 2 diabetes mellitus in US women. Am J Public Health 2000a;90:1409–1415.
139.
Liu S, Willett WC, Stampfer MJ, et al: A prospective study of dietary glycemic load, carbohydrate intake, and risk of coronary heart disease in US women. Am J Clin Nutr 2000b;71:1455–1461.
140.
Livesey G, Taylor R: Fructose consumption and consequences for glycation, plasma triacylglycerol, and body weight: meta-analyses and meta-regression models of intervention studies. Am J Clin Nutr 2008;88:1419–1437.
141.
Livesey G, Taylor R, Hulshof T, Howlett J: Glycemic response and health – a systematic review and meta-analysis: relations between dietary glycemic properties and health outcomes. Am J Clin Nutr 2008;87:258S–268S.
142.
Lock S, Ford MA, Bagley R, Green LF: The effect on plasma lipids of the isoenergetic replacement of table sucrose by dried glucose syrup (maize-syrup solids) in the normal diet of adult men over a period of 1 year. Br J Nutr 1980;43:251–256.
143.
Ludwig DS, Peterson KE, Gortmaker SL: Relation between consumption of sugar-sweetened drinks and childhood obesity: a prospective, observational analysis. Lancet 2001;357:505–508.
144.
Ludwig DS, Pereira MA, Kroenke CH, et al: Dietary fiber, weight gain, and cardiovascular disease risk factors in young adults. JAMA 1999;282:1539–1546.
145.
Lundgren H, Bengtsson C, Blohme G, et al: Dietary habits and incidence of noninsulin-dependent diabetes mellitus in a population study of women in Gothenburg, Sweden. Am J Clin Nutr 1989;49:708–712.
146.
Lutsey PL, Steffen LM, Stevens J: Dietary intake and the development of the metabolic syndrome: The Atherosclerosis Risk in Communities Study. Circulation 2008;117:754–761.
147.
Ma Y, Li Y, Chiriboga DE, et al: Association between carbohydrate intake and serum lipids. J Am Coll Nutr 2006;25:155–163.
148.
Ma Y, Olendzki B, Chiriboga D, et al: Association between dietary carbohydrates and body weight. Am J Epidemiol 2005;161:359–367.
149.
Mack I, Hauner H: Low Carb – kohlenhydratarme Kostformen unter die Lupe genommen. Ernaehrungs Umschau 2007;54:720–726.
150.
Magarey AM, Daniels LA, Boulton TJ, Cockington RA: Does fat intake predict adiposity in healthy children and adolescents aged 2–15 years? A longitudinal analysis. Eur J Clin Nutr 2001;55:471–481.
151.
Malik VS, Popkin BM, Bray GA, et al: Sugar-sweetened beverages and risk of metabolic syndrome and type 2 diabetes: a meta-analysis. Diabetes Care 2010;33:2477–2483.
152.
Malik VS, Willett WC, Hu FB: Sugar-sweetened beverages and BMI in children and adolescents: reanalyses of a meta-analysis. Am J Clin Nutr 2009;89:438–439.
153.
Marett R, Slavin JL: No long-term benefits of supplementation with arabinogalactan on serum lipids and glucose. J Am Diet Assoc 2004;104:636–639.
154.
Marshall JA, Hoag S, Shetterly S, Hamman RF: Dietary fat predicts conversion from impaired glucose tolerance to NIDDM. The San Luis Valley Diabetes Study. Diabetes Care 1994;17:50–56.
155.
Mattes RD, Shikany JM, Kaiser KA, Allison DB: Nutritively sweented beverage consumption and body weight: a systematic review and meta-analysis of randomized experiments. Obes Rev 2010; [Epub ahead of print].
156.
McGee DL, Reed DM, Yano K, et al: Ten-year incidence of coronary heart disease in the Honolulu Heart Program. Relationship to nutrient intake. Am J Epidemiol 1984;119:667–676.
157.
McMillen-Price J, Petocz P, Atkinson F, et al: Comparison of 4 diets of varying glycemic load on weight loss and cardiovascular risk reduction in overweight and obese young adults: a randomized controlled trial. Arch Intern Med 2006;166:1466–1475.
158.
Mellen PB, Walsh T, Herrington D: Whole grain intake and cardiovascular disease: A meta-analysis. Nutr Metab Cardiovasc Dis 2008;18:283–290.
159.
Mendez MA, Pera G, Agudo A, et al: Cereal fiber intake may reduce risk of gastric adenocarcinomas: the EPIC-EURGAST study. Int J Cancer 2007;121:1618–1623.
160.
Mensink RP, Zock PL, Kester AD, Katan MB: Effects of dietary fatty acids and carbohydrates on the ratio of serum total to HDL cholesterol and on serum lipids and apolipoproteins: a meta-analysis of 60 controlled trials. Am J Clin Nutr 2003;77:1146–1155.
161.
Mensink RP, Katan MB: Effect of dietary fatty acids on serum lipids and lipoproteins – a meta-analysis of 27 trials. Arteriosclerosis and Thrombosis 1992;12:911–919.
162.
Mente A, de Koning L, Shannon HS, Anand SS: A systematic review of the evidence supporting a causal link between dietary factors and coronary heart disease. Arch Intern Med 2009;169:659–669.
163.
Meyer KA, Kushi LH, Jacobs DR Jr, et al: Carbohydrates, dietary fiber, and incident type 2 diabetes in older women. Am J Clin Nutr 2000;71:921–930.
164.
Millen BE, Pencina MJ, Kimokoti RW, et al: Nutritional risk and the metabolic syndrome in women: opportunities for preventive intervention from the Framingham Nutrition. Am J Clin Nutr 2006;84:434–441.
165.
Mirmiran P, Noori N, Azizi F: A prospective study of determinants of the metabolic syndrome in adults. Nutr Metab Cardiovasc Dis 2008;18:567–573.
166.
Monterrosa AE, Haffner SM, Stern MP, Hazuda HP: Sex difference in lifestyle factors predictive of diabetes in Mexican-Americans. Diabetes Care 1995;18:448–456.
167.
Montonen J, Jarvinen R, Knekt P, et al: Consumption of sweetened beverages and intakes of fructose and glucose predict type 2 diabetes occurrence. J Nutr 2007;137:1447–1454.
168.
Montonen J, Knekt P, Jarvinen R, et al: Whole-grain and fiber intake and the incidence of type 2 diabetes. Am J Clin Nutr 2003;77:622–629.
169.
Mosdol A, Witte DR, Frost G, et al: Dietary glycemic index and glycemic load are associated with high-density-lipoprotein cholesterol at baseline but not with increased risk of diabetes in the Whitehall II study. Am J Clin Nutr 2007;86:988–994.
170.
Mozaffarian D, Micha R, Wallace S: Effects on coronary heart disease of increasing polyunsaturated fat in place of saturated fat: a systematic review and meta-analysis of randomized controlled trials. PLoS Med 2010;7:e1000252.
171.
Mozaffarian D, Kumanyika SK, Lemaitre RN, et al: Cereal, fruit, and vegetable fiber intake and the risk of cardiovascular disease in elderly individuals. JAMA 2003;289:1659–1666.
172.
Mrdjenovic G, Levitsky DA: Nutritional and energetic consequences of sweetened drink consumption in 6- to 13-year-old children. J Pediatr 2003;142:604–610.
173.
MRI (Max Rubner-Institut): Nationale Verzehrsstudie II. Ergebnissbericht Teil 1. Karlsruhe, 2008;www.was-esse-ich.de/uploads/media/NVSII_Abschlussbericht_Teil_1.pdf (accessed on: April 13, 2010).
174.
Mueller NT, Odegaard A, Anderson K, et al: Soft drink and juice consumption and risk of pancreatic cancer: the Singapore Chinese Health Study. Cancer Epidemiol Biomarkers Prev 2010;19:447–455.
175.
Mulholland HG, Murray LJ, Cardwell CR, Cantwell MM: Glycemic index, glycemic loas, and risk of digestive tract neoplasm: a systematic review and meta-analysis. Am J Clin Nutr 2009;89:568–576.
176.
Mulholland HG, Murray LJ, Cardwell CR, Cantwell MM: Dietary glycaemic index, glycaemic load and breast cancer risk: a systematic review and meta-analysis. Br J Cancer 2008a;99:1170–1175.
177.
Mulholland HG, Murray LJ, Cardwell CR, Cantwell MM: Dietary glycaemic index, glycaemic load and endometrial and ovarian cancer risk: a systematic review and meta-analysis. Br J Cancer 2008b;99:434–441.
178.
Mundt CA, Baxter-Jones AD, Whiting SJ, et al: Relationships of activity and sugar drink intake on fat mass development in youths. Med Sci Sports Exerc 2006;38:1245–1254.
179.
Munoz D: The efficacy of two brief interventions to reduce soda consumption in a college population (Dissertation). State University of New York: Albany, NY, 2006.
180.
National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III): Executive summary of the third report. JAMA 2001;285:2486–2497.
181.
Nettleton JA, Lutsey PL, Wang Y, et al: Diet soda intake and risk of incident metabolic syndrome and type 2 diabetes in the Multi-Ethnic Study of Atherosclerosis (MESA). Diabetes Care 2009;32:688–694.
182.
Newby PK, Peterson KE, Berkey CS, et al: Beverage consumption is not associated with changes in weight and body mass index among low-income preschool children in North Dakota. J Am Diet Assoc 2004;104:1086–1094.
183.
Nicklas TA, Dwyer J, Feldman HA, et al: Serum cholesterol levels in children are associated with dietary fat and fatty acid intake. J Am Diet Assoc 2002;102:511–517.
184.
Nielsen TG, Olsen A, Christensen J, et al: Dietary carbohydrate intake is not associated with the breast cancer incidence rate ratio in postmenopausal Danish women. J Nutr 2005;135:124–128.
185.
Niinikoski H, Lagström H, Jokinen E, et al: Impact of repeated dietary counseling between infancy and 14 years of age on dietary intakes and serum lipids and lipoproteins: the STRIP Study. Circulation 2007;116:1032–1040.
186.
Nissinen K, Mikkilä V, Männistö S, et al: Sweets and sugar-sweetened soft drink intake in childhood in relation to adult BMI and overweight. The Cardiovascular Risk in Young Finns Study. Public Health Nutr 2009;12:2018–2026.
187.
Nöthlings U, Murphy SP, Wilkens LR, et al: Dietary glycemic load, added sugars, and carbohydrates as risk factors for pancreatic cancer: the Multiethnic Cohort Study. Am J Clin Nutr 2007;86:1495–1501.
188.
Nomura AM, Wilkens LR, Murphy SP, et al: Association of vegetable, fruit, and grain intakes with colorectal cancer: the Multiethnic Cohort Study. Am J Clin Nutr 2008;88:730–737.
189.
Nomura AM, Hankin JH, Henderson BE, et al: Dietary fiber and colorectal cancer risk: the multiethnic cohort study. Cancer Causes Control 2007;18:753–764.
190.
Nooyens AC, Visscher TL, Schuit AJ, et al: Effects of retirement on lifestyle in relation to changes in weight and waist circumference in Dutch men: a prospective study. Public Health Nutr 2005;8:1266–1274.
191.
Otani T, Iwasaki M, Ishihara J, et al: Dietary fibre intake and subsequent risk of colorectal cancer: the Japan Public Health Center-based prospective study. Int J Cancer 2006;119:1475–1480.
192.
Oxlund AL, Heitmann BL: Glycaemic index and glycaemic load in relation to blood lipids – 6 years of follow-up in adult Danish men and women. Public Health Nutr 2006;9:737–745.
193.
Palmer JR, Boggs DA, Krishnan S, et al: Sugar-sweetened beverages and incidence of type 2 diabetes mellitus in African American women. Arch Intern Med 2008;168:1487–1492.
194.
Park Y, Brinton LA, Subar AF, Hollenbeck A, Schatzkin A: Dietary fiber intake and risk of breast cancer in postmenopausal women: the National Institutes of Health-AARP Diet and Health Study. Am J Clin Nutr 2009;90:664–671.
195.
Park Y, Hunter DJ, Spiegelman D, et al: Dietary fiber intake and risk of colorectal cancer: a pooled analysis of prospective cohort studies. JAMA 2005;294:2849–2857.
196.
Parker DR, Gonzalez S, Derby CA, et al: Dietary factors in relation to weight change among men and women from two southeastern New England communities. Int J Obes Relat Metab Disord 1997;21:103–109.
197.
Patel AV, McCullough ML, Pavluck AL, et al: Glycemic load, glycemic index, and carbohydrate intake in relation to pancreatic cancer risk in a large US cohort. Cancer Causes Control 2007;18:287–294.
198.
Paynter NP, Yeh HC, Voutilainen S, et al: Coffee and sweetened beverage consumption and the risk of type 2 diabetes mellitus: the atherosclerosis risk in communities study. Am J Epidemiol 2006;164:1075–1084.
199.
Pereira MA, O’Reilly E, Augustsson K, et al: Dietary fiber and risk of coronary heart disease: a pooled analysis of cohort studies. Arch Intern Med 2004;164:370–376.
200.
Philippou E, Bovill-Taylor C, Rajkumar C, et al: Preliminary report: the effect of a 6-month dietary glycemic index manipulation in addition to healthy eating advice and weight loss on arterial compliance and 24-hour ambulatory blood pressure in men: a pilot study. Metabolism 2009;58:1703–1708.
201.
Phillips SM, Bandini LG, Naumova EN, et al: Energy-dense snack food intake in adolescence: longitudinal relationship to weight and fatness. Obes Res 2004;12:461–472.
202.
Priebe MG, van Binsbergen JJ, de Vos R, Vonk RJ: Whole grain foods for the prevention of type 2 dibetes mellitus. Cochrane Database of Systematic Reviews 2008; Issue 1. Art.No: CD006061.
203.
Raben A, Vasilaras TH, Moller AC, Astrup A: Sucrose compared with artificial sweeteners: different effects on ad libitum food intake and body weight after 10 weeks of supplementation in overweight subjects. Am J Clin Nutr 2002;76:721–729.
204.
Rock CL, Flatt SW, Thomson CA, et al; for the Women’s Healthy Eating and Living (WHEL) Study Group: Plasma triacylglycerol and HDL cholesterol concentrations confirm self-reported changes in carbohydrate and fat intakes in women in a diet intervention trial. J Nutr 2004;134:342–347.
205.
Rodearmel SJ, Wyatt HR, Stroebele N, et al: Small changes in dietary sugar and physical activity as an approach to preventing excessive weight gain: the America on the Move family study. Pediatrics 2007;120:869–879.
206.
Rolland-Cachera MF, Deheeger M, Akrout M, Bellisle F: Influence of macronutrients on adiposity development: a follow up study of nutrition and growth from 10 months to 8 years of age. Int J Obes Relat Metab Disord 1995;19:573–578.
207.
Ruottinen S, Rönnemaa T, Niinikoski H, et al: Carbohydrate intake, serum lipids and apolipoprotein E phenotype show association in children. Acta Paediatrica 2009;98:1667–1673.
208.
Ruottinen S, Niinikoski H, Lagström H, et al: High sucrose intake is associated with poor quality of diet and growth between 13 months and 9 years of age: The Special Turku Coronary Risk Factor Intervention Project. Pediatrics 2008;121:e1676–e1685.
209.
Sacks FM, Handysides GH, Marais GE, et al: Effects of a low-fat diet on plasma lipoprotein levels. Arch Intern Med 1986;146:1573–1577.
210.
Sahyoun NR, Anderson AL, Tylavsky FA, et al: Dietary glycemic index and glycemic load and the risk of type 2 diabetes in older adults. Am J Clin Nutr 2008;87:126–131.
211.
Sahyoun NR, Jacques PF, Zhang XL, et al: Whole-grain intake is inversely associated with the metabolic syndrome and mortality in older adults. Am J Clin Nutr 2006;83:124–131.
212.
Salmeron J, Hu FB, Manson JE, et al: Dietary fat intake and risk of type 2 diabetes in women. Am J Clin Nutr 2001;73:1019–1026.
213.
Salmeron J, Ascherio A, Rimm EB, et al: Dietary fiber, glycemic load, and risk of NIDDM in men. Diabetes Care 1997a;20:545–550.
214.
Salmeron J, Manson JE, Stampfer MJ, et al: Dietary fiber, glycemic load, and risk of non-insulin-dependent diabetes mellitus in women. Jama 1997b;277:472–477.
215.
Sandström B, Marckmann P, Bindslev N: An eight-month controlled study of a low-fat high-fibre diet: effects on blood lipids and blood pressure in healthy young subjects. Eur J Clin Nutr 1992;46:95–109.
216.
Saris WH, Astrup A, Prentice AM, et al: Randomized controlled trial of changes in dietary carbohydrate/fat ratio and simple vs complex carbohydrates on body weight and blood lipids: the CARMEN study. The Carbohydrate Ratio Management in European National diets. Int J Obes Relat Metab Disord 2000;24:1310–1318.
217.
Schatzkin A, Mouw T, Park Y, et al: Dietary fiber and whole-grain consumption in relation to colorectal cancer in the NIH-AARP Diet and Health Study. Am J Clin Nutr 2007;85:1353–1360.
218.
Schulz M, Liese AD, Fang F, et al: Is the association between dietary glycemic index and type 2 diabetes modified by waist circumference? Diabetes Care 2006;29:1102–1104.
219.
Schulze MB, Schulz M, Heidemann C, et al: Carbohydrate intake and incidence of type 2 diabetes in the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study. Br J Nutr 2008;99:1107–1116.
220.
Schulze MB, Hoffmann K, Boeing H, et al: An accurate risk score based on anthropometric, dietary, and lifestyle factors to predict the development of type 2 diabetes. Diabetes Care 2007a;30:510–515.
221.
Schulze MB, Schulz M, Heidemann C, et al: Fiber and magnesium intake and incidence of type 2 diabetes: a prospective study and meta-analysis. Arch Intern Med 2007b;167:956–965.
222.
Schulze MB, Liu S, Rimm EB, et al: Glycemic index, glycemic load, and dietary fiber intake and incidence of type 2 diabetes in younger and middle-aged women. Am J Clin Nutr 2004a;80:348–356.
223.
Schulze MB, Manson JE, Ludwig DS, et al: Sugar-sweetened beverages, weight gain, and incidence of type 2 diabetes in young and middle-aged women. Jama 2004b;292:927–934.
224.
Shah M, Adams-Huet B, Garg A: Effect of high-carbohydrate or high-cis-monounsaturated fat diets on blood pressure: a meta-analysis of intervention trials. Am J Clin Nutr 2007;85:1251–1256.
225.
Shin A, Li H, Shu XO, et al: Dietary intake of calcium, fiber and other micronutrients in relation to colorectal cancer risk: Results from the Shanghai Women’s Health Study. Int J Cancer 2006;119:2938–2942.
226.
Sichieri R, Paula Trotte A, de Souza RA, Veiga GV: School randomised trial on prevention of excessive weight gain by discouraging students from drinking sodas. Public Health Nutr 2009;12:197–202.
227.
Sichieri R, Moura AS, Genelhu V, et al: An 18-mo randomized trial of a low-glycemic-index diet and weight change in Brazilian women. Am J Clin Nutr 2007;86:707–713.
228.
Siewert JR, Ott K: Are squamous and adenocarcinomas of the esophagus the same disease? Semin Radiat Oncol 2007;17:38–44.
229.
Simons-Morton DG, Hunsberger SA, Van Horn L, et al: Nutrient intake and blood pressure in the Dietary Intervention Study in Children. Hypertension 1997;29:930–936.
230.
Siri-Tarino PW, Sun Q, Hu FB, Krauss RM: Meta-analysis of prospective cohort studies evaluating the association of saturated fat with cardiovascular disease. Am J Clin Nutr 2010;91:535–546.
231.
Skinner JD, Bounds W, Carruth BR, et al: Predictors of children’s body mass index: a longitudinal study of diet and growth in children aged 2–8 years. Int J Obes Relat Metab Disord 2004;28:476–482.
232.
Skinner JD, Bounds W, Carruth BR, Ziegler P: Longitudinal calcium intake is negatively related to children’s body fat indexes. J Am Diet Assoc 2003;103:1626–1631.
233.
Sloth B, Krog-Mikkelsen I, Flint A, et al: No difference in body weight decrease between a low-glycemic-index and a high-glycemic-index diet but reduced LDL cholesterol after 10-weeks ad libitum intake of the low-glycemic-index diet. Am J Clin Nutr 2004;80:337–347.
234.
Sluijs I, van der Schouw YT, van der AD, et al: Carbohydrate quantity and quality and risk of type 2 diabetes in the European Prospective Investigation into Cancer and Nutrition-Netherlands (EPIC-NL) study. Am J Clin Nutr 2010;92:905–911.
235.
Stamler J, Liu K, Ruth KJ, et al: Eight-year blood pressure change in middle-aged men: relationship to multiple nutrients. Hypertension 2002;39:1000–1006.
236.
Stamler J, Caggiula AW, Grandits GA: Relation of body mass and alcohol, nutrient, fiber, and caffeine intakes to blood pressure in the special intervention and usual care groups in the Multiple Risk Factor Intervention Trial. Am J Clin Nutr 1997;65(1 suppl):338–365.
237.
Stanhope KL, Schwarz JM, Keim NL, et al: Consuming fructose-sweetened, not glucose-sweetened, beverages increases visceral adiposity and lipids and decreases insulin sensitivity in overweight/obese humans. J Clin Invest 2009;119:1322–1334.
238.
Steffen LM, Kroenke CH, Yu X, et al: Associations of plant food, dairy product, and meat intakes with 15-years incidence of elevated blood pressure in young black and white adults: the Coronary Artery Risk Development in Young Adults (CARDIA) Study. Am J Clin Nutr 2005;82:1169–1177.
239.
Stehle P, Oberritter H, Büning-Fesel M, Heseker H: Grafische Umsetzung von Ernährungsrichtlinien – traditionelle und neue Ansätze. Ernaehrungs Umschau 2005;52:128–135.
240.
Stevens J, Ahn K, Juhaeri, et al: Dietary fiber intake and glycemic index and incidence of diabetes in African-American and white adults: the ARIC study. Diabetes Care 2002;25:1715–1721.
241.
Strayer L, Jacobs DR Jr, Schairer C, et al: Dietary carbohydrate, glycemic index, and glycemic load and the risk of colorectal cancer in the BCDDP cohort. Cancer Causes Control 2007;18:853–863.
242.
Streppel MT, Ocké MC, Boshuizen HC, et al: Dietary fiber intake in relation to coronary heart disease and all-cause mortality over 40 years: the Zutphen Study. Am J Clin Nutr 2008;88:1119–1125.
243.
Streppel MT, Arends LR, van ‘t Veer P, et al: Dietary fiber and blood pressure: a meta-analysis of randomized placebo-controlled trials. Arch Intern Med 2005;165:150–156.
244.
Striegel-Moore RH, Thompson D, Affenito SG, et al: Correlates of beverage intake in adolescent girls: the National Heart, Lung, and Blood Institute Growth and Health Study. J Pediatr 2006;148:183–187.
245.
Suzuki R, Rylander-Rudqvist T, Ye W, et al: Dietary fiber intake and risk of postmenopausal breast cancer defined by estrogen and progesterone receptor status – a prospective cohort study among Swedish women. Int J Cancer 2008;122:403–412.
246.
Swarbrick MM, Stanhope KL, Elliot SS, et al: Consumption of fructose-sweetened beverages for 10 weeks increases postprandial triacylglycerol and apolipoprotein-B concentrations in overweight and obese women. Br J Nutr 2008;100:947–952.
247.
Tai ES, Fok AC, Chu R, Tan CE: A study to assess the effect of dietary supplementation with soluble fibre (Minolest) on lipid levels in normal subjects with hypercholesterolaemia. Ann Acad Med Singapore 1999;28:209–213.
248.
Talati R, Baker WL, Pabilonia MS, et al: The effects of barley-derived soluble fiber on serum lipids. Ann Fam Med 2009;7:157–163.
249.
Tam CS, Garnett SP, Cowell CT, et al: Soft drink consumption and excess weight gain in Australian school students: results from the Nepean study. Int J Obes (Lond) 2006;30:1091–1093.
250.
Tappy L, Le K-A: Metabolic effects of fructose and the worldwide increase in obesity. Physiol Rev 2010;90:23–46.
251.
Thomas DE, Elliott EJ, Baur L: Low glycaemic index or low glycaemic load diets for overweight and obesity (Review). Cochrane Database of Systematic Reviews 2007; Issue 3. Art. No: CD005105.
252.
Tillotson JL, Grandits GA, Bartsch GE, Stamler J: Relation of dietary carbohydrates to blood lipids in the special intervention and usual care groups in the Multiple Risk Factor Intervention. Am J Clin Nutr 1997a;65:314–326.
253.
Tillotson JL, Grandits GA, Bartsch GE, Stamler J: Relation of dietary fiber to blood lipids in the special intervention and usual care groups in the Multiple Risk Factor Intervention Trial. Am J Clin Nutr 1997b;65:327–337.
254.
Tinker LF, Bonds DE, Margolis KL, et al: Low-fat dietary pattern and risk of treated diabetes mellitus in postmenopausal women: the Women’s Health Initiative randomized controlled dietary modification trial. Arch Intern Med 2008;168:1500–1511.
255.
Tordoff MG, Alleva AM: Effect of drinking soda sweetened with aspartame or high-fructose corn syrup on food intake and body weight. Am J Clin Nutr 1990;51:963–969.
256.
Tucker LA, Thomas KS: Increasing total fiber intake reduces risk of weight and fat gains in women. J Nutr 2009;139:576–581.
257.
Twisk JW, Kemper HC, van Mechelen W, et al: Body fatness: longitudinal relationship of body mass index and the sum of skinfolds with other risk factors for coronary heart disease. Int J Obes Relat Metab Disord 1998;22:915–922.
258.
Twisk JW, Kemper HC, van Mechelen W, Post GB: Which lifestyle parameters discriminate high- from low-risk participants for coronary heart disease risk factors. Longitudinal analysis covering adolescence and young adulthood. J Cardiovasc Risk 1997;4:393–400.
259.
van Bakel MM, Kaaks R, Feskens EJ, et al: Dietary glycaemic index and glycaemic load in the European Prospective Investigation into Cancer and Nutrition. Eur J Clin Nutr 2009;63:S188–S205.
260.
van Dam RM, Seidell JC: Carbohydrate intake and obesity. Eur J Clin Nutr 2007;61(suppl 1):75–99.
261.
van Dam RM, Rimm EB, Willett WC, et al: Dietary patterns and risk for type 2 diabetes mellitus in U.S. men. Ann Intern Med 2002;136:201–209.
262.
van Dam RM, Visscher AWJ, Feskens EJM: Dietary glycemic index in relation to metabolic risk factors and incidence of coronary heart disease: the Zutphen Elderly Study. Eur J Clin Nutr 2000;54:726–731.
263.
van Lenthe FJ, van Mechelen W, Kemper HC, Post GB: Behavioral variables and development of a central pattern of body fat from adolescence into adulthood in normal-weight whites: the Amsterdam Growth and Health Study. Am J Clin Nutr 1998;67:846–852.
264.
Vanselow MS, Pereira MA, Neumark-Sztainer D, Raatz SK: Adolescent beverage habits and changes in weight over time: findings from Project EAT. Am J Clin Nutr 2009;90:1489–1495.
265.
van Wymelbeke V, Beridot-Therond ME, de La Gueronniere V, Fantino M: Influence of repeated consumption of beverages containing sucrose or intense sweeteners on food intake. Eur J Clin Nutr 2004;58:154–161.
266.
Vartanian LR, Schwartz MB, Brownell KD: Effects of soft drink consumption on nutrition and health: a systematic review and meta-analysis. Am J Public Health 2007;97:667–675.
267.
Vartiainen E, Puska P, Pietinen P, et al: Effects of dietary fat modifications on serum lipids and blood pressure in children. Acta Paediatr Scand 1986;75:396–401.
268.
Ventura AK, Loken E, Brich LL: Risk profiles for metabolic syndrome in a nonclinical sample of adolescent girls. Pediatrics 2006;118:2434–2442.
269.
Villegas R, Liu S, Gao YT, et al: Prospective study of dietary carbohydrates, glycemic index, glycemic load, and incidence of type 2 diabetes mellitus in middle-aged Chinese women. Arch Intern Med 2007;167:2310–2316.
270.
Wakai K, Date C, Fukui M, et al: Dietary fiber and risk of colorectal cancer in the Japan collaborative cohorte study. Cancer Epidemiol Biomarkers Prev 2007;16:668–675.
271.
Walter U, Schwartz FW: Prävention; in Schwartz FW, Badura B, Busse R, et al. (eds): Das Public Health Buch. Urban and Fischer Verlag. München, Jena 2003, pp S189–S214.
272.
Wang L, Gaziano JM, Liu S, et al: Whole- and refined-grain intakes and the risk of hypertension in women. Am J Clin Nutr 2007;86:472–479.
273.
Wannamethee SG, Whincup PH, Thomas MC, Sattar N: Associations between dietary fiber and inflammation, hepatic function, and risk of type 2 diabetes in older men: potential mechanisms for the benefits of fiber on diabetes risk. Diabetes Care 2009;32:1823–1825.
274.
Weijenberg MP, Mullie PF, Brants HA, et al: Dietary glycemic load, glycemic index and colorectal cancer risk: results from the Netherlands Cohort Study. Int J Cancer 2008;122:620–629.
275.
Wen W, Shu XO, Li H, et al: Dietary carbohydrates, fiber, and breast cancer risk in Chinese women. Am J Clin Nutr 2009;89:283–289.
276.
Whelton SP, Hyre AD, Pedersen B, et al: Effect of dietary fiber intake on blood pressure: a meta-analysis of randomized, controlled clinical trials. J Hypertens 2005;23:475–481.
277.
WHO: Global health risks: Mortality and burden of disease attributable to selected major risks. World Health Organization Geneva, 2009.
278.
WHO: Diet, nutrition and the prevention of chronic diseases. World Health Organisation (WHO), Technical Report Series 916, 2003.
279.
Williams CL, Strobino BA: Childhood Diet, Overweight, and CVD Risk Factors: The Healthy Start Project. Prev Cardiol 2008;11:11–20.
280.
Williams DE, Knowler WC, Smith CJ, et al: The effect of Indian or Anglo dietary preference on the incidence of diabetes in Pima Indians. Diabetes Care 2001;24:811–816.
281.
Witteman JC, Willett WC, Stampfer MJ, et al: A prospective study of nutritional factors and hypertension among US women. Circulation 1989;80:1320–1327.
282.
World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR): Food, nutrition, physical activity and the prevention of cancer: a global perspective. American Institute for Cancer Research, Washington DC, 2007.
283.
Wu H, Dwyer KM, Fan Z, et al: Dietary fiber and progression of atherosclerosis: the Los Angeles Atherosclerosis Study. Am J Clin Nutr 2003;78:1085–1091.
284.
Yano K, Rhoads GG, Kagan A, Tillotson J: Dietary intake and the risk of coronary heart disease in Japanese men living in Hawaii. Am J Clin Nutr 1978;31:1270–1279.
285.
Zhang X, Albanes D, Beeson WL, et al: Risk of colon cancer and coffee, tea, and sugar-sweetened soft drink intake: pooled analysis of prospective cohort studies. J Natl Cancer Inst 2010;102:771–783.
286.
Zhang C, Liu S, Solomon CG, Hu FB: Dietary fiber intake, dietary glycemic load, and the risk for gestational diabetes mellitus. Diabetes Care 2006;29:2223–2230.
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2012
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