... to be beneficial to ameliorate the process of liver fibrosis, we strove to investigate their therapeutic potential to prevent peritoneal fibrosis. Methods: We used the rat model of peritoneal fibrosis induced by intraperitoneal injection of methylglyoxal and in vitro mesothelial cell culture to test the effects...

... correlated with AER, whereas patients with type 2 diabetes and macroalbuminuria had an increase in urinary methylglyoxal, an AGE intermediate. These changes were independent of isotopic glomerular filtration rate levels. Serum concentrations of AGEs or soluble receptor for AGEs were not consistently...

... chromatography/mass spectrometry Glyoxal Methylglyoxal 3-Deoxyglucosone Oxoaldehyde A high incidence of cardiovascular disease (CVD) is observed not only in patients with renal failure receiving dialysis therapy, but also in patients with chronic kidney disease (CKD) before dialysis [ 1,2,3,4,5,6...

.... Methods: The model system was electrically resistant polarized renal proximal tubular epithelial cells in monolayer culture. The model proteins comprise a well-characterized AGE, methylglyoxal-modified bovine serum albumin (MGO-BSA), and unmodified BSA. Results: Renal proximal tubular cells handle MGO-BSA...

...Masaaki Nakayama; Asahi Sakai; Miwako Numata; Tatsuo Hosoya Objective: Methylglyoxal (MGO) in a heat-sterilized conventional PD solution may damage peritoneal cells directly and/or indirectly by producing advanced glycation endproducts (AGEs). This study was conducted to (a) examine the acute...