... Hepcidin Anemia is a common complication of chronic kidney disease (CKD) [1, 2]. It is associated with significant morbidity, mortality, progression of kidney disease in patients with diabetes, and higher transfusion rates in the CKD population [3-5]. Anemia may result from several causes...

... for 24 weeks. The primary outcome was the change from baseline in hemoglobin to evaluation period of Weeks 16–24. Key secondary outcomes included the number of patients with hemoglobin response, changes in the hepcidin levels, changes in the vascular endothelial growth factor (VEGF) levels, and changes...

... to in the content or advertisements. Erythropoietin Resistance Index Erythropoiesis-stimulating agents Hemodialysis Hepcidin Hypoxia-inducible factor-prolyl hydroxylase inhibitor National Institutes of Health (NIH) 10.13039/100000002 Patients on hemodialysis (HD) vary considerably...

..., instructions or products referred to in the content or advertisements. Visual Abstract Visual Abstract. Anemia in chronic kidney disease Hypoxia-inducible factor Hemoglobin Hepcidin Randomized clinical trial Anemia is a complication of chronic kidney disease (CKD...

... in hepcidin and ferritin and increased total iron-binding capacity and was generally well tolerated. Conclusions: Enarodustat corrects and maintains Hb levels in anemic patients with CKD not on dialysis. [email protected] 27 11 2018 28 12 2018 30 1 2019 © 2019 The Author(s...

... no single diagnostic test can, at present, accurately assess iron status and risk for toxicity, clinicians need to take an integrative approach to avoid iron doses that impose excessive exposure while ensuring sufficient replenishment of iron stores capable of overcoming hepcidin blockade and allowing...

..., the host's strategy of sequestering iron in cells may efficiently inhibit proliferation. However, the same strategy may favor the intracellular growth of microorganisms. The administration of excessive amounts of iron may modify iron localization by an increase in the hepcidin concentration. We conclude...

...Adam Rumjon; Pantelis Sarafidis; Stephan Brincat; Rebecca Musto; Jolanta Malyszko; Sukhvinder S. Bansal; Iain C. Macdougall Background: Hemojuvelin (HJV) has recently emerged as one of a number of significant regulators of iron homeostasis and hepcidin expression. Recently, an immunoassay has been...

...Takahiro Kuragano; Yasushi Shimonaka; Aritoshi Kida; Minoru Furuta; Masayoshi Nanami; Yoshinaga Otaki; Yukiko Hasuike; Hiroshi Nonoguchi; Takeshi Nakanishi Background/Aim: Hepcidin could be one of the most important regulators for iron metabolism in patients on maintenance hemodialysis (MHD...

... is transient and includes increased albumin excretion. There were no alterations in chemokine excretion. Altered hepcidin excretion was identified, most likely reflecting local production and renal retention. Conclusion: Proteomic analysis of mouse urine remains challenging due to the abundance of a limited...

.... Erythropoietin Hepcidin Iron Iron metabolism Prohepcidin Resistance rhEPO Despite significant advances in dialysis technology and the development of innovative therapies to prevent or attenuate the complications of hemodialysis (HD), mortality and morbidity of patients on dialysis remain high...

... or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Chronic dialysis Erythropoietin Genetics Hepcidin HFE protein...

...Jolanta Małyszko; Jacek S. Małyszko; Tomasz Hryszko; Krystyna Pawlak; Michał Mysliwiec Background: Hepcidin synthesis in hepatocytes is modulated in response to anemia, hypoxia or inflammation. A cross-sectional study was performed to assess hepcidin correlations with markers of iron status...