...Natsuki Kushida; Seitaro Nomura; Imari Mimura; Takanori Fujita; Shogo Yamamoto; Masaomi Nangaku; Hiroyuki Aburatani Background: Kidney injury, including chronic kidney disease and acute kidney injury, is a worldwide health problem. Hypoxia and transforming growth factor-β (TGF-β) are well-known...

... in epithelial morphology consistent with EMT including reduced E-cadherin expression, increased α-smooth muscle actin expression and enhanced cell migration. HMGB-1 effects were mediated at least in part by the receptor for advanced glycation end products and through induction of transforming growth factor-β 1...

..., in parallel with stress fiber formation. This colocalization was observed even when actin filaments were depolymerized with cytochalasin D. Tpbg localization at focal adhesions was induced by dominant-active RhoA and suppressed by the ROCK1 inhibitor Y-26732. In addition, transforming growth factor-β...

... and α-SMA expression induced by CTGF but not by transforming growth factor-β 1 (TGF-β 1 ). The expressions of E-cadherin and zonula occludens-1 reduced by CTGF but not by TGF-β 1 were increased by LXA 4 . LXA 4 inhibited the expression and activity of ILK and activation of Ras, ERK1/2, PI3-K and Akt...

..., instructions or products referred to in the content or advertisements. Diabetic nephropathy Cytokines Cell signaling Transforming growth factor-β Diabetic nephropathy (DN) is the largest single cause of end-stage renal failure worldwide. Despite the available modern therapies of glycemia...

... or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Transforming growth factor-β Epithelial-to-mesenchymal transition Diabetic nephropathy Diabetic nephropathy (DN) is the single commonest cause of entry into the renal...

... weeks. Prior ischemia (10, 20, 30 min) was induced 8 days before the 40-min ischemia. To assess tissue fibrosis, we performed morphometric analysis, Masson’s trichrome and Sirius red staining. We also analyzed the expression of α-smooth muscle actin (α-SMA), transforming growth factor-β 1 (TGF-β 1...

... II Renal diseases Renin Prorenin Transforming growth factor-β © 2009 S. Karger AG, Basel 2009 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means...

... by apocynin indicates a primary role for NADPH oxidase in producing oxidative stress. Induction of transforming growth factor-β 1 and fibronectin was inhibited by antioxidants and inhibitors of PKC and AGE. Conclusions: Oxidative stress mediated cross-activation between PKC and AGE in this mesangial cell...

... responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Nephrectomy, contralateral Growth, compensatory Inflammation Transforming growth factor-β Angiotensin-II Nitric oxide Interleukin-4, 6, 10...

... Erythropoietin Fibrosis Osteopontin Transforming growth factor-β Cyclosporin A (CsA) is a potent immunosuppressant for the treatment of allograft rejection and various autoimmune disorders. However, chronic nephrotoxicity has been reported in both transplant and nontransplant settings [ 1...

..., instructions or products referred to in the content or advertisements. Focal segmental glomerulosclerosis Genetic polymorphisms Transforming growth factor-β Tumor necrosis factor-α Interleukin-6 Focal segmental glomerulosclerosis (FSGS) is currently a leading cause of nephrotic syndrome...

... adsorbent AST-120 Diabetic nephropathy Otsuka Long-Evans Tokushima Fatty rats Transforming growth factor-β Laboratory Investigation Am J Nephrol 2000;20:232 241 Received: June 3, 1999 Accepted: February 11, 2000 Oral Adsorbent AST-120 Ameliorates Interstitial Fibrosis and Transforming Growth Factor...