...Bróna M. Moloney; Glenn Matthew Chertow; Finnian R. Mc Causland Introduction: Diabetes mellitus is a common cause of kidney failure and is often complicated by autonomic neuropathy, which may have implications for blood pressure (BP) homeostasis during hemodialysis (HD). Methods: In this post hoc...

... Introduction: Metabolomics could offer novel prognostic biomarkers and elucidate mechanisms of diabetic kidney disease (DKD) progression. Via metabolomic analysis of urine samples from 995 CRIC participants with diabetes and state-of-the-art statistical modeling, we aimed to identify metabolites prognostic...

... finerenone or SGLT2 inhibitors or their individual effects on the diabetic kidney. The most important finding in the present study is that combining SGLT-2 inhibition and finerenone has an additive positive effect on kidney function, proteinuria, and renal histology. The authors also used a robust rat model...

...Milton Packer The 2 most common causes of chronic kidney disease worldwide (type 2 diabetes and obesity) are states of nutrient excess, suggesting that fuel overabundance leads to deleterious effects on the structure and function of the kidneys. Three pathophysiological pathways may potentially...

...Luis M. Ruilope; Rajiv Agarwal; Stefan D. Anker; George L. Bakris; Gerasimos Filippatos; Christina Nowack; Peter Kolkhof; Amer Joseph; Nicole Mentenich; Bertram Pitt; FIGARO-DKD study investigators Background: Among people with diabetes, those with kidney disease have exceptionally high rates...

...George L. Bakris; Rajiv Agarwal; Stefan D. Anker; Bertram Pitt; Luis M. Ruilope; Christina Nowack; Peter Kolkhof; Anna C. Ferreira; Patrick Schloemer; Gerasimos Filippatos; on behalf of the FIDELIO-DKD study investigators Background: Among diabetics, those with kidney disease have exceptionally...

... results in the development of fibrosis, a hallmark of progressive CKD. To evaluate the role of functional magnetic resonance imaging (MRI), we performed perfusion, oxygenation, and diffusion MRI measurements in individuals with diabetes and stage 3 CKD. Methods: Fifty-four subjects (41 individuals...

... locations in each of 4 states. People with diabetes, hypertension, or aged ≥50 years were eligible to participate. In addition to CKD, screening included testing and measures of hemoglobin A1C, blood pressure, and lipids. - Results: In this targeted population, among 894 people screened, CKD prevalence...

... individuals with diabetic kidney disease (DKD), chronic kidney disease, type 2 diabetes (T2DM), and obese and healthy controls to determine if such biomarkers had the potential to classify kidney disease and predict patients at higher risk of renal function decline. Methods: A total of 242 participants...

...Susanne Triebswetter; Lena J. Gutjahr-Lengsfeld; Kay-Renke Schmidt; Christiane Drechsler; Christoph Wanner; Vera Krane Background: Data concerning long-term mortality predictors among large, purely diabetic hemodialysis collectives are scarce. Methods: We used data from a multicenter, prospective...

... to be causing the pathologic changes that are associated with diabetic kidney disease (DKD). Higher serum SAA concentrations were previously associated with increased risk of end-stage renal disease (ESRD) and death in persons with type 2 diabetes and advanced DKD. We explored the prognostic value of SAA...

...), and/or diabetes mellitus (DM) is largely unknown. Methods: We reviewed electronic medical record data from a geographically diverse population ( n = 911,698) receiving medical care, determined the distribution of serum potassium, and the relationship between an index potassium value and mortality over an 18-month...

... to in the content or advertisements. Immunity End-stage renal disease Diabetes Inflammation Dialysis Despite the fact that end-stage renal disease (ESRD) is stable in its incidence, suggesting some efficacy of preventive approaches (ERA/EDA Registry: www.era-edta-reg.org ), ESRD remains...

... etiology and whether they were associated with mortality. Methods: Prospective observational study of 1,157 patients, 663 with diabetic kidney disease (DKD), 273 with glomerulonephritis (GN), and 221 with cystic/interstitial disease (polycystic kidney disease, pyelonephritis or chronic tubulointerstitial...

...Zhi Su; Deborah Widomski; Ji Ma; Marian Namovic; Arthur Nikkel; Laura Leys; Lauren Olson; Katherine Salte; Diana Donnelly-Roberts; Timothy Esbenshade; Steve McGaraughty Background: Obese ZSF-1 rats display many features of human type II diabetes including nephropathy (DN). The study aimed...

... disease. In patients with diabetes with atypical features, renal biopsy may be fundamental to diagnose an unexpected parenchymal disease mislabeled as diabetic nephropathy. Finally, in elderly patients, the indications and the risks are not different from those in the general population. Key Message...

... hyperkalemia risk, but their contribution is not fully elucidated. This study aimed to compare the prevalence of hyperkalemia in diabetic and non-diabetic patients with CKD. Methods: This is a nested case-control study of 180 type-2 diabetic and 180 non-diabetic patients with CKD followed in a Nephrology...

... nucleotide polymorphisms (SNPs) were tested for association with type 2 diabetes (T2D)-associated end-stage kidney disease (ESKD) in African Americans (AAs) and European Americans (EAs), and AAs with non-diabetic ESKD. RTN1 SNPs that were associated with T2D-ESKD in AA cases compared to non-nephropathy...

...Nadine Alexander; Kunihiro Matsushita; Yingying Sang; Shoshana Ballew; Bakhtawar K. Mahmoodi; Brad C. Astor; Josef Coresh Background: Whether the association of chronic kidney disease (CKD) with cardiovascular risk differs based on diabetes mellitus (DM) and hypertension (HTN) status remains...

... clearance of metformin in patients with reduced renal function, but sufficient evidence connecting metformin concentration levels to risk of lactic acidosis is lacking [ 12,22 ]. Vasisht et al. [ 6 ] examined metformin use in 2104 patients with type 2 diabetes and CKD. In accordance with our results...