The uptake of ascorbic acid by the organs of near-scorbutic guinea-pigs was examined. Tissue saturation was achieved in the liver, spleen, heart and adrenals 24 h after the administration of 1 % ascorbic acid in the drinking water; saturation of the eye lens, testes and brain was less rapid. A transient ‘supersaturation’ of 5 days’ duration occurred in the liver, spleen and heart. It is suggested that supersaturation, if it occurs in man, could effect a partial invalidation of the classical ‘saturation test’ for ascorbic acid insufficiency.

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