...Seok Hui Kang; Bo Yeon Kim; Eun Jung Son; Gui Ok Kim; Jun Young Do Introduction: There were insufficient pieces of evidence regarding the effect of the two drugs (allopurinol and febuxostat) on patient survival in hemodialysis (HD) patients. Herein, we aimed to compare the efficacy of uric acid...

... by one-way ANOVA. Linear regressions were performed to control for demographics, comorbidities, and stone composition. Results: With lower eGFR, the proportion of calcium stones declined while uric acid (UA) stones increased. On univariable analysis, lower eGFR was associated with lower urine pH, calcium...

...Kenji Maki; Jun Hata; Satoko Sakata; Emi Oishi; Yoshihiko Furuta; Toshiaki Nakano; Yoshinao Oda; Takanari Kitazono; Toshiharu Ninomiya Introduction: Information regarding the influence of serum uric acid (SUA) levels on pathological changes in the kidney is limited. In this study, we examined...

...Yuki Okada; Shinichiro Uehara; Mikiko Shibata; Hideo Koh; Keiko Oue; Hiroshi Kambe; Michio Morimoto; Kyoko Kogawa Sato; Tomoshige Hayashi Background: Previous studies showed that higher serum uric acid levels increased the risk of chronic kidney disease (CKD), but moderate alcohol consumption...

...Bin Zhu; Dong-rong Yu; Ji-cheng Lv; Yi Lin; Qiang Li; Jia-zhen Yin; Yuan-yuan Du; Xuan-li Tang; Li-chan Mao; Qiu-fen Li; Yue Sun; Ling Liu; Xian-fa Li; Dan Fei; Xin-yi Wei; Cai-feng Zhu; Xiao-xia Cheng; Hong-yu Chen; Yong-jun Wang Background: The role of serum uric acid (SUA) level...

... the relationship is causal. We examined the association of hyperuricemia and uric acid lowering therapy (UALT) with progression of CKD in patients with CKD 3 and 4 in the Cleveland Clinic CKD registry. Methods: We included 1,676 patients with CKD stages 3 and 4 from Ohio, who had measured their uric acid (UA...

...Masanari Kuwabara; Petter Bjornstad; Ichiro Hisatome; Koichiro Niwa; Carlos A. Roncal-Jimenez; Ana Andres-Hernando; Thomas Jensen; Tamara Milagres; Yuka Sato; Gabriela Garcia; Minoru Ohno; Miguel A. Lanaspa; Richard J. Johnson Background: While elevated serum uric acid level (SUA) is a recognized...

...A. Ahsan Ejaz; Kawther F. Alquadan; Bhagwan Dass; Michiko Shimada; Mehmet Kanbay; Richard J. Johnson Background: The aim of the study was to investigate the effects of serum uric acid (SUA) on acute kidney injury (AKI) in patients undergoing cardiac surgery. Methods: Prospectively collected data...

... defined as a serum uric acid level of ≤2 mg/dl, is considered a biochemical disorder with no clinical significance. However, individuals with renal hypouricemia have a high risk of urolithiasis and exercise-induced acute kidney injury, both of which are risk factors for reduced kidney function. Methods...

... dysfunction', ‘endothelial function' with the key words ‘xanthine oxidase inhibitor', ‘uric acid', ‘hyperuricemia', and ‘oxypurinol'. Our search was limited to studies in humans and in peer-reviewed journals from January 1985 to July 2013 without language restriction. In addition, we searched other...

... the structure and function of the microbiome. Recently, we found marked differences in the abundance of numerous bacterial taxa between ESRD and healthy individuals. Influx of urea and uric acid and dietary restriction of fruits and vegetables to prevent hyperkalemia alter ESRD patients' intestinal milieu. We...

... patients who underwent PCI. Results: Of the 3,201 patients who underwent PCI and for whom data were available regarding their baseline serum uric acid level, 763 (23.8%) had hyperuricemia. The hyperuricemia-associated hazard ratios (HRs) [95% confidence intervals (CIs)] for all-cause mortality were 1.780...

... for cardiovascular (CV) disease and is also associated with elevated uric acid, which is emerging as a nontraditional CV risk factor. We therefore evaluated uric acid as a risk factor for CV disease in subjects presenting to nephrologists with CKD who were not on medications known to alter endothelial function...

...Baris Afsar; Rengin Elsurer; Adrian Covic; Richard J. Johnson; Mehmet Kanbay Background: Elevated serum uric acid has been associated with cognitive dysfunction and vascular cognitive impairment in the elderly. Serum uric acid is also commonly elevated in chronic kidney disease (CKD), but its...

...Hiroo Sonoda; Hiroyuki Takase; Yasuaki Dohi; Genjiro Kimura Aims: Increased uric acid levels are associated with kidney dysfunction. We tested the hypothesis that uric acid level predicts future development of chronic kidney disease (CKD) in the general population. Methods: For this study, we...

...Mehmet Kanbay; Mustafa Ikizek; Yalcin Solak; Yusuf Selcoki; Sema Uysal; Ferah Armutcu; Beyhan Eryonucu; Adrian Covic; Richard J. Johnson Background and Objectives: Cardiovascular disease is prevalent in chronic kidney disease (CKD). Uric acid is increased in subjects with CKD and has been linked...

...Mehmet Kanbay; Mahmut Ilker Yilmaz; Alper Sonmez; Faruk Turgut; Mutlu Saglam; Erdinc Cakir; Mujdat Yenicesu; Adrian Covic; Diana Jalal; Richard J. Johnson Background: An elevated serum uric acid level is strongly associated with endothelial dysfunction and inflammation, both of which are common...

... loci for serum uric acid (UA) levels. We also identified a common nonsense mutation, W258X, responsible for renal hypouricemia. Here, we investigated clinical implications of these genetic variants by cross-sectional and longitudinal genetic epidemiological analysis. Methods: The study enrolled 5,165...

... levels comparable to those in the controls within 90 days. In a time-dependent multivariate analysis, this decrease was predicted by changes in GFR, MAP, and uric acid levels. Conclusion: Our data does not exclude IMT as a predictor of mortality in CKD, but suggests that other etiologies than...

...A. Ahsan Ejaz; Thomas M. Beaver; Michiko Shimada; Puneet Sood; Vijaykumar Lingegowda; Jesse D. Schold; Tad Kim; Richard J. Johnson Background: Uric acid has been reported to be a risk factor for the development of chronic kidney disease; however, no study has examined whether uric acid may confer...