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1-4 of 4
Keywords: Bardoxolone methyl
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Journal Articles
Subject Area:
Nephrology
Melanie P. Chin, George L. Bakris, Geoffrey A. Block, Glenn M. Chertow, Angie Goldsberry, Lesley A. Inker, Hiddo J.L. Heerspink, Megan O’Grady, Pablo E. Pergola, Christoph Wanner, David G. Warnock, Colin J. Meyer
Journal:
American Journal of Nephrology
Am J Nephrol (2018) 47 (1): 40–47.
Published Online: 18 January 2018
..., and estimated glomerular filtration rate (eGFR) have been observed with bardoxolone methyl in 7 studies enrolling approximately 2,600 patients with type 2 diabetes (T2D) and chronic kidney disease (CKD). The largest of these studies was Bardoxolone Methyl Evaluation in Patients with Chronic Kidney Disease...
Journal Articles
The Endothelin Pathway: A Protective or Detrimental Target of Bardoxolone Methyl on Cardiac Function in Patients with Advanced Chronic Kidney Disease?
Available to PurchaseSubject Area:
Nephrology
Journal:
American Journal of Nephrology
Am J Nephrol (2014) 40 (3): 288–290.
Published Online: 15 October 2014
...Danielle Camer; Xu-Feng Huang Bardoxolone methyl has been reported to cause detrimental cardiovascular events in the terminated BEACON Phase III human clinical trial via modulation of the renal endothelin pathway. However, the effects of bardoxolone methyl administration on the endothelin pathway...
Journal Articles
Melanie P. Chin, Scott A. Reisman, George L. Bakris, Megan O'Grady, Peter G. Linde, Peter A. McCullough, David Packham, Nosratola D. Vaziri, Keith W. Ward, David G. Warnock, Colin J. Meyer
Journal:
American Journal of Nephrology
Am J Nephrol (2014) 39 (6): 499–508.
Published Online: 03 June 2014
...Melanie P. Chin; Scott A. Reisman; George L. Bakris; Megan O'Grady; Peter G. Linde; Peter A. McCullough; David Packham; Nosratola D. Vaziri; Keith W. Ward; David G. Warnock; Colin J. Meyer Background: Bardoxolone methyl, an Nrf2-activating and nuclear factor-κB-inhibiting semisynthetic oleanane...
Journal Articles
Rationale and Trial Design of Bardoxolone Methyl Evaluation in Patients with Chronic Kidney Disease and Type 2 Diabetes: The Occurrence of Renal Events (BEACON)
Available to PurchaseDick de Zeeuw, Tadao Akizawa, Rajiv Agarwal, Paul Audhya, George L. Bakris, Melanie Chin, Melissa Krauth, Hiddo J. Lambers Heerspink, Colin J. Meyer, John J. McMurray, Hans-Henrik Parving, Pablo E. Pergola, Giuseppe Remuzzi, Robert D. Toto, Nosratola D. Vaziri, Christoph Wanner, David G. Warnock, Janet Wittes, Glenn M. Chertow
Journal:
American Journal of Nephrology
Am J Nephrol (2013) 37 (3): 212–222.
Published Online: 28 February 2013
... (RAAS). Bardoxolone methyl, a synthetic triterpenoid that reduces oxidative stress and inflammation through Nrf2 activation and inhibition of NF-κB was previously shown to increase estimated glomerular filtration rate (eGFR) in patients with CKD associated with type 2 diabetes mellitus. To date...
