... to the general population. Hyperphosphataemia, associated with vascular calcification and arterial stiffness, may play a key role in the pathogenesis of cardiovascular disease (CVD) associated with CKD, although phosphate reduction strategies have not consistently proven to beneficially affect clinically...

..., instructions or products referred to in the content or advertisements. Visual Abstract Visual Abstract. Vascular calcification Cardiovascular disease Kidney transplant Simultaneous pancreas-kidney transplant Mortality Patients with chronic kidney disease (CKD) have...

...Beini Lyu; Tanushree Banerjee; Julia J. Scialla; Tariq Shafi; Alexander S. Yevzlin; Neil R. Powe; Rulan S. Parekh; Brad C. Astor Background: Arteriovenous (AV) access dysfunction is a common complication in hemodialysis patients. Markers of vascular calcification are associated with cardiovascular...

..., and Id3 [ 19 ]. We hypothesized that BMP signaling is a stimulus for vascular calcification in patients with calciphylaxis. In previous studies, Kramann et al. [ 20 ] and Tian et al. [ 21 ] detected upregulation of BMP-2, a BMP receptor ligand, in patients with calciphylaxis. Griethe et al. [ 22...

...(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Vascular calcification Osteoprotegerin Peritoneal dialysis Diabetes mellitus Arterial calcification...

... test to compare differences between groups. Differences between 2 groups were analyzed using a Student's t test. p values <0.05 were considered statistically significant. Analysis was performed using GraphPad Prism version 5. Chronic kidney disease Vitamin K Vascular calcification...

...Yin-na Wang; Yi Sun; Ying Wang; Yan-li Jia Background/Aim: Vascular calcification is common and contributes to increased cardiovascular mortality in hemodialysis (HD) patients. In this prospective study, we aimed to investigate the associations of serum S100A12 in the presence of severe coronary...

...Li Yao; Yi-ting Sun; Wei Sun; Tian-hua Xu; Chuang Ren; Xing Fan; Li Sun; Lin-lin Liu; Jiang-min Feng; Jian-fei Ma; Li-ning Wang Aims: Vascular calcification is a risk factor for causing cardiovascular events and has a high prevalence among chronic kidney disease (CKD) patients. However...

... cause of death with a functioning graft, ranging from 36 to 55%. The impact of vascular calcification (VC) on morbidity and mortality of KTRs is not appreciated enough nowadays. Summary: This review summarizes 13 important studies on VC in KTRs, comparing the results with CKD and dialysis populations...

... to by the CKD-mineral bone disorder (CKD-MBD). CKD-MBD begins in early CKD and its vascular manifestations begin with vascular stiffness proceeding to increased carotid artery intima-media thickness (cIMT) and vascular calcification (VC). Phosphorus is associated with this progression and is considered a CVD...

.... Given the importance of the ECM in vascular calcification we tested the hypothesis that increased TGM2 activity may accelerate vascular calcification in chronic kidney disease (CKD). Methods: We utilized thoracic aortas and vascular smooth muscle cells (VSMC) from the Cy/+ rat, a model of progressive...

... with vascular calcification. Hyperphosphatemia is an essential risk factor for increased vascular calcification. End-stage renal disease (ESRD) patients could serve as an in vivo model for accelerated calcification. This study focuses on the most likely protective effects of magnesium ion (Mg 2+ ) on phosphate...

... calcification have been associated with increased cardiovascular morbidity and mortality in different patient populations including patients with chronic kidney disease (CKD). In the present study, we aimed to elucidate the association of vascular calcification with corrected QT interval duration in patients...

... or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Calciphylaxis Calcific uremic arteriolopathy Vascular calcification Calciphylaxis [calcific uremic arteriolopathy (CUA)] is a well-described but poorly understood disorder...

...Tineke M. De Schutter; Ellen Neven; Veerle P. Persy; Geert J. Behets; Andrei A. Postnov; Nora M. De Clerck; Patrick C. D’Haese Background: Increased bone loss has been associated with the development of vascular calcification in patients with chronic renal failure (CRF). In this study, the effect...

... to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Matrix metalloproteinase Gelatinase Vascular calcification Chronic kidney disease National Institutes of Health (NIH) 10.13039/100000002 Vascular...

...Santhosh Jay Mathews; Lisa de las Fuentes; Prashanth Podaralla; Anton Cabellon; Sijie Zheng; Andrew Bierhals; Karen Spence; Eduardo Slatopolsky; Victor G. Davila-Roman; James A. Delmez Background and Objectives: Vascular calcification is a major contributor to morbidity and mortality...

... related to all-cause and cardiovascular mortality in dialysis patients. Our aim is to investigate the association between the genetic polymorphism of α 2 -Heremans-Schmid-glycoprotein (AHSG) encoding fetuin-A and its serum concentration, vascular calcification, and aortic stiffness in peritoneal dialysis...

...Navid Shobeiri; Michael A. Adams; Rachel M. Holden Vascular calcification is a significant contributor to the cardiovascular mortality observed in chronic kidney disease (CKD). This review discusses the animal models (5/6 nephrectomy, mouse electrocautery model and dietary adenine) that have been...

...Masanori Tokumoto; Masahide Mizobuchi; Jane L. Finch; Hironori Nakamura; Daniel R. Martin; Eduardo Slatopolsky Background/Aims: Hyperphosphatemia is associated with vascular calcification and increased cardiovascular morbidity and mortality. Angiotensin-converting enzyme inhibitors are beneficial...