... adopted from the nonsickle cell disease kidney literature (e.g., renin-angiotensin-aldosterone system inhibitors), although data on their clinical efficacy are limited to small studies with short follow-up periods. Kidney transplantation for end-stage kidney disease improves survival compared...

... in plasma, it is present in normal people’s urine. Until now, risk stratification and chronic kidney disease (CKD) diagnosis have relied on estimated glomerular filtration rate (eGFR) and urine albumin/creatinine ratio (uACR), both of which reflect glomerular function or impairment. Tubular dysfunction...

... Introduction: Metabolomics could offer novel prognostic biomarkers and elucidate mechanisms of diabetic kidney disease (DKD) progression. Via metabolomic analysis of urine samples from 995 CRIC participants with diabetes and state-of-the-art statistical modeling, we aimed to identify metabolites prognostic...

..., quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. C-X-C motif chemokine ligand Dialysis Inflammation Biomarker Kidney disease...

...Tosihki Maeda; Takumi Nishi; Shunsuke Funakoshi; Kazuhiro Tada; Masayoshi Tsuji; Atsushi Satoh; Miki Kawazoe; Chikara Yoshimura; Hisatomi Arima Introduction: Evidence using real-world data is sparse regarding the effects of oral anticoagulants (OACs) among patients with kidney disease. The aim...

.... Within the African American Study of Kidney Disease and Hypertension (AASK; n = 570) and COMBINE ( n = 133) clinical trials, we identified participants with concordant estimated and measured creatinine excretion rates to define a subset with highly accurate 24-h urine collections, to assure a reliable...

... are not known. Study Design: Post hoc analysis of a multicenter, randomized, controlled, open-label clinical trial. Setting and Participants: Hypertensive adults without diabetes who were ≥50 years of age with prior cardiovascular disease, chronic kidney disease (CKD), 10-year Framingham risk score > 15...

...Edouard R. Martin; Mark T. Smith; Bradley J. Maroni; Qing C. Zuraw; Emil M. deGoma Background: Therapeutic options for the treatment of anemia secondary to chronic kidney disease (CKD) remain limited. Vadadustat (AKB-6548) is an oral hypoxia-inducible factor prolyl-hydroxylase domain (HIF-PHD...

... and vegetables, may impact kidney disease risk. We hypothesized that lower dietary magnesium intake would be prospectively associated with more rapid kidney function decline. Methods: Among participants in the Healthy Aging in Neighborhoods of Diversity across the Life Span study with estimated glomerular...

... of chronic kidney disease. Inhibition of galectin-3 may be a promising therapeutic strategy to prevent end-stage renal disease. Complex formation between galectin-3 and glycans or glycoproteins can be modulated by changing the pH from a neutral to a more acidic environment. In comparison with Galβ1-4GlcNAc...

... in the absence of diabetic ketoacidosis or insulin-only treatment since diagnosis. Exclusion criteria included prior serum creatinine concentrations ≥2 mg/dl or physician-diagnosed kidney disease. Hypertension was based on physician diagnosis, use of anti-hypertensive medications, or a study visit blood pressure...

...Sankar D. Navaneethan; Ciaran E. Fealy; Amanda C. Scelsi; Susana Arrigain; Steven K. Malin; John P. Kirwan Background: The feasibility and benefits of lifestyle intervention in chronic kidney disease (CKD) patients who are obese has not been well studied. We examined the early effects...

... , based on observed associations, and the effect of BMI had different slopes at values greater than or less than 40 kg/m 2 . Kidney disease Serum cystatin C Creatinine Creatinine-based estimated glomerular filtration rate Cystatin C-based estimated glomerular filtration rate National...

...), APOL1 G1 and G2 nephropathy risk variants are associated with non-diabetic end-stage kidney disease (ESKD) in an autosomal recessive pattern. Additional risk and protective genetic variants may be present near the APOL1 loci, since earlier age ESKD is observed in some AAs with one APOL1 renal-risk...

...Barry I. Freedman; Susan Carrie Smith; Benjamin M. Bagwell; Jianzhao Xu; Donald W. Bowden; Jasmin Divers Background: There is a need to identify patients with diabetic kidney disease (DKD) using noninvasive, cost-effective screening tests. Sudoscan®, a device using electrochemical skin conductance...

... to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. kidney disease renal impairment cognitive aging Cognitive impairment is common in the elderly and is a major burden on the healthcare system. It is generally...

...), chronic kidney disease (rate ratio 5.0; 95% CI 2.1-11.7), and other disorders of the kidney (rate ratio 2.2; 95% CI 1.2-4.2). Conclusion: Donor subgroups at increased risk of gout include African Americans, older donors, and men. Donors with gout have a higher burden of renal complications after...

... with metabolic syndrome were obligated to receive repeated lifestyle guidance over a 6-month period after an annual health examination. Uric acid Risk factors Oxidative stress Kidney disease Epidemiology Diabetes mellitus Little is known about the clinical epidemiology of hypouricemia due...

...(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Cell biology Kidney disease Animal models TLR7 MRL/lpr mice DC Treg Toll-like receptors (TLRs) are a group...

... in mild kidney disease. These data stress the need for interventions to prevent cognitive decline well before the late stages of kidney disease. [email protected] 29 05 2014 14 08 2014 10 10 2014 © 2014 S. Karger AG, Basel 2014 Copyright / Drug Dosage / Disclaimer...