Caloric restriction (CR) is widely used to study aging processes. It is a simple and highly reproducible method for delaying the aging process, preventing the onset of aging-related diseases and extending average or maximum lifespan. However, the mechanism underlying these effects of CR is still not clear. CR can inhibit growth, reduce body size and maintain a low body temperature. At the same time, there is a measurable decrease in the volume of adipose tissue, hyperglycemia and hyperinsulinemia, accompanied by modifications of lipid and energy metabolism and increased resistance to endogenous and extraneous stress. The metabolic changes induced by dietary restriction, the inhibition of fat deposition in nonadipose tissue and the effects on signal transduction are considered the most likely candidates for mechanisms underlying the effects of CR.

Keywords:
Caloric restriction, Aging, Lifespan, Energy metabolism
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