Na+, K+-ATPase was studied in developing rat brain during undernutrition. The activity of Na+, K+-ATPase was significantly lower in animals that were undernourished from 6 to 17 days after birth than in well-nourished controls. The decreased activity of the enzyme was partially recovered after 4 weeks of rehabilitation. No change in the cation contents of brain following undernutrition was observed. The decrease in Na+, K+-ATPase activity was possibly due to the reduction in cholesterol contents and could be responsible for the observed functional changes associated with malnutrition or undernutrition during development.

Keywords:
Na+, K+-ATPase, Developing rat brain, Undernutrition, Ouabain, Brain, lipids
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© 1980 S. Karger AG, Basel
1980
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