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Keywords: Tubulointerstitial fibrosis
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Journal Articles
Tubulointerstitial Fibrosis of Living Donor Kidneys Associates with Urinary Monocyte Chemoattractant Protein 1
Available to PurchaseSubject Area:
Nephrology
Xiangling Wang, John C. Lieske, Mariam P. Alexander, Muthuvel Jayachandran, Aleksandar Denic, Jerry Mathew, Lilach O. Lerman, Walter K. Kremers, Joseph J. Larson, Andrew D. Rule
Journal:
American Journal of Nephrology
Am J Nephrol (2016) 43 (6): 454–459.
Published Online: 10 June 2016
...% fibrosis and 4.33 pg/mg for >10% fibrosis. After adjustment for age, sex, mGFR and 24-hour urine albumin, higher urine MCP-1 but not collagen IV associated with interstitial fibrosis and tubular atrophy. Conclusion: Urine MCP-1 may detect early tubulointerstitial fibrosis in adults with normal kidney...
Journal Articles
When Size Matters: Diagnostic Value of Kidney Biopsy according to the Gauge of the Biopsy Needle
Available to PurchaseSubject Area:
Nephrology
Rachel Roth, Samir Parikh, Dayanand Makey, Jamison Foster, Grigory Rozenblit, Anjali Satoskar, Gyongyi Nadasdy, Jon Von Visger, Lee Hebert, Brad H. Rovin, Tibor Nadasdy, Sergey V. Brodsky
Journal:
American Journal of Nephrology
Am J Nephrol (2013) 37 (3): 249–254.
Published Online: 09 March 2013
... differences in kidney biopsy complication rates between 16- and 18-gauge needles. Conclusions: Our data indicate that small biopsy needles do not provide sufficient material for diagnosis, and they increase the likelihood for a repeat biopsy. Pathology Kidney disease Tubulointerstitial fibrosis...
Journal Articles
Fluorofenidone Attenuates Tubulointerstitial Fibrosis by Inhibiting TGF-β1-Induced Fibroblast Activation
Available to PurchaseSubject Area:
Nephrology
Qiongjing Yuan, Rui Wang, Yu Peng, Xiao Fu, Wei Wang, Linghao Wang, Fangfang Zhang, Zhangzhe Peng, Wangbin Ning, Gaoyun Hu, Zhaohe Wang, Lijian Tao
Journal:
American Journal of Nephrology
Am J Nephrol (2011) 34 (2): 181–194.
Published Online: 23 July 2011
.... AKF-PD Fibroblasts Tubulointerstitial fibrosis Mitogen-activated protein kinase TGF-β Smads pathway In recent years, the number of patients with end-stage renal disease (ESRD) has dramatically increased worldwide. ESRD represents the late stage of kidney disease, when residual...
Journal Articles
Angiotensin II Activation of mTOR Results in Tubulointerstitial Fibrosis through Loss of N-Cadherin
Available to PurchaseSubject Area:
Nephrology
Adam Whaley-Connell, Javad Habibi, Zachary Panfili, Melvin R. Hayden, Sarika Bagree, Ravi Nistala, Safwan Hyder, Bennett Krueger, Vincent DeMarco, Lakshmi Pulakat, Carlos M. Ferrario, Alan Parrish, James R. Sowers
Journal:
American Journal of Nephrology
Am J Nephrol (2011) 34 (2): 115–125.
Published Online: 29 June 2011
...Adam Whaley-Connell; Javad Habibi; Zachary Panfili; Melvin R. Hayden; Sarika Bagree; Ravi Nistala; Safwan Hyder; Bennett Krueger; Vincent DeMarco; Lakshmi Pulakat; Carlos M. Ferrario; Alan Parrish; James R. Sowers Background/Aims: Angiotensin (Ang) II contributes to tubulointerstitial fibrosis...
Journal Articles
High-Mobility Group Box Protein 1: A Novel Mediator of Inflammatory-Induced Renal Epithelial-Mesenchymal Transition
Available to PurchaseSubject Area:
Nephrology
Journal:
American Journal of Nephrology
Am J Nephrol (2010) 32 (6): 590–602.
Published Online: 24 November 2010
... secretion from PTECs. Conclusions: These results suggest that HMGB-1 is a key mediator of immune-mediated EMT of PTECs and a potentially important signalling molecule in the development of renal fibrosis. Inflammation Tubulointerstitial fibrosis Transforming growth factor-β Tubulointerstitial...
Journal Articles
Diverse Effects of Ischemic Pretreatments on the Long-Term Renal Damage Induced by Ischemia-Reperfusion
Available to PurchaseSubject Area:
Nephrology
Journal:
American Journal of Nephrology
Am J Nephrol (2009) 30 (5): 440–449.
Published Online: 15 September 2009
... of ischemic pretreatments with different durations on the development of tubulointerstitial fibrosis and functional impairment following acute renal I/R. Methods: We established a rat model of renal warm I/R, clamping both pedicles for 40 min followed by reperfusion; the experiment was followed up for 10...
Journal Articles
Functional and Partial Morphological Regression of Established Renal Injury in the Obese Zucker Rat by Blockade of the Renin-Angiotensin System
Available to PurchaseSubject Area:
Nephrology
Journal:
American Journal of Nephrology
Am J Nephrol (2009) 29 (3): 164–170.
Published Online: 28 August 2008
.... Tubulointerstitial fibrosis and vascular injury remain unchanged. Proteinuria shows marked regression. 25 06 2008 14 07 2008 28 8 2008 Tubulointerstitial and vascular damage indices were assessed on PAS-stained paraffin sections using the previously described scoring system [ 7, 9...
Journal Articles
Suppression of Renal Tubulointerstitial Fibrosis by Small Interfering RNA Targeting Heat Shock Protein 47
Available to PurchaseSubject Area:
Nephrology
Zhiyin Xia, Katsushige Abe, Akira Furusu, Masanobu Miyazaki, Yoko Obata, Yasuhiko Tabata, Takehiko Koji, Shigeru Kohno
Journal:
American Journal of Nephrology
Am J Nephrol (2007) 28 (1): 34–46.
Published Online: 21 September 2007
...Zhiyin Xia; Katsushige Abe; Akira Furusu; Masanobu Miyazaki; Yoko Obata; Yasuhiko Tabata; Takehiko Koji; Shigeru Kohno Background/Aim: Unilateral ureteral obstruction (UUO) is a well-established model for tubulointerstitial fibrosis. During the progression of tubulointerstitial fibrosis...
Journal Articles
Arkadia-Smad7-Mediated Positive Regulation of TGF-β Signaling in a Rat Model of Tubulointerstitial Fibrosis
Available to PurchaseSubject Area:
Nephrology
Journal:
American Journal of Nephrology
Am J Nephrol (2007) 27 (2): 176–183.
Published Online: 07 March 2007
...) were detected by Western blot, immunoprecipitation, immunohistochemistry, and/or reverse transcription-polymerase chain reaction. Results: The results indicated progressive tubulointerstitial fibrosis, high expression levels of Arkadia, Smurf2, TβRI, TGF-β1 mRNA, type 1 collagen mRNA, and Smad7 mRNA...
Journal Articles
Renoprotective Effects of a Selective Estrogen Receptor Modulator, Raloxifene, in an Animal Model of Diabetic Nephropathy
Available to PurchaseSubject Area:
Nephrology
Journal:
American Journal of Nephrology
Am J Nephrol (2007) 27 (2): 120–128.
Published Online: 15 February 2007
.../day), glomerulosclerosis [glomerulosclerotic index; ND: 0.26 ± 0.04; D: 1.86 ± 0.80 arbitrary units (AU)], tubulointerstitial fibrosis (tubulointerstitial fibrosis index; ND: 0.37 ± 0.05; D: 2.12 ± 0.50 AU), increased collagen type I [ND: 1.31 ± 0.07; D: 4.65 ± 0.09 relative optical density (ROD...
Journal Articles
Role of Peritubular Capillary Loss and Hypoxia in Progressive Tubulointerstitial Fibrosis in a Rat Model of Aristolochic Acid Nephropathy
Available to PurchaseSubject Area:
Nephrology
Journal:
American Journal of Nephrology
Am J Nephrol (2006) 26 (4): 363–371.
Published Online: 15 September 2006
...Dong Sun; Jiangmin Feng; Chun Dai; Li Sun; Tao Jin; Jianfei Ma; Lining Wang Background/Aims: To investigate the effects of peritubular capillary (PTC) loss and hypoxia on the progression of tubulointerstitial fibrosis in a rat model of aristolochic acid nephropathy (AAN). Methods: Female Wistar...
Journal Articles
Inhibitory Effect of Pravastatin on Transforming Growth Factor β1-Inducible Gene h3 Expression in a Rat Model of Chronic Cyclosporine Nephropathy
Available to PurchaseSubject Area:
Nephrology
Journal:
American Journal of Nephrology
Am J Nephrol (2005) 25 (6): 611–620.
Published Online: 22 November 2005
...). The effect of pravastatin on βig-h3 expression was evaluated using in situ hybridization, immunohistochemistry, and immunoblotting. Functional parameters, histopathology (tubulointerstitial fibrosis, TIF, and arteriolopathy), and levels of transforming growth factor β1 (TGF-β1) and endothelial nitric oxide...