EPIC is among the largest cohort studies, with approximately 475,000 study participants, on the etiological influence of diet and chronic diseases. During a 4-year recruitment period, two German EPIC centers, located in Heidelberg and Potsdam, aimed to recruit a total of 60,000 study participants from the local populations. The recruitment process was based on addresses from general population registries and started 4–5 weeks in advance with an initial invitation by mail to the basic examination for this study. Subjects not responding within 2 weeks were reminded. In Potsdam, this was done by mail and telephone, and in Heidelberg by telephone. During the recruitment phase, from 1994 to 1998, 53,162 subjects in total were examined for the cohort studies in Heidelberg (n = 25,546) and Potsdam (n = 27,616). The participation rate, compared to the invited number of subjects, was 22.7% in Potsdam and 38.3% in Heidelberg, with a considerable variation by municipality and gender. A comparison with data from the National Health Survey 1991/1992 revealed that the cohort populations were of higher socio-economic status and were healthier than the source population. We concluded that the selective participation would help to ensure high maintenance of the cohort during active follow-up. Selective participation does not harm etiological conclusions because disease associations are derived internally as relative risk. The relative risk estimates can be used to calculate population-attributable risk and preventable proportion, based on exposure prevalence derived by surveys and other studies.

This content is only available via PDF.
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.