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Sishir Gang, Prakash Khetan, Deepak Varade, Venkata Ramakrishna Chinta, Siddharth Mavani, Umesh Gupta, S. Venkata Krishna Reddy, Sunil Rajanna, Tarun Jeloka, Vivek Ruhela, Kevinkumar Kansagra, Pooja Kanani, Jayesh Bhatt, Kuldipsinh Zala, Study Investigator Group
Am J Nephrol (2022) 53 (5): 343–351.
Published Online: 22 April 2022
... Hepcidin Anemia is a common complication of chronic kidney disease (CKD) [1, 2]. It is associated with significant morbidity, mortality, progression of kidney disease in patients with diabetes, and higher transfusion rates in the CKD population [3-5]. Anemia may result from several causes...
Dhananjai Agrawal, Deepak Varade, Hardik Shah, Alm Nazar, Jayakumar Krishnan, Vineet Shukla, Chinta Ramakrishna, Mahel Chinthana Bandara Galahitiyawa, Sidhharth B. Mavani, Sunil Rajanna, Petkar Jikki, Shamila De Silva, Vivek Ruhela, Parshottam Koradia, Kevinkumar Kansagra, Pooja Kanani, Nitin Sharma, Kuldipsinh Zala, Deven Parmar, Study Investigator Group
Am J Nephrol (2022) 53 (5): 352–360.
Published Online: 22 April 2022
... for 24 weeks. The primary outcome was the change from baseline in hemoglobin to evaluation period of Weeks 16–24. Key secondary outcomes included the number of patients with hemoglobin response, changes in the hepcidin levels, changes in the vascular endothelial growth factor (VEGF) levels, and changes...
Am J Nephrol (2022) 53 (5): 333–342.
Published Online: 22 April 2022
... to in the content or advertisements. Erythropoietin Resistance Index Erythropoiesis-stimulating agents Hemodialysis Hepcidin Hypoxia-inducible factor-prolyl hydroxylase inhibitor National Institutes of Health (NIH) 10.13039/100000002 Patients on hemodialysis (HD) vary considerably...
Deven V. Parmar, Kevinkumar A. Kansagra, Jatin C. Patel, Shuchi N. Joshi, Nitin S. Sharma, Apeksha D. Shelat, Nirav B. Patel, Vishal B. Nakrani, Farheen A. Shaikh, Harilal V. Patel, on behalf of the ZYAN1 Trial Investigators
Am J Nephrol (2019) 49 (6): 470–478.
Published Online: 21 May 2019
..., instructions or products referred to in the content or advertisements. Visual Abstract Visual Abstract. Anemia in chronic kidney disease Hypoxia-inducible factor Hemoglobin Hepcidin Randomized clinical trial Anemia is a complication of chronic kidney disease (CKD...
Tadao Akizawa, Masaomi Nangaku, Takuhiro Yamaguchi, Masanobu Arai, Ryosuke Koretomo, Atsushi Matsui, Hideki Hirakata
Am J Nephrol (2019) 49 (2): 165–174.
Published Online: 30 January 2019
... in hepcidin and ferritin and increased total iron-binding capacity and was generally well tolerated. Conclusions: Enarodustat corrects and maintains Hb levels in anemic patients with CKD not on dialysis. firstname.lastname@example.org Enarodustat Anemia in chronic kidney disease Hypoxia-inducible...
Jay B. Wish, George R. Aronoff, Bruce R. Bacon, Carlo Brugnara, Kai-Uwe Eckardt, Tomas Ganz, Iain C. Macdougall, Julio Núñez, Adam J. Perahia, John C. Wood
Am J Nephrol (2018) 47 (2): 72–83.
Published Online: 13 February 2018
... no single diagnostic test can, at present, accurately assess iron status and risk for toxicity, clinicians need to take an integrative approach to avoid iron doses that impose excessive exposure while ensuring sufficient replenishment of iron stores capable of overcoming hepcidin blockade and allowing...
Am J Nephrol (2016) 43 (4): 237–244.
Published Online: 22 April 2016
..., the host's strategy of sequestering iron in cells may efficiently inhibit proliferation. However, the same strategy may favor the intracellular growth of microorganisms. The administration of excessive amounts of iron may modify iron localization by an increase in the hepcidin concentration. We conclude...
Adam Rumjon, Pantelis Sarafidis, Stephan Brincat, Rebecca Musto, Jolanta Malyszko, Sukhvinder S. Bansal, Iain C. Macdougall
Am J Nephrol (2012) 35 (3): 295–304.
Published Online: 06 March 2012
...Adam Rumjon; Pantelis Sarafidis; Stephan Brincat; Rebecca Musto; Jolanta Malyszko; Sukhvinder S. Bansal; Iain C. Macdougall Background: Hemojuvelin (HJV) has recently emerged as one of a number of significant regulators of iron homeostasis and hepcidin expression. Recently, an immunoassay has been...
Takahiro Kuragano, Yasushi Shimonaka, Aritoshi Kida, Minoru Furuta, Masayoshi Nanami, Yoshinaga Otaki, Yukiko Hasuike, Hiroshi Nonoguchi, Takeshi Nakanishi
Am J Nephrol (2010) 31 (6): 534–540.
Published Online: 14 May 2010
...Takahiro Kuragano; Yasushi Shimonaka; Aritoshi Kida; Minoru Furuta; Masayoshi Nanami; Yoshinaga Otaki; Yukiko Hasuike; Hiroshi Nonoguchi; Takeshi Nakanishi Background/Aim: Hepcidin could be one of the most important regulators for iron metabolism in patients on maintenance hemodialysis (MHD...
Am J Nephrol (2009) 30 (5): 450–458.
Published Online: 24 September 2009
... is transient and includes increased albumin excretion. There were no alterations in chemokine excretion. Altered hepcidin excretion was identified, most likely reflecting local production and renal retention. Conclusion: Proteomic analysis of mouse urine remains challenging due to the abundance of a limited...
Elísio Costa, Brian J.G. Pereira, Petronila Rocha-Pereira, Susana Rocha, Flávio Reis, Elisabeth Castro, Frederico Teixeira, Vasco Miranda, Maria do Sameiro Faria, Alfredo Loureiro, Alexandre Quintanilha, Luís Belo, Alice Santos-Silva
Am J Nephrol (2008) 28 (4): 677–683.
Published Online: 20 March 2008
.... Erythropoietin Hepcidin Iron Iron metabolism Prohepcidin Resistance rhEPO Despite significant advances in dialysis technology and the development of innovative therapies to prevent or attenuate the complications of hemodialysis (HD), mortality and morbidity of patients on dialysis remain high...
Luca Valenti, Giovanni Valenti, Giovanna Como, Gennaro Santorelli, Paola Dongiovanni, Raffaela Rametta, Anna Ludovica Fracanzani, Dario Tavazzi, Pier Giorgio Messa, Silvia Fargion
Am J Nephrol (2008) 28 (2): 311–316.
Published Online: 16 November 2007
... or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Chronic dialysis Erythropoietin Genetics Hepcidin HFE protein...
Am J Nephrol (2005) 25 (6): 586–590.
Published Online: 25 October 2005
...Jolanta Małyszko; Jacek S. Małyszko; Tomasz Hryszko; Krystyna Pawlak; Michał Mysliwiec Background: Hepcidin synthesis in hepatocytes is modulated in response to anemia, hypoxia or inflammation. A cross-sectional study was performed to assess hepcidin correlations with markers of iron status...