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Journal Articles

Perceptions regarding Genetic Testing in Populations at Risk for Nephropathy

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Subject Area:
Nephrology
Barry I. Freedman, Alison J. Fletcher, Vivek R. Sanghani, Mitzie Spainhour, Angelina W. Graham, Gregory B. Russell, Jessica N. Cooke Bailey, Ana S. Iltis, Nancy M.P. King
Journal: American Journal of Nephrology
Am J Nephrol (2014) 38 (6): 453–457.
https://doi.org/10.1159/000356244
Published Online: 21 November 2013
... regarding returning genetic test results to participants. African-Americans (AAs) and European-Americans (EAs) at risk for end-stage kidney disease were queried for views on the value and use of genetic testing in research. Methods: A standardized survey regarding attitudes toward genetic testing...
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Journal Articles

Relevance of the ACTN4 Gene in African-Americans with Non-Diabetic End-Stage Renal Disease

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Subject Area:
Topic Article Package: Diabetes , Nephrology
Meredith A. Bostrom, Peter Perlegas, Lingyi Lu, Pamela J. Hicks, Greg Hawkins, Maggie C.Y. Ng, Carl D. Langefeld, Barry I. Freedman, Donald W. Bowden
Journal: American Journal of Nephrology
Am J Nephrol (2012) 36 (3): 252–260.
https://doi.org/10.1159/000342205
Published Online: 03 September 2012
...Meredith A. Bostrom; Peter Perlegas; Lingyi Lu; Pamela J. Hicks; Greg Hawkins; Maggie C.Y. Ng; Carl D. Langefeld; Barry I. Freedman; Donald W. Bowden Background: African-Americans (AAs) are predisposed to non-diabetic (non-DM) end-stage renal disease (ESRD), and studies have shown a genetic...
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Journal Articles

Distribution of Volumes of Individual Glomeruli in Kidneys at Autopsy: Association with Physical and Clinical Characteristics and with Ethnic Group

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Subject Area:
Nephrology
Wendy E. Hoy, Michael D. Hughson, Boucar Diouf, Monika Zimanyi, Terence Samuel, Bridgette J. McNamara, Rebecca N. Douglas-Denton, Libby Holden, Susan A. Mott, John F. Bertram
Journal: American Journal of Nephrology
Am J Nephrol (2011) 33 (Suppl. 1): 15–20.
https://doi.org/10.1159/000327044
Published Online: 10 June 2011
... in 30 glomeruli in each of 111 adult males who belonged to 4 ethnic groups, i.e. US Whites, African-Americans, Africans from Senegal, and Australian Aborigines. Correlations of pooled IGV values with certain subject characteristics were evaluated in the US Whites. Pooled IGV data were compared...
View articletitled, Distribution of Volumes of Individual Glomeruli in Kidneys at Autopsy: Association with Physical and Clinical Characteristics and with Ethnic Group
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Journal Articles

Genome-Wide Association Scan for Survival on Dialysis in African-Americans with Type 2 Diabetes

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Subject Area:
Topic Article Package: Diabetes , Nephrology
Mariana Murea, Lingyi Lu, Lijun Ma, Pamela J. Hicks, Jasmin Divers, Caitrin W. McDonough, Carl D. Langefeld, Donald W. Bowden, Barry I. Freedman
Journal: American Journal of Nephrology
Am J Nephrol (2011) 33 (6): 502–509.
https://doi.org/10.1159/000327985
Published Online: 05 May 2011
...Mariana Murea; Lingyi Lu; Lijun Ma; Pamela J. Hicks; Jasmin Divers; Caitrin W. McDonough; Carl D. Langefeld; Donald W. Bowden; Barry I. Freedman Background: African-Americans (AAs) with diabetes have high incidence rates of end-stage renal disease (ESRD) with associated high mortality. Genetic...
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Journal Articles

CYP3A4 and CYP3A5 Polymorphisms and Blood Pressure Response to Amlodipine among African-American Men and Women with Early Hypertensive Renal Disease

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Subject Area:
Nephrology
Vibha Bhatnagar, Erin P. Garcia, Daniel T. O’Connor, Victoria H. Brophy, John Alcaraz, Erin Richard, George L. Bakris, John P. Middleton, Keith C. Norris, Jackson Wright, Leena Hiremath, Gabriel Contreras, Lawrence J. Appel, Michael S. Lipkowitz
Journal: American Journal of Nephrology
Am J Nephrol (2010) 31 (2): 95–103.
https://doi.org/10.1159/000258688
Published Online: 12 November 2009
... and CYP3A5 gene polymorphisms and blood pressure response to amlodipine among participants from the African-American Study of Kidney Disease and Hypertension Trial randomized to amlodipine (n = 164). Methods: Cox proportional hazards models were used to determine the risk of reaching a target mean arterial...
View articletitled, CYP3A4 and CYP3A5 Polymorphisms and Blood Pressure Response to Amlodipine among African-American Men and Women with Early Hypertensive Renal Disease
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Journal Articles

Predictors of Hyperkalemia Risk following Hypertension Control with Aldosterone Blockade

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Subject Area:
Nephrology
Nitin Khosla, Rigas Kalaitzidis, George L. Bakris
Journal: American Journal of Nephrology
Am J Nephrol (2009) 30 (5): 418–424.
https://doi.org/10.1159/000237742
Published Online: 09 September 2009
... studied was 64.9 ± 10.7 years, all were obese and 86% had type 2 diabetes, with 82% being African-American. Addition of aldosterone antagonism yielded a further mean reduction in systolic BP of 14.7 ± 5.1 mm Hg (p = 0.001). Females with BMI >30 and those with a baseline systolic BP >160 mm Hg were...
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Journal Articles

Association Analysis of the Ephrin-B2 Gene in African-Americans with End-Stage Renal Disease

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Subject Area:
Nephrology
Pamela J. Hicks, Jennifer L. Staten, Nicholette D. Palmer, Carl D. Langefeld, Julie T. Ziegler, Keith L. Keene, Michele M. Sale, Donald W. Bowden, Barry I. Freedman
Journal: American Journal of Nephrology
Am J Nephrol (2008) 28 (6): 914–920.
https://doi.org/10.1159/000141934
Published Online: 26 June 2008
.... African-Americans End-stage renal disease Ephrin Genetics Hypertensive nephrosclerosis National Institutes of Health (NIH) 10.13039/100000002 Familial aggregation of end-stage renal disease (ESRD) is observed worldwide [ 1 ] and is independent from the prevalence of diabetes...
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