...Yuxin Lin; Yixuan Pan; Quan Han; Jianhang Xu; Junni Wang; Xin Lei; Liangliang Chen; Yaomin Wang; Pingping Ren; Lan Lan; Jianghua Chen; Fei Han Introduction: Rituximab has proven effective and safe in pediatric and adult minimal change disease (MCD) and focal segmental glomerulosclerosis (FSGS...

... syndrome (FR/SDNS). We aimed to analyze the efficacy and safety of rituximab in adult FR/SDNS patients with minimal change disease (MCD) and focal segmental glomerulosclerosis (FSGS). Methods: A retrospective cohort study at three nephrology centers in China included adult FR/SDNS patients with biopsy...

... graft survival. TG coexisting with focal segmental glomerulosclerosis (FSGS) can be found in renal allograft biopsies, but few related studies are available. Methods: Consecutive kidney transplant recipients with biopsy-proven TG were studied retrospectively. Patients concomitant with FSGS were...

... of cellular senescence is involved in impaired renal repair and progression of glomerular diseases. Focal segmental glomerulosclerosis (FSGS) is a glomerular disease with a substantial risk for progression to ESRD. However, if and to what extent cell senescence predicts a negative outcome in FSGS is still...

.... Visual Abstract Visual Abstract. African American Apolipoprotein L1 gene Chronic kidney disease Focal segmental glomerulosclerosis Interstitial pH Mitochondria National Institutes of Health (NIH) 10.13039/100000002 Approximately 13% of African Americans carry 2 copies...

...Jun Tong; Yuanmeng Jin; Qinjie Weng; Shuwen Yu; Hafiz Muhammad Jafar Hussain; Hong Ren; Jing Xu; Wen Zhang; Xiao Li; Weiming Wang; Jingyuan Xie; Nan Chen Background: Patients with focal segmental glomerulosclerosis (FSGS) characterized by steroid-resistant nephrotic syndrome (SRNS) are prone...

... mechanism remains unknown. Methods: A patient with steroid-dependent focal segmental glomerulosclerosis (FSGS) developed severe steroid side effects impacting quality of life and was converted to repository porcine ACTH therapy. Immediate response in the form of remission of nephrotic syndrome was noted...

...Dario Roccatello; Savino Sciascia; Daniela Rossi; Mirella Alpa; Carla Naretto; Massimo Radin; Antonella Barreca; Roberta Fenoglio; Simone Baldovino; Elisa Menegatti Background: A beneficial effect of rituximab (RTX) on focal segmental glomerulosclerosis (FSGS) in pediatric patients or in transplant...

... was to investigate possible correlations between urinary cells' phenotype and the progression of focal segmental glomerulosclerosis (FSGS). Methods: Forty patients with newly diagnosed FSGS were included. Cells were isolated from urine by adherence to collagen-coated cover slips and assessed for the expression...

...Andreas Kronbichler; Julia Kerschbaum; Gema Fernandez-Fresnedo; Elion Hoxha; Christine E. Kurschat; Martin Busch; Annette Bruchfeld; Gert Mayer; Michael Rudnicki Background: Minimal change disease (MCD) and focal segmental glomerulosclerosis (FSGS) remain a therapeutic challenge, since steroids...

...Yohei Ikezumi; Toshiaki Suzuki; Tamaki Karasawa; Takeshi Yamada; Hiroya Hasegawa; Hiroko Nishimura; Makoto Uchiyama Background: Recent reports suggest that low birthweight (LBW) is a risk factor for kidney diseases, including focal segmental glomerulosclerosis (FSGS), although the underlying...

...Hong Ren; Pingyan Shen; Xiao Li; Xiaoxia Pan; Wen Zhang; Nan Chen Background: The efficacy and safety of tacrolimus (TAC) and cyclophosphamide (CTX) were prospectively examined in steroid-dependent or steroid-resistant primary focal segmental glomerulosclerosis (FSGS). Methods: Patients with biopsy...

... component to this risk. Rare mutations in ACTN4 (α-actinin-4), an actin-binding protein expressed in podocytes, cause familial focal segmental glomerulosclerosis. Methods: We assessed the contribution of coding variants in ACTN4 to non-DM ESRD risk in AAs. Nineteen exons, 2,800 bases of the promoter and 392...

... and require further immunosuppression [ 1 ]. First-line therapies for diseases such as idiopathic membranous nephropathy (MN) and focal segmental glomerulosclerosis (FSGS) produce substantially lower initial response rates and are marked by similarly high relapse rates [ 2,3,4,5 ]. Thus, physicians who treat...

... were more likely to be African American (p = 0.031), followed for fewer days (p = 0.007) and have diabetes and focal segmental glomerulosclerosis on biopsy (p < 0.001). Longitudinal follow-up of CKD progression using multiple creatinine measures analyzed by repeated measures ANCOVA demonstrated...

... to histologicaíly proven membranous and membranoproliferative glomerulonephritis and focal segmental glomerulosclerosis. Half of the patients treated with perindopril displayed a decrease in urinary protein excretion from 6.1 ± 1.0 to 1.2 ± 0.5 g/24 h, and a rise in serum albumin levels. In the placebo group...

... from any ideas, methods, instructions or products referred to in the content or advertisements. Glomerulonephritis Immunosuppression Corticosteroids Alkylating agents Minimal change disease Focal segmental glomerulosclerosis Membranous nephropathy Mesangiocapillary nephritis IgA...

... was noted. There was a positive correlation between the severity of glomerular changes and prognosis among the 10 cases with minimal change disease (MCD) and the 23 with focal segmental glomerulosclerosis (FSGS). On long-term follow-up (mean over 11 years) chronic renal failure developed in none of 10 MCD...

...Regina R. Verani; Edith P. Hawkins We describe the early lesion of focal segmental glomerulosclerosis (FSGS) as it appeared in 2 cases of recurrent FSGS with early transplant nephrectomies (approximately 2 months) due to uncontrollable nephrotic syndrome. A quantitative evaluation showed...

.... CD2-associated protein Transcriptional activity CD2-associated protein promoter Sp1 transcription factor Sp3 transcription factor Nephrotic syndrome Focal segmental glomerulosclerosis End-stage renal disease is a serious public health problem and its common characterization...