...Chungang Guo; Tammy Dugas; Clinton Scates; Maria Garcia-Villarreal; Thomas Ticich; Kenneth E. McMartin Background/Aims: Renal damage from ethylene glycol and primary hyperoxaluria is linked to accumulation of calcium oxalate monohydrate (COM) crystals in the renal proximal tubule (PT). In vitro...

... hypercalciuric patients. Mean oxalate excretion was similar in normocalciuric and in hypercalciuric patients, on free-choice as well as on Ca-enriched diet. In both conditions the incidence of hyperoxaluria ( ≥ 435 μmol/24 h) within each group of stone formers was also similar, ranging from 11 to 22%. On low-Ca...

.... Lipid peroxidation Antioxidants Calcium oxalate LLC-PK 1 cells Free radicals Hyperoxaluria Transforming growth factor-β 1 NAD(P)H oxidase Lipid peroxidation is one of the major pathways in the mechanism involved in hyperoxaluria-induced urolithiasis [ 1 ]. It is also well known...

... by angiotensin II receptor activation. However, the renal and intestinal handling of oxalate has not been evaluated for other common models of hyperoxaluria that simulate primary hyperoxaluria or oxalate stone disease. Methods: We assessed the renal clearances of creatinine, oxalate and calcium in three rat...