...Nagarjunachary Ragi; Kumar Sharma Background: Chronic kidney disease (CKD) presents a persistent global health challenge, characterized by complex pathophysiology and diverse progression patterns. Metabolomics has emerged as a valuable tool in unraveling the intricate molecular mechanisms driving...

... communities are investigated by sequencing of 16S rRNA genes and functional profiles predicted using Tax4Fun, and the correlation between intestinal bacteria and IMN clinical characteristics is also analyzed. Untargeted metabolomic analysis is performed to explore the relationship between colon’s microbiota...

... Introduction: Metabolomics could offer novel prognostic biomarkers and elucidate mechanisms of diabetic kidney disease (DKD) progression. Via metabolomic analysis of urine samples from 995 CRIC participants with diabetes and state-of-the-art statistical modeling, we aimed to identify metabolites prognostic...

... application of metabolomic technologies, such as nuclear magnetic resonance and mass spectroscopy, has allowed large-scale analysis of small molecules to be interrogated in a targeted or untargeted manner. Recent advances from both human and animal studies that have arisen from metabolomic analysis have...

...Eugene P. Rhee; Clary B. Clish; Julia Wenger; Jason Roy; Sammy Elmariah; Kerry A. Pierce; Kevin Bullock; Amanda H. Anderson; Robert E. Gerszten; Harold I. Feldman Background: Whereas several longitudinal metabolomics studies have been conducted in individuals with normal estimated glomerular...