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Keywords: Tubulointerstitial fibrosis
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Journal Articles
Subject Area:
Nephrology
Am J Nephrol (2016) 43 (6): 454–459.
Published Online: 10 June 2016
...% fibrosis and 4.33 pg/mg for >10% fibrosis. After adjustment for age, sex, mGFR and 24-hour urine albumin, higher urine MCP-1 but not collagen IV associated with interstitial fibrosis and tubular atrophy. Conclusion: Urine MCP-1 may detect early tubulointerstitial fibrosis in adults with normal kidney...
Journal Articles
Subject Area:
Nephrology
Am J Nephrol (2013) 37 (3): 249–254.
Published Online: 09 March 2013
... differences in kidney biopsy complication rates between 16- and 18-gauge needles. Conclusions: Our data indicate that small biopsy needles do not provide sufficient material for diagnosis, and they increase the likelihood for a repeat biopsy. Pathology Kidney disease Tubulointerstitial fibrosis...
Journal Articles
Subject Area:
Nephrology
Am J Nephrol (2011) 34 (2): 181–194.
Published Online: 23 July 2011
.... AKF-PD Fibroblasts Tubulointerstitial fibrosis Mitogen-activated protein kinase TGF-β Smads pathway In recent years, the number of patients with end-stage renal disease (ESRD) has dramatically increased worldwide. ESRD represents the late stage of kidney disease, when residual...
Journal Articles
Subject Area:
Nephrology
Am J Nephrol (2011) 34 (2): 115–125.
Published Online: 29 June 2011
...Adam Whaley-Connell; Javad Habibi; Zachary Panfili; Melvin R. Hayden; Sarika Bagree; Ravi Nistala; Safwan Hyder; Bennett Krueger; Vincent DeMarco; Lakshmi Pulakat; Carlos M. Ferrario; Alan Parrish; James R. Sowers Background/Aims: Angiotensin (Ang) II contributes to tubulointerstitial fibrosis...
Journal Articles
Subject Area:
Nephrology
Am J Nephrol (2010) 32 (6): 590–602.
Published Online: 24 November 2010
... secretion from PTECs. Conclusions: These results suggest that HMGB-1 is a key mediator of immune-mediated EMT of PTECs and a potentially important signalling molecule in the development of renal fibrosis. Inflammation Tubulointerstitial fibrosis Transforming growth factor-β Tubulointerstitial...
Journal Articles
Subject Area:
Nephrology
Am J Nephrol (2009) 30 (5): 440–449.
Published Online: 15 September 2009
... of ischemic pretreatments with different durations on the development of tubulointerstitial fibrosis and functional impairment following acute renal I/R. Methods: We established a rat model of renal warm I/R, clamping both pedicles for 40 min followed by reperfusion; the experiment was followed up for 10...
Journal Articles
Journal Articles
Subject Area:
Nephrology
Am J Nephrol (2007) 28 (1): 34–46.
Published Online: 21 September 2007
...Zhiyin Xia; Katsushige Abe; Akira Furusu; Masanobu Miyazaki; Yoko Obata; Yasuhiko Tabata; Takehiko Koji; Shigeru Kohno Background/Aim: Unilateral ureteral obstruction (UUO) is a well-established model for tubulointerstitial fibrosis. During the progression of tubulointerstitial fibrosis...
Journal Articles
Subject Area:
Nephrology
Am J Nephrol (2007) 27 (2): 176–183.
Published Online: 07 March 2007
...) were detected by Western blot, immunoprecipitation, immunohistochemistry, and/or reverse transcription-polymerase chain reaction. Results: The results indicated progressive tubulointerstitial fibrosis, high expression levels of Arkadia, Smurf2, TβRI, TGF-β1 mRNA, type 1 collagen mRNA, and Smad7 mRNA...
Journal Articles
Subject Area:
Nephrology
Am J Nephrol (2007) 27 (2): 120–128.
Published Online: 15 February 2007
.../day), glomerulosclerosis [glomerulosclerotic index; ND: 0.26 ± 0.04; D: 1.86 ± 0.80 arbitrary units (AU)], tubulointerstitial fibrosis (tubulointerstitial fibrosis index; ND: 0.37 ± 0.05; D: 2.12 ± 0.50 AU), increased collagen type I [ND: 1.31 ± 0.07; D: 4.65 ± 0.09 relative optical density (ROD...
Journal Articles
Subject Area:
Nephrology
Am J Nephrol (2006) 26 (4): 363–371.
Published Online: 15 September 2006
...Dong Sun; Jiangmin Feng; Chun Dai; Li Sun; Tao Jin; Jianfei Ma; Lining Wang Background/Aims: To investigate the effects of peritubular capillary (PTC) loss and hypoxia on the progression of tubulointerstitial fibrosis in a rat model of aristolochic acid nephropathy (AAN). Methods: Female Wistar...
Journal Articles
Subject Area:
Nephrology
Am J Nephrol (2005) 25 (6): 611–620.
Published Online: 22 November 2005
...). The effect of pravastatin on βig-h3 expression was evaluated using in situ hybridization, immunohistochemistry, and immunoblotting. Functional parameters, histopathology (tubulointerstitial fibrosis, TIF, and arteriolopathy), and levels of transforming growth factor β1 (TGF-β1) and endothelial nitric oxide...