The effect of long-term administration of acetaminophen to rats on the dietary protein utilization was investigated using protein-sufficient and protein-deficient diets. Fat digestibility, food efficiency and some hepatic parameters were also determined. Results showed that there was a significant decrease in the nitrogen metabolic utilization in the protein-sufficient treated animals compared to the untreated group (0.59 ± 0.03 vs. 0.75 ± 0.03, p < 0.001). The protein-deficient diet and the administration of the drug resulted in lower nitrogen metabolic utilization in either of the two metabolic balances (days 4–11 and 36–42). These changes were not accompanied by variations in the nitrogen digestibility coefficient.

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