We have investigated whether the earlier-found decreased unsaturation in mitochondrial membranes in vitamin E deficiency affects the permeability properties of mitochondria. The iso-osmotic swelling technique was used as a measure for the rate of uptake of substrates by these organelles. A significantly slower uptake could be observed of ammonium malate in the presence of phosphate and of ammonium phosphate. These changes in membrane permeability might give a clue to the mechanism of some metabolic abnormalities as seen in vitamin E deficiency in relating these abnormalities to specific membrane functions, e.g. an affection of carriers; for instance the phosphate carrier.

Keywords:
Vitamin E deficiency, Membranes, Phosphate transport
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© 1975 S. Karger AG, Basel
1975
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