The 125I-fibrinogen uptake test was used in rabbits after the production of thrombosis in the marginal ear vein. The uptake was very similar with thrombosis produced by irritants, thrombin as well as with inflammation without thrombosis. The 131I-albumin accumulated under these conditions to the same exten or even more than 125I-fibrinogen. The local increase of permeability seemed to represent the most important factor in the uptake of both 125I-fibrinogen und 131I-albumin.

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