.... Kidney protection Kidney function decline Glomerular filtration rate Diabetic nephropathy Type 2 diabetes mellitus Clinical trial Sodium-glucose cotransporter 2 inhibitor Sodium-glucose cotransporter 2 (SGLT2) inhibitors induce a transient natriuresis leading to a characteristic “dip...

... autologous cell therapy Neo-kidney augment Chronic kidney disease Diabetic nephropathy Diabetes-associated chronic kidney disease Renal outcomes Cell therapies attempt to address unserved clinical expectations and needs of patients and medical professionals for various chronic medical conditions...

... treatment on changes in longitudinal KidneyIntelX risk scores over time; and (4) to determine the added value of early longitudinal changes in KidneyIntelX for forecasting subsequent kidney outcomes (i.e., progressive DKD). Biomarkers Diabetic nephropathy Prognosis Response to therapy...

... course of diabetic nephropathy. In this study, we assessed the association of different patterns of atypical features, or KB indications, with NDHKD. Methods: Native KBs performed in patients with T2D were analyzed. Data were collected from the patients’ records. KB indications were determined according...

... (HD). Methods: Twenty-three male ESRD patients (age <65 years) with either chronic glomerulonephritis (CGN) or diabetic nephropathy (DN), who were enrolled between June 2019 and August 2019, were included in the study. The free thyroxine (fT 4 ), free tri-iodothyronine (fT 3 ), and thyroid...

...Shimin Jiang; Jinying Fang; Tianyu Yu; Lin Liu; Guming Zou; Hongmei Gao; Li Zhuo; Wenge Li Background: Clinical indicators for accurately distinguishing diabetic nephropathy (DN) from non-diabetic renal disease in type 2 diabetes (T2D) are lacking. This study aimed to develop and validate...

.... Albuminuria diabetes mellitus Diabetic nephropathy Diabetic kidney disease Kidney biopsy Chronic kidney disease (CKD) is a public health problem worldwide and represents one of the main causes of cardiovascular mortality [ 1 ]. Diabetic kidney disease (DKD), which develops in approximately 10–30...

... advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Diabetic nephropathy Long-term mortality...

... to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Diabetic nephropathy Renal outcomes Canagliflozin Chronic kidney disease It is estimated that around the world there are currently more than 3 million people...

... ]. Diabetes mellitus (DM) is becoming increasingly prevalent worldwide, with type 2 DM being the more predominant form in diabetic patients. Approximately 20-40% of patients with DM ultimately develop diabetic nephropathy (DN), which is the most common cause of chronic kidney disease [ 1,2,3,4 ]. However...

... samples from diabetic kidney disease (DKD) patients. Diabetic nephropathy Urinary exosomes Gelatinase Ceruloplasmin Histochemistry Fifty to 100 milliliters of fresh urine sample was centrifuged at 1,000 g for 15 min at 4°C to remove cell debris. One aliquot of the resulting supernatant...

... between diabetic nephropathy (DN) and renal outcome being increasingly clear, we aimed at creating a new DN pathological scoring system that could predict the renal outcome. Methods: We studied 205 patients with DN confirmed by renal biopsy, sometime between March 1985 and January 2010, who met...

... to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. nephropathy progression podocytes biomarkers diabetic nephropathy glomerular disease In conclusion, the usefulness of glomerular structural parameters...

...Punithavathi Ranganathan; Riyaz Mohamed; Calpurnia Jayakumar; Michael W. Brands; Ganesan Ramesh Background: Guidance cue netrin-1 was shown to have protective effects in diabetic nephropathy. However, the role of its receptor UNC5B in diabetic kidney disease is unknown. Moreover, whether netrin-1...

... albuminuria in patients having heart failure with reduced ejection fraction and mild-to-moderate (stage 2-3) chronic kidney disease. The MinerAlocorticoid Receptor Antagonist Tolerability Study-Diabetic Nephropathy (ARTS-DN; NCT01874431) is a multicenter, randomized, double-blind, placebo-controlled, parallel...

... in this gene is associated with diabetic nephropathy (DN), but the data appear to be inconsistent. Up to now, there is no biological evidence concerning the effects of SLC12A3 in DN. In this study, we aim to evaluate the genetic effects of the SLC12A3 gene and its Arg913Gln polymorphism with genetic...

... glomerulosclerosis. Further clarification of the pathways involved may prove useful for the therapy of diabetic nephropathy. New directions for investigation are discussed. The vasoactive effects of Ang II may stimulate GLUT1 synthesis [ 29 ]. In this regard, an increase in GLUT1 expression has been observed...

...G. Castoldi; C.R.T. di Gioia; C. Bombardi; C. Preziuso; M. Leopizzi; S. Maestroni; B. Corradi; G. Zerbini; A. Stella Background and Aim: Diabetic nephropathy is the main cause of end-stage renal disease. N-acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP), a physiological tetrapeptide hydrolyzed...

...Ju-Young Moon; Kyung-Hwan Jeong; Tae-Won Lee; Chun-Gyoo Ihm; Sung Jig Lim; Sang-Ho Lee Background/Aims: Recent evidence has shown that an inflammatory process is involved in the development and progression of diabetic nephropathy. This study examined the impact of activated intrarenal lymphocytes...

...Yu-Qiang Chen; Xiao-Xia Wang; Xing-Mei Yao; Dong-Liang Zhang; Xu-Feng Yang; Shou-Fu Tian; Nian-Song Wang Background: The apoptosis of podocytes is a characteristic event in diabetic nephropathy. The aim of this study was to investigate whether microRNAs (miRNAs) affect podocyte apoptosis...