... fraction. Summary: The initial focus on the mechanisms of action of aldosterone was directed primarily on its role in modulating renal excretory function. In contrast, many recent studies have demonstrated a wider and expanded role for aldosterone in modulating inflammation, collagen formation, fibrosis...

...Riccardo Magistroni; Cristiana Corsi; Teresa Martí; Roser Torra Background: Autosomal dominant polycystic kidney disease (ADPKD) is the commonest inherited renal disorder; it is defined by progressive renal cyst formation and subsequent renal enlargement that leads to end-stage renal disease. Until...

...Kirk N. Campbell; James A. Tumlin Background: Focal segmental glomerulosclerosis (FSGS) is a histologic pattern of injury demonstrated by renal biopsy that can arise from a diverse range of causes and mechanisms. It has an estimated incidence of 7 per 1 million and is the most common primary...

...Sola Aoun Bahous; Maya Khairallah; Jad Al Danaf; Rim Halaby; Serge Korjian; Yazan Daaboul; Pascale Salameh; Antoine Stephan; Jacques Blacher; Michel E. Safar Background/Aims: Renal function decreases over time as a result of reduction in the number of functioning nephrons with age. In recipients...

...Danielle Camer; Xu-Feng Huang Bardoxolone methyl has been reported to cause detrimental cardiovascular events in the terminated BEACON Phase III human clinical trial via modulation of the renal endothelin pathway. However, the effects of bardoxolone methyl administration on the endothelin pathway...