... groups, but did not differ from sham in NX+Ca rats. Experiments with nitric oxide (NO) synthase inhibition in vitro suggested that the NO-mediated component of acetylcholine response was lower in the NX and NX+Pi groups, but did not differ from sham in NX+Ca rats. In all NX groups, aortic endothelial...

...Damir Rebić; Senija Rašić; Amina Valjevac; Snežana Unčanin; Aida Hamzić-Mehmedbašić Objectives: The purpose of this study was to determine endothelin (ET)-1 and nitric oxide (NO) serum concentration levels at baseline and after 1 year of peritoneal dialysis (PD) treatment. A further aim...

... of which are the result of endothelial cell dysfunction. Endothelial cell dysfunction is characterized by decreased endothelial nitric oxide synthase (eNOS) activity. Cationic amino acid transporter-1 (CAT-1) is the specific arginine transporter for eNOS. CsA has been shown to attenuate nitric oxide...

...Isak Demirel; Ravi Vumma; Camilla Mohlin; Lovisa Svensson; Susanne Säve; Katarina Persson Background/Aims: Increased nitric oxide (NO) production or inducible form of NO synthase activity have been documented in patients suffering from urinary tract infection (UTI), but the role...

... Hypertension Proteinuria Creatinine clearance Nitric oxide Argininosuccinate synthase Argininosuccinate lyase Arginase National Institutes of Health (NIH) 10.13039/100000002 Nitric oxide (NO) deficiency develops in patients and animals with chronic and end-stage kidney disease (CKD...

... by use of ANOVA followed by Newman-Keuls’ post-test. A value of p < 0.05 was considered to be of statistical significance. On the other hand, nitric oxide (NO) exerts a protective role against renal damage in several animal models of kidney disease [ 18,19,20,21,22 ] as well as in human chronic...

... and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Genetic polymorphism Nitric oxide NOS3 gene Proteinuria Chronic kidney disease (estimated glomerular...

...) to induce renal injury. Sesame oil (1, 2 or 4 ml/kg) was given orally 24 h after the last dose of gentamicin. Control rats were treated with saline only. Renal injury, histopathological examination, histochemical staining, osteopontin expression, superoxide anion, nitric oxide, peroxynitrite radical...

... was increased (2-fold), whereas antioxidant capacity and expression of the mitochondrial enzyme manganese superoxide dismutase (cortical –40%, medullary –53%) and medullary endothelial nitric oxide synthase (–48%) were decreased in old rats. Conclusion: Age-related intrarenal activation of the RAS preceded...

...Hideki Fujii; Keiji Kono; Kentaro Nakai; Shunsuke Goto; Hirotaka Komaba; Yasuhiro Hamada; Masami Shinohara; Riko Kitazawa; Sohei Kitazawa; Masafumi Fukagawa Background: The role of nitric oxide (NO) is controversial in diabetes nephropathy progression and the mechanisms remain unknown, especially...

..., nicotine did not change RBF in C but elicited in HC, whereas renal vascular resistance was increased in C and unchanged in HC. Indeed, chronic nicotine exposure has also reduced InCl in C. Conclusion: Nicotine acted on the adrenergic system and nitric oxide counteracted this action in C, but the same may...

...Zohra Tumur; Toshimitsu Niwa Background/Aim: Cardiovascular disease is a major cause of mortality in chronic kidney disease patients. Oxidative stress and nitric oxide (NO) deficiency play an important role in vascular endothelial cell dysfunction in chronic kidney disease. To determine...

... or indirectly provoke tubulointerstitial injury, a linkage that may underlie the functional significance of proteinuria and tubulointerstitial disease. This review also highlights two products of nitrogen metabolism, ammonia and nitric oxide, in the pathogenesis of tubulointerstitial disease. 28 10 2008...

... Prostaglandins Nitric oxide Collecting duct Medullary thick ascending limb Experimental diabetes is associated with a marked decline in renal parenchymal pO 2 , noted especially in the renal medulla. Palm et al. [ 1 ], using oxygen microelectrodes, reported reduced renal oxygenation...

... received sunflower oil, the other groups were treated with CsA (25 mg/kg/day b.w. orally) or NSO (2 ml/kg orally) or CsA + NSO, respectively. Urine and serum creatinine levels, tissue superoxide dismutase, glutathione peroxidase and catalase enzyme activities, and nitric oxide and malondialdehyde levels...

... of the expression of mRNA of angiotensin-converting enzyme and endothelial nitric oxide synthase (ecNOS). Results: SBP in female DSS rats with MI and with or without OVX transiently increased at week 4 and then gradually decreased toward the end of the study. Administration of ARB reduced SBP significantly (p...

... of each group was treated for 2 weeks with rosiglitazone (5 mg/kg body weight). After sacrifice, intrarenal transforming growth factor (TGF)-β, angiotensin-II (A-II), interleukin (IL)-6, IL-10, IL-4 and nitric oxide (NO) were assessed, and histologic sections stained to assess the inflammatory cell...

...Jai Won Chang; Eun Kyoung Lee; Tae Hee Kim; Won Ki Min; Sail Chun; Ki-Up Lee; Soon Bae Kim; Jung Sik Park Background/Aim: Endothelial dysfunction due to reduced nitric oxide (NO) availability precedes the development of atherosclerosis. Asymmetric dimethylarginine (ADMA), an endogenous inhibitor...

... chelator, has been included in preservation solutions for 18 h and reduces renal I/R injury 9 days after Tx [ 6 ]. L -Arginine is a substrate for nitric oxide synthase (NOS) and reduces renal I/R injury when administered once before I/R [ 7 ]. Glucocorticoids are anti-inflammatory agents and also prevent...

...Hamid Moradi; Vincent Kwok; Nosratola D. Vaziri Background:L -arginine ( L -arg) participates in numerous biological functions including urea and nitric oxide synthesis. Sources of L -arg include dietary proteins and endogenous synthesis by argininosuccinate synthetase and argininosuccinate lyase...