... or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. 2022 Anemia Erythropoietin Chronic kidney disease Hypoxia-inducible factor Iron...

... to assess the efficacy and safety of the desidustat, an oral hypoxia-inducible factor prolyl hydroxylase inhibitor, against the epoetin alfa for the treatment of anemia in patients with chronic kidney disease (CKD) with dialysis dependency. Methods: DREAM-D was a phase 3, multicenter, open-label, randomized...

... Sharma; Kuldipsinh Zala; Deven Parmar; Study Investigator Group Background: Desidustat, an oral hypoxia-inducible factor prolyl hydroxylase inhibitor, is being developed to treat anemia in patients with chronic kidney disease (CKD) without dialysis dependency. Methods: In total, 588 patients...

...Jay B. Wish Table 2. Promise and Reality of HIF-PHIs versus ESAs Fig. 1. ESAs, erythropoiesis-stimulating agents; HIF-PHIs, hypoxia-inducible factor prolyl hydroxylase inhibitors; MACE, major adverse cardiovascular events; Hb, hemoglobin; GI, gastrointestinal; ✓, demonstrated...

... mark hypoxia-inducible factor for degradation through hydroxylation. Its safety and efficacy (noninferiority) were assessed in this 52-week, open-label study. Methods: Japanese patients not on dialysis (ND) ( N = 299) with anemia of CKD (stages G3, G4, and G5) with iron parameters of ferritin >100...

...Deven V. Parmar; Kevinkumar A. Kansagra; Jatin C. Patel; Shuchi N. Joshi; Nitin S. Sharma; Apeksha D. Shelat; Nirav B. Patel; Vishal B. Nakrani; Farheen A. Shaikh; Harilal V. Patel; on behalf of the ZYAN1 Trial Investigators Background: Desidustat (ZYAN1) is an oral hypoxia-inducible factor prolyl...

... transfusions when necessary; however, safety considerations associated with these therapies highlight the need to pursue alternative treatment options targeting other mechanisms such as hypoxia-inducible factors (HIFs) that act as central regulators of erythropoiesis by coordinating a series of graded hypoxic...

...Prashant Jamadarkhana; Anita Chaudhary; Laxmikant Chhipa; Amita Dubey; Anookh Mohanan; Rameshchandra Gupta; Shailesh Deshpande Background: Hypoxia-inducible factor (HIF) transcriptional system plays a central role in cellular adaptation to low oxygen levels. Preconditional activation of HIF...

... of IR kidneys disclosed critically low medullary pO 2 (determined by pimonidazole adducts), regional hypoxic cell response (hypoxia-inducible factors) and upregulation of endothelin-B receptors. Conclusions: Compensatory changes result in normal plasma creatinine 1 and 3 months after IR, despite...

... ubiquitin-ligase complex VEC that targets the alpha subunits of hypoxia-inducible factor (HIF) for ubiquitination. Ubiquitin-tagged HIF-α proteins are subsequently degraded by the common 26S proteasome. pVHL functions as the substrate-docking interface that specifically recognizes prolyl-hydroxylated HIF-α...