... in glomerular podocytes and its involvement in the alteration of DNA methylation status, which regulates podocyte phenotypes. In this review, we summarize the roles of the DNA repair system in the kidneys and possible associations with altered kidney DNA methylation, which have been infrequently reported...

... matrix, the release of cytokines and growth factors (including transforming growth factor beta 1), and podocyte and tubular injury leading to a slowly progressive deterioration in renal function [ 3 ]. A study of functional and morphological covariates of disease severity in patients with IgA nephropathy...

...Puneet Garg Background: Podocyte biology is a developing science that promises to help improve understanding of the mechanistic nature of multiple diseases associated with proteinuria. Proteinuria in nephrotic syndrome has been linked to mechanistic dysfunctions in the renal glomerulus involving...

...Taylor W. Harvey; Jason E. Engel; Alejandro R. Chade Background: Podocytes are major components of the filtration barrier and a renal source of vascular endothelial growth factor (VEGF). Chronic renovascular disease (RVD) progressively degrades the renal function, accompanied by podocyte damage...

... to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. nephropathy progression podocytes biomarkers diabetic nephropathy glomerular disease In conclusion, the usefulness of glomerular structural parameters...

... that in cultured differentiated podocytes, angiotensin II (ANG II) induces RAGE expression via an AT2 receptor-mediated pathway. Methods: To further confirm our results in an in vivo study, AT2 receptor knockout mice (AT2 –/– ) and wild-type mice were infused with ANG II by osmotic minipumps for 14 days. Results...

... epithelial cells in diabetic glomerulopathy. Methods: Renal histology, immunostaining and Western blot for protein level, and real-time PCR for mRNA expression of KIM-1 and podocyte markers were evaluated in untreated or losartan-treated Zucker lean (Fa/+) and Zucker diabetic fatty (Fa/Fa) rats. Results...

... (AGE-BSA). The present study was undertaken to unravel the molecular mechanisms underlying AGE-BSA-mediated NRP1 suppression. Methods: Expression of NRP1 was analyzed in podocytes. The transcriptional activity of the NRP1 promoter was investigated using wild-type and mutant NRP1 promoter reporter...

... identifying podocyte apoptosis as an early step in the pathophysiological progression to proteinuria and glomerulosclerosis, we hypothesized that vitamin D protects podocytes from undergoing apoptosis. Methods: A rat model of podocyte apoptosis was created by a single intravenous injection of 100 mg·kg –1...

...Christiane Rüster; Tzvetanka Bondeva; Sybille Franke; Nobushige Tanaka; Hiroshi Yamamoto; Gunter Wolf Background: Advanced glycation end products (AGEs) play an important role in diabetic nephropathy. The receptor for AGEs, called RAGE, is present on podocytes. We investigated whether angiotensin...

... to in the content or advertisements. Hyperhomocysteinemia Glomerulus Sulfur amino acids Oxidative stress Mesangial cells Podocytes Proteinuria National Institutes of Health (NIH) 10.13039/100000002 Hcys as a thiol-containing amino acid has gained great notoriety, since elevation...