...Li Qin Gao; Can Can Xue; Jing Cui; Jie Xu; Chun Zhang; Dong Ning Chen; Jost B. Jonas; Ya Xing Wang Introduction: The aim of the study was to investigate associations between diabetic retinopathy (DR) and chronic kidney disease (CKD) in patients with type 2 diabetes (TD2). Methods: The participants...

...Gwo-Tsann Chuang; Daan Kremer; Chi-Hsuan Huang; Firas F. Alkaff; Chih-Hung Lin; Tzu-Ling Tseng; Gozewijn D. Laverman; Stephan J. L. Bakker; Lee-Ming Chuang Introduction: There is a great clinical need for novel markers to predict kidney function decline in patients with type 2 diabetes. We explored...

... cardiorenal outcomes in patients with chronic kidney disease and type 2 diabetes (T2D). This post hoc analysis explores finerenone in patients from the Asian region. Methods: In FIDELIO-DKD, 5,674 patients with T2D and urine albumin-to-creatinine ratio (UACR) ≥30–<300 mg/g and estimated glomerular...

...João Pedro Ferreira; Patrick Rossignol; George Bakris; Cyrus Mehta; William B. White; Faiez Zannad Introduction: Worsening kidney function (WKF) is frequent among patients with type 2 diabetes (T2D) and a recent acute coronary syndrome (ACS) and is associated with a poor prognosis. An accurate...

... in patients with type 2 diabetes (T2D) to diagnose non-diabetic or hypertensive kidney disease (NDHKD) potentially requiring specific management compared to diabetic and or hypertensive nephropathy (absence of NDHKD). Indications for KB are based on the presence of atypical features compared to the typical...

...Xiangyu Wang; Huijie Zhang; Qian Zhang; Meiping Guan; Shuyue Sheng; Wei Mo; Mengchen Zou; Jimin Li; Jianlu Bi; Xianyu Tang; Huiyan Zeng; Jiali He; Gugen Xu; Ping Li; Yaoming Xue Background: Cardiovascular outcomes in clinical trials with type 2 diabetes mellitus (T2DM) patients have shown...

...Matthew R. Weir; Peter A. McCullough; John B. Buse; John Anderson Background: Chronic kidney disease (CKD) risk is elevated in patients with type 2 diabetes mellitus (T2DM). Disease management in these patients has been generally focused on glycemic control and controlling other renal and cardiac...

...Shimin Jiang; Jinying Fang; Tianyu Yu; Lin Liu; Guming Zou; Hongmei Gao; Li Zhuo; Wenge Li Background: Clinical indicators for accurately distinguishing diabetic nephropathy (DN) from non-diabetic renal disease in type 2 diabetes (T2D) are lacking. This study aimed to develop and validate...

...), heart failure (HF), and all-cause mortality (ACM) in type 2 diabetes mellitus (T2DM) patients and its importance relative to the presence of other cardio-renal-metabolic (CaReMe) comorbidities. Methods: Patients (≥40 years) were identified at the time of T2DM diagnosis from US (Humedica/Optum) and UK...

... and/or cardiovascular (CV) events among insulin-treated patients with type 2 diabetes (T2D) in routine practice is currently not known. Methods: We obtained data on a large cohort of insulin users with T2D and nephropathy (baseline ACR ≥300 mg/g) from UK general practices between 2007 and 2014. Their corresponding ACR...

... plays a key role for vascular disease progression. Recent studies have demonstrated a strong link between vitamin D and cardiovascular disease. Methods: We investigated the anti-oxidative effects of a vitamin D analog, 22-oxacalcitriol (maxacalcitol), on vascular lesions in type 2 diabetic rats. We used...

... of pro-inflammatory molecules. Methods: This exploratory multi-center, open-label study assessed the clinical activity and safety of bardoxolone methyl in 20 patients with moderate to severe chronic kidney disease and type 2 diabetes. Patients received 25 mg of bardoxolone methyl daily for 28 days...

... polymorphisms as a prognostic factor for the development of diabetic nephropathy (DN). Methods: A total of 525 type 2 diabetic patients were enrolled to participate in this prospective observational study. Apo E gene polymorphisms were analyzed by polymerase chain reaction. The progression of DN was defined...

... syndrome are associated with alterations of the renal resistive index (RI) in normoalbuminuric type 2 diabetic (T2DM) patients. Methods: A sample of 99 consecutively recruited patients with T2DM (76 male and 23 female) was examined. The RI was assessed by duplex Doppler sonography. Results: In univariate...

.... Endothelial NOS Insulin resistance BSC 1 Type 2 diabetes The obese Zucker rat is a model of gross obesity with marked insulin resistance progressing to type 2 diabetes, when rats are approximately between 4 and 6-months of age. Previously, we [ 1 ] showed a marked decrease in the renal protein...

...Nahoko Sato; Koji Komatsu; Hajimu Kurumatani Background/Aim: Prolonged exposure to hyperglycemia is one of the key factors to induce progressive diabetic nephropathy in humans. We examined whether or not the same phenomenon is observed in a nonobese type 2 diabetes model, in Goto-Kakizaki (GK) rats...

...) were found to be associated with decreased risk of the development of end-stage renal disease. This study examines whether B 1 R G –699 C and B 2 R C 181 T polymorphisms are associated with microalbuminuria or overt nephropathy, or blood pressure variation in type 2 diabetic subjects. Methods: B 1 R...