... dominant polycystic kidney disease (ADPKD) to identify who may experience a rapid decline of renal function. Our aim was to validate this predictive model in a population from southern Spain. Methods: ADPKD patients with measurements of height-adjusted total kidney volume (HtTKV) and baseline estimated...

... disease (ADPKD). However, the official indication of “rapidly progressive disease” is described differently in the clinical guidelines. We aim to define “rapidly progressive disease” by risk of ESRD, which is evaluated using estimated height-adjusted total kidney volume (HtTKV) growth rate. Methods...

... to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. 2018 Autosomal dominant polycystic kidney disease Chronic kidney disease Rapid progression Prediction Magnetic resonance imaging Ultrasound Gene Total kidney volume...

... attenuated disease progression [ 5,6,7,8,9,10 ]. In line with these reports, a recent multicenter randomized controlled trial showed that a vasopressin V2 receptor antagonist (V2RA) slowed the increase in total kidney volume and the decline in kidney function over a 3-year period in patients with relatively...

... ), glomerular hyperfiltration (eGFR ≥140 ml/min/1.73 m 2 ) and height-adjusted total kidney volume (htTKV) measured by MRI ≥600 ml/m. Results: Median follow-up was until 16.0 years of age. There were only 4 ESRD events during the follow-up period, all in the VEO group (p < 0.05). VEO patients were more...