The influence of a supplement of linseed oil (LO), rich in linoleic acid (C18:3, n-3), was compared with one offish oil (MaxEPA) rich in eicosapentaenoic acid (C20:5, n-3) and docosahexaenoic acid (22:6, n-3) on blood and tissue lipids in weanling rats receiving a high intake of linoleic acid. Both the LO and the MaxEPA supplement decreased plasma cholesterol concentrations. The MaxEPA supplement but not the linseed oil supplement also decreased the concentrations of plasma triglycerides and HDL cholesterol. The proportion of C20:5, n-3 was markedly increased in the platelet and erythrocyte lipids by the MaxEPA supplement but not in tissue lipids. However, the increase in the proportion of C20:5, n-3 in the platelet was small compared with other studies. Both supplements led to an increase in the proportion of C22:6, n-3 in blood and tissue lipids but the MaxEPA supplement was more potent than the LO supplement. The most marked change was observed in the heart lipids. These changes were accompanied by reciprocal changes in the proportions of arachidonic, adrenic and docosapentaenoic acid.

Keywords:
Fatty acids, n-3 polyunsaturated, Linoleic acid, Supplements, Blood and tissue lipids, Rat
This content is only available via PDF.
© 1985 S. Karger AG, Basel
1985
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.