Aim: To evaluate the effect of pomegranate juice on insulin secretion and sensitivity in patients with obesity. Methods: A randomized, double-blind, placebo-controlled clinical trial was carried out in 20 obese, adult volunteer subjects. After random allocation of the intervention, 10 patients received 120 ml of pomegranate juice or placebo while in a fasted state for 1 month. Glucose, uric acid, creatinine, lipid profile, and insulin were measured at baseline, and glucose and insulin were also measured at 30, 60, 90, and 120 min. The area under the curve of glucose and insulin, total insulin secretion, and insulin sensitivity was calculated. Results: There was a significant increase in weight, body mass index, and fat mass in the placebo group after the intervention. Insulin secretion and insulin sensitivity were not modified with administration of pomegranate juice. There was a significant difference in changes from baseline in fat mass between groups (1.1 ± 1.1% vs. –1.4 ± 3.0%, p = 0.010; placebo and pomegranate groups, respectively). Conclusion: Pomegranate juice administration for 1 month did not modify insulin secretion and sensitivity in patients with obesity; however, the natural evolution to increased weight and adiposity was halted.

1.
Avenell A, Broom J, Brown TJ, et al: Systematic review of the long-term effects and economic consequences of treatments for obesity and implications for health improvement. Health Technol Assess 2004;8:1–182.
2.
Low S, Chin MC, Deurenberg-Yap M: Review on epidemic of obesity. Ann Acad Med Singapore 2009;38:57–65.
3.
Rucker D, Padwal R, Li SK, Curioni C, Lau DC: Long-term pharmacotherapy for obesity and overweight: updated meta-analysis. BMJ 2007;335:1194–1199.
4.
Jurenka J: Therapeutic applications of pomegranate (Punica granatum L.): a review. Altern Med Rev 2008;13:128–144.
5.
McFarlin BK, Strohacker KA, Kueht ML: Pomegranate seed oil consumption during a period of high-fat feeding reduces weight gain and reduces type 2 diabetes risk in CD-1 mice. Br J Nutr 2009;102:54–59.
6.
Albreda I, Rodríguez-Espinoza J, Murugo M, de Leiva A, Corcoy R: Assessment of insulin sensitivity and beta-cell function from measurements in the fasting state during an oral glucose tolerance test. Diabetologia 2000;43:1507–1511.
7.
Jeyaseelan L, Rao PSS: Methods of determining sample sizes in clinical trial. Indian Pediatr 1989;26:115–121.
8.
Singh RP, Chidambara-Murthy KN, Jayaprakasha GK: Studies on the antioxidant activity of pomegranate (Punica granatum) peel and seed extracts using in vitro models. J Agric Food Chem 2002;50:81–86.
9.
Lei F, Zhang XN, Wang W, et al: Evidence of anti-obesity effects of the pomegranate leaf extract in high-fat diet induced obese mice. Int J Obes (Lond) 2007;31:1023–1029.
10.
Pajunen P, Vartiainen E, Männistö S, Jousilahti P, Laatikainen T, Peltonen M: Intra-individual changes in body weight in population-based cohorts during four decades: the Finnish FINRISK study. Eur J Public Health 2010, DOI: 10.1093/eurpub/ckq182.
11.
Louba BN: What are the medical properties of pomegranates? J Chin Clin Med 2007;2:530–538.
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.