In order to study the influence of varying vitamin B6 intake levels on the reproductive performance and the vitamin B6 status of fetuses and reproductive organs, 30 pregnant rats (Sprague Dawley strain) were fed a semisynthetic casein diet supplemented with 1,6, 12, 24 and 48 mg vitamin B6/kg throughout pregnancy. On days 19 of pregnancy the rats were killed. Fetuses, placenta, amniotic fluid, amnion, uterus and mammary gland were analysed microbiologically for their vitamin B6 content. Reproductive performance was not influenced by the dietary treatment. Vitamin B6 concentrations in fetuses, placenta and amniotic fluid of mothers treated with the low 1-ppm vitamin B6 diet were significantly decreased. At a vitamin B6 supply of 6 ppm, however, tissue saturation was already reached in these organs. Accordingly, the whole vitamin B6 retention in the reproductive product plateaued at an intake level of 6 ppm vitamin B6 at 37 µg vitamin B6 per animal. These results indicate therefore that a level of 6 ppm dietary vitamin B6 is sufficient to guarantee an optimum vitamin B6 status in the reproductive product, and higher vitamin B6 supplementations showed no further effect on the parameters investigated.

This content is only available via PDF.
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.