...Sarah Kelddal; Bawer Jalal Tofig; Anne-Mette Hvas; Erik Lerkevang Grove; Christian Fynbo Christiansen; Henrik Birn Introduction: Nephrotic syndrome (NS) is characterized by proteinuria, hypoalbuminemia, and edema, though not all patients present with edema. This study investigates edema prevalence...

...) patients with frequently relapsing nephrotic syndrome. However, its efficacy diminishes in several patients who experience nephrotic syndrome relapsing in short durations or failing to achieve remission. We aimed to explore the efficacy and safety of obinutuzumab, a novel anti-CD20 antibody...

...Ludmilla Le Berre; Gaëlle Tilly; Paul Pilet; Sophie Brouard; Jacques Dantal Introduction: Buffalo/Mna rats spontaneously develop nephrotic syndrome (NS) which recurs after renal transplantation. The immunosuppressive drug LF15-0195 can promote regression of the initial and post-transplantation...

... in the Nephrotic Syndrome Study Network (NEPTUNE) were analyzed using generalized estimating equation regression analyses. Models were adjusted for age, sex, glomerular diagnosis, follow-up time, estimated glomerular filtration rate, urine protein/creatinine ratio, obesity, and serum phosphorous levels. Results...

... glomerulosclerosis Nephrotic syndrome Minimal change disease (MCD) and focal segmental glomerulosclerosis (FSGS) are common causes of nephrotic syndrome in adults [ 1 ]. Both MCD and FSGS are prone to relapses, with 56–76% of adult MCD patients experiencing at least one relapse [ 1, 2 ]. This necessitates...

...Jun-Liang Chen; Li Wang; Xing-Mei Yao; Ying-Jun Zang; Yi Wang; Zhi-Jun Li; David Pearce; Hao Wang Background: Previous animal experiments and small human studies suggest that urinary plasmin can activate the epithelial sodium channel (ENaC) and contribute to sodium retention in nephrotic syndrome...

...Takaya Ozeki; Takayuki Katsuno; Hiroki Hayashi; Sawako Kato; Yoshinari Yasuda; Masahiko Ando; Naotake Tsuboi; Daisuke Hagiwara; Hiroshi Arima; Shoichi Maruyama Background: In pediatric patients with steroid-sensitive nephrotic syndrome, recent trials have revealed that a 2-month, short-term steroid...

...Puneet Garg Background: Podocyte biology is a developing science that promises to help improve understanding of the mechanistic nature of multiple diseases associated with proteinuria. Proteinuria in nephrotic syndrome has been linked to mechanistic dysfunctions in the renal glomerulus involving...

... Elderly Epidemiology Renal biopsy Nephrotic syndrome The prevalence and incidence of chronic kidney disease (CKD) and end-stage kidney disease (ESKD) are steadily increasing. There are more than one million ESKD patients worldwide [ 1,2 ]. By 2030, the number of patients needing chronic...

... these patients. Idiopathic membranous nephropathy (MN) is the most common cause of the nephrotic syndrome in the adult Caucasian population [ 1,2 ]. Beck et al. [ 3 ] identified a circulating autoantibody reactive with the transmembrane glycoprotein M-type anti-phospholipase A2 receptor 1 (anti-PLA2R...

... and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Cancer Epidemiology Membranous nephropathy Nephrotic syndrome Phospholipase A 2 receptor Membranous...

...Zaid Abassi; Irit Weissman; Tony Karram; Ilia Goltsman; Aaron Hoffman; Ori S. Better; Joseph Winaver Background: The natriuretic/diuretic response to atrial natriuretic peptide (ANP), an important regulator of water and Na + balance, is markedly attenuated in nephrotic syndrome (NS). It has been...

...D.J. Sexton; M.R. Clarkson; M.J. Mazur; W.D. Plant; J.A. Eustace Background: The nephrotic syndrome is associated with an increased risk of venous and arterial thrombosis. There are little published data on the distribution, interpretation or determinants of serum D-dimer levels in patients...

...Qiong Wen; Lan-Ting Huang; Ning Luo; Yong-Tao Wang; Xiao-Yan Li; Hai-Ping Mao; Li Zhang; Xiu-Qing Dong; Xue-Qing Yu Background: Long-term outcomes for patients with adult idiopathic nephrotic syndrome correlate closely with steroid responsiveness. The aim of this prospective study was to evaluate...

... indication for biopsy (47%), followed by nephrotic syndrome (32%). Amyloidosis was the most common histological diagnosis (16.9%), followed by crescentic glomerulonephritis type 3 associated with systemic vasculitis (14.1%). When histological findings were correlated with clinical syndromes, we found...

... to healthy controls (n = 246). Results: Mean fetuin-A serum concentrations were clearly reduced in children with nephrotic syndrome (0.25 ± 0.14 g/l, p < 0.001), slightly reduced in children with large proteinuria (0.39 ± 0.15 g/l, p < 0.05), and comparable to controls in those with mild proteinuria...

... remission has been achieved. However, based on another study from our center, in which patients were treated with vigorous immunosuppressive therapy, repeat renal biopsy a year later showed class II disease in most cases [ 23 ]. Systemic lupus erythematosus Glomerulonephritis Nephrotic syndrome...

...Paolo Cravedi; Maria Chiara Sghirlanzoni; Maddalena Marasà; Alessandra Salerno; Giuseppe Remuzzi; Piero Ruggenenti Background/Aims: First-line immunosuppression with the B-cell depleting antibody rituximab reduced proteinuria and induced remission of the disease in patients with nephrotic syndrome...

...Francesco Paolo Schena Cotugno (1736-1822) was the first to describe the presence of albumin in the urine of a patient with nephrotic syndrome, though he did not place much emphasis on this discovery, which is buried in his many other observations in anatomy, physiology, medical pathology...

...Michel Olmer; Yvon Berland; Rajsingh Purgus; Gilles Schultz We assessed blood volume (BV) in 20 edematous patients with nephrotic syndrome and in 32 subjects without renal or other disease liable to induce BV variation. Two methods were chosen, one using 131 I-albumin and the other 51 Cr red blood...