...Dan Zhao; Wei Wang; Yang-yang Niu; Xi-hui Ren; Ai-jun Shen; Yong-sheng Xiang; Hong-yan Xie; Le-hao Wu; Chen Yu; Ying-ying Zhang Introduction: Renal fibrosis (RF), being the most important pathological change in the progression of CKD, is currently assessed by the evaluation of a biopsy...

...-ethylhexyl) phthalate Regulatory axis Renal fibrosis Renal inflammation Mitochondria We are commonly exposed to di(2-ethylhexyl) phthalate (DEHP), a phthalic acid ester plasticizer, in daily life. It is commonly used in various products, including food and beverage packaging, toys, and medical...

... between the expression of LRG1 in plasma and kidney and renal fibrosis and inflammation were analyzed. Tube formation assay was used to detect the angiogenesis in the human umbilical vein endothelial cell lines (HUVECs). And real-time PCR was used to detect the mRNA expression of LRG1, inflammatory...

... developed renal dysfunction and severe renal fibrosis associated with reductions of 78 and 67% in CREG expression, respectively, at both mRNA and protein levels in the kidney. Administration of reCREG improved renal function and relieved renal fibrosis. Administration of CREG also inhibited monocyte...

... of renal fibrosis in an experimental model of angiotensin II (Ang II)-dependent hypertension. Methods: Sprague Dawley rats ( n = 31) were divided into 4 experimental groups. Ang II (200 ng/kg/min, osmotic minipumps, s.c., n = 9) or Ang II + Empa (10 mg/kg/day, per os, n = 10) were administered for 2 weeks...

.... Galectin-3 Kidney disease Lectin Renal fibrosis Galectin-3, a member of the β-galactoside-binding lectin family, is a multifunctional protein with various biological functions. Recently, this lectin has been put forward as a possible biomarker of inflammation and renal fibrosis. Several studies...

... therapeutic strategy to control renal fibrosis. The human kidney proximal tubular epithelial cell line (HK-2 cells) was preserved in our laboratory [ 11 ]. HK-2 cells were cultured in Dulbecco's modified Eagle's medium/F12 (Invitrogen, Inc., Carlsbad, Calif., USA) containing 10% fetal calf serum...

... the onset of renal fibrogenesis. But the role of CD4+ T lymphocytes in renal fibrosis is controversial and its cellular mechanism needs to be further investigated. Methods: Biopsy specimens were from patients with minimal-change or IgA nephropathy. Mouse renal fibrosis was induced by unilateral ureteral...

...(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Tumor necrosis factor-α Nuclear transcription factor-ĸB Inflammation Renal fibrosis Hypertension Chronic renal failure...

... to in the content or advertisements. Hypoxia Twist Renal fibrosis Renal survival Twist, a basic helix-loop-helix transcription factor, was originally identified in Drosophila and was implicated in the dorsal-ventral patterning of the early embryo, with functions necessary for normal gastrulation...

.... In a similar context, recombinant PAI-1 stimulated TGF-β1 promoter activity to the same extent as TGF-β1 itself. Conclusion: Since TGF-β1 is well known to stimulate the PAI-1 promoter, we suggest that TGF-β1 and PAI-1 together constitute a positive feedback loop in the development of renal fibrosis in diabetes...

...Yee-Yung Ng; Yung-Ming Chen; Tun-Jun Tsai; Xiao-Ru Lan; Wu-Chang Yang; Hui Y. Lan Background/Aims: Pentoxifylline (PTX) has been shown to inhibit renal inflammation in a rat model of crescentic glomerulonephritis. The present study investigated the role of PTX in renal fibrosis in rats...

... of RhoGTPases by statins. Conclusion: This phenomenon could explain the beneficial effect of statins on EMT and on renal fibrosis prevention. 20 03 2006 21 06 2006 15 9 2006 © 2006 S. Karger AG, Basel 2006 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part...

... c-Jun N-terminal kinase Enalapril Angiotensin Renal fibrosis The five-sixths nephrectomy model is characterized by loss of renal function, proteinuria, and hypertension, as well as by histological abnormalities similar to those observed in many human kidney diseases [ 1, 2 ]. Treatment...