...Johanna Rehnberg; Jonas F. Ludvigsson; Louise Emilsson Introduction: IgA nephropathy is the most common primary kidney disease in the world and has a highly variable clinical presentation. While studies have indicated a link between glomerular disease and infections, large-scale studies on IgA...

...John J. Sim; Qiaoling Chen; Nancy Cannizzaro; Simran K. Bhandari; Ancilla W. Fernandes; John Chang; Cibele Pinto; Asher D. Schachter; Mohit Mathur Introduction: IgA nephropathy (IgAN), a leading cause of kidney failure worldwide, is one of the most common forms of primary glomerulonephropathy...

... excretion and progression of IgA nephropathy. Methods: We assessed 596 patients with IgA nephropathy, and urinary sodium excretion was measured at the time of kidney biopsy. Cox proportional hazards models and restricted cubic splines were used to assess the association between urinary sodium excretion...

... deposition is innocuous or contributes to organ damage. Next, although complement is known to be involved in the pathogenesis of IgA nephropathy (IgAN), its involvement has not been studied systematically in kidney transplant recipients (KTRs). Methods: KTRs with biopsy-proven native IgAN who underwent...

...Zi Wang; Xujie Zhou; Sufang Shi; Lijun Liu; Jicheng Lv; Hong Zhang Introduction: In 2016, the Oxford Classification of IgA nephropathy (IgAN) updated its scoring system for the glomerular crescents. Despite this, the clinical significance of crescentic lesions in the updated Oxford classification...

...Wenchao Li; Ruifan Chen; Wei Chen; Fengxian Huang; Xi Xia Introduction: IgA nephropathy (IgAN) with serum antineutrophil cytoplasmic autoantibody (ANCA) positivity is uncommon. This study analyzed the clinicopathologic features and prognosis of IgAN patients with serum ANCA positivity. Methods...

...Shujie Wang; Danni Hu; Yue-Qiang Li; Qing Lei; Liu Liu; Xiaofeng He; Min Han; Guangchang Pei; Rui Zeng; Gang Xu Introduction: This observational cohort study evaluated the prognostic value of mast cells in the pathogenesis and progression of IgA nephropathy. Methods: A total of 76 adult IgAN...

...Ziyuan Huang; Ji Zhang; Bo Chen; Duo Li; Xiaohan You; Yin Zhou; Wenxian Qiu; Xiaokai Ding; Chaosheng Chen Introduction: The clinical significance of persistent hematuria degrees has not been expounded in primary IgA nephropathy (IgAN) and requires further research. Methods: From January 2003 to May...

...Nirali Ramani; William L. Whittier; Stephen M. Korbet Introduction: The presence of crescents in IgA nephropathy (IgAN) has been associated with a poor prognosis. We assess the prognosis of crescents in our patients with IgAN. Methods: IgAN was diagnosed in 73 patients biopsied at Rush University...

..., USA), and uUMOD levels were normalized individually to urinary Cr levels. IgA nephropathy (IgAN) accounts for about 40% of cases of primary glomerulonephritis and is associated with hematuria and proteinuria and a gradual decline in renal function. It has a poor prognosis in that 40...

...Lu Wen; Xiaoyang Wang; Fengping Ji; Jianguo Wen; Zhanzheng Zhao Introduction: Megalin plays an important role in proximal tubule uptake of filtered proteins. Downregulation and dysfunction of megalin were previously demonstrated in IgA nephropathy (IgAN); however, its relationship to IgAN...

... or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. 2022 IgA nephropathy Interstitial inflammation Chronic kidney...

... [email protected] 25 09 2021 16 11 2021 29 12 2021 Glomerulonephritis IgA nephropathy Diagnostic biomarkers Lectins Glycomics IgA nephropathy (IgAN) is the most common form of primary glomerulonephritis worldwide, characterized by persistent microscopic...

... requiring dialysis or kidney transplantation. The Therapeutic Evaluation of STeroids in IgA Nephropathy Global (TESTING) study was designed to assess the benefits and risks of steroids in people with IgAN. We report the trial design as well as the baseline characteristics of study participants. Methods...

...Zaoqiang Lin; Lichang Liu; Rongling Zhang; Xuefei Lin; Fuhua Lu; Kun Bao; Lixin Wang; Qizhan Lin; Jianling Mai; Yanfei Cao; Haifeng Yang; Xusheng Liu; Chuan Zou Introduction: A working group on the Oxford classification of IgA nephropathy (IgAN) recently reported that crescents detected...

...: To investigate the relationship between hemoglobin levels and the progression of IgA nephropathy (IgAN). Methods: In a two-center cohort of 1,828 cases with biopsy-proven IgAN, we examined the association of hemoglobin levels with the primary outcome of a composite of all-cause mortality or kidney failure...

...Youn Kyung Kee; Bo Young Nam; Jong Hyun Jhee; Jung Tak Park; Beom Jin Lim; Tae-Hyun Yoo; Shin-Wook Kang; Hyun Joo Jeong; Seung Hyeok Han Background: Corticosteroids can be used to treat IgA nephropathy (IgAN). However, responsiveness to these drugs is highly variable and unpredictable...

...Chang Wang; Muyao Ye; Qiulan Zhao; Ming Xia; Di Liu; Liyu He; Guochun Chen; Youming Peng; Hong Liu Background: Aberrant O-glycosylation IgA1 production is a major factor in the pathogenesis of IgA nephropathy, but the underlying mechanism is still unclear. IgA1 glycosylation modification...

...Yujia Lin; Junya Jia; Yipeng Guo; Dandan He; Yaru Zhang; Fuzhen Wang; Tiekun Yan; Youxia Liu; Shan Lin Background: IgA nephropathy (IgAN) is a common chronic glomerular disease that, in most patients, slowly progresses to end-stage kidney disease. The therapy with corticosteroid in IgAN is still...

...Di Liu; Yexin Liu; Guochun Chen; Liyu He; Chengyuan Tang; Chang Wang; Danyi Yang; Huiqiong Li; Zheng Dong; Hong Liu Background: IgA nephropathy (IgAN) has been considered to be the most frequent form of primary glomerulonephritis that occurs worldwide with a variety of factors involved in its...