... as oxidative metabolism capacity was measured with flow cytometry in 108 CKD patients and healthy controls. Soluble markers of inflammation, such as cytokines, were analyzed using the Milliplex technique. Results: Patients showed significantly lower CD11b expression after stimulation during the 3rd (p = 0.002...

... classified as CRS1. In vitro, cell viability, DNA fragmentation and caspase-3 levels were investigated in TECs incubated with HF, CRS1, and CTR plasma. We assessed inflammatory cytokines and NGAL expression at the gene and protein levels. Results: We observed a marked pro-apoptotic activity...

... previous CV events or were on any medications except vitamins. Plasma from 95 RTR and 48 normal non-smoker controls were frozen at -80°C until time of immunoassay (Luminex®) measurement. A magnetic bead-based multiplex kit [(Bio-Plex Pro Human Cytokine panel 11 - Plex, Cat # HCP2MAG-62K-PX23...

.... Increased oxidative stress is known to be related to several pathological processes. In this study, we assessed oxidative damage in the early follow-up period after kidney transplantation measuring DNA oxidation and fragmentation of mononuclear cells and the circulating levels of inflammatory cytokines...

...Yonghong Shi; Chunyang Du; Yanling Zhang; Yunzhuo Ren; Jun Hao; Song Zhao; Fang Yao; Huijun Duan Background: Janus kinase (JAK)/signal transducers and activators of transcription (STAT) contribute to diabetic nephropathy. Suppressor of cytokine signaling-1 (SOCS-1) is one of the negative feedback...

... matrix, respond to and release a number of cytokines and vasoactive mediators. Cultured mesangial cells express receptors for circulating and local agents that affect glomerular function. These receptors are coupled to distinct signaling pathways, namely phospholipase C and A 2 , transducing...

... glomerular cells including mesangial, endothelial and epithelial cells, reactive oxygen metabolites, eicosanoids, proteolytic enzymes and a host of cytokines. Following initiation of immune glomerular injury with primary mediators, which in most cases is antibody, a complex set of interactions involving some...

...Roberto Patarca; Guido Perez; Anthony Gonzalez; Rolando 0. Garcia-Morales; Roberto Gamble; Nancy Klimas; Mary Ann Fletcher We have investigated the acute changes in cytokine gene expression patterns and immune status in vivo and ex vivo in a patient on chronic hemodialysis with cuprophane membranes...

... the majority of mechanisms of beta cell destruction remain unclear, many molecules, including proinflammatory cytokines and chemokines such as tumor necrosis factor alpha and monocyte chemoattractant protein-1, are implicated in the development of beta cell damage. Furthermore, beta cell destruction...

... in 13 hypertriglyceridemic – and hypercholesterolemic – HD patients. Conclusion: Production of soluble components of a crucial pro-inflammatory and potentially atherogenic cytokine, namely the IL-6, by stimulated PBMCs appears to be inversely correlated with the serum cholesterol levels in HD patients...

...Ute Hoffmann; Michael Fischereder; Manfred Marx; Frank Schweda; Bernhard Lang; Rainer H. Straub; Bernhard K. Krämer Background/Aims: The aim of this study was to examine the effects of a biocompatible and a nonbiocompatible hemodialysis membrane on the secretion of cytokines and their specific...

... Erythropoietin Cytokines PTH Hemodialysis Peritoneal dialysis Clinical Study Am J Nephrol 2000;20:180 186 Received: October 25, 1999 Accepted: February 14, 2000 Leptin and Serum Erythropoietin in Hemodialyzed and Peritoneally Dialyzed Uremic Patients during rHuEPO Therapy Jolanta Ma yszkoa Edyta Zbrocha S...