...Meichu Cheng; Hong Liu; Dongshan Zhang; Yinghong Liu; Chang Wang; Fuyou Liu; Junxiang Chen Background/Aims: Advanced glycation end products (AGEs) induce epithelial mesenchymal transition (EMT) in renal proximal tubular epithelial cells (PTECs) by promoting the two EMT regulators, transforming...

...Mengli Tong; Yuhui Wang; Yongjun Wang; Hongyu Chen; Chengda Wang; Luchun Yang; Jonas Axelsson; Bengt Lindholm Objective: To investigate the effect of advanced glycation end products (AGEs) on the expression of connective tissue growth factor (CTGF) and fibronectin (FN) in human peritoneal...

...Melinda T. Coughlan; Sheila K. Patel; George Jerums; Sally A. Penfold; Tuong-Vi Nguyen; Karly C. Sourris; Sianna Panagiotopoulos; Piyush M. Srivastava; Mark E. Cooper; Louise M. Burrell; Richard J. MacIsaac; Josephine M. Forbes Background/Aims: The formation of advanced glycation end products (AGEs...

...Christiane Rüster; Sybille Franke; Ulrich Wenzel; Robin Schmidthaupt; Christoph Fraune; Christian Krebs; Gunter Wolf Background/Aims: The interaction of ‘advanced glycation end products’ (AGEs) and their receptor ‘RAGE’ plays an important role in diabetic nephropathy. We have previously found...

...Melinda T. Coughlan; Josephine M. Forbes Background/Aims: Advanced glycation end products (AGEs) mediate progressive tissue damage in diabetic nephropathy; however, their utility as a noninvasive reliable biomarker of progressive diabetic nephropathy remains to be determined. In this study, we...

...Mansi Dalal; Richard D. Semba; Kai Sun; Candace Crasto; Ravi Varadhan; Stefania Bandinelli; Jeffrey C. Fink; Jack M. Guralnik; Luigi Ferrucci Background/Aims: The relationship of circulating endogenous secretory receptor for advanced glycation end products (esRAGE) and chronic kidney disease (CKD...

...Tzvetanka Bondeva; Gunter Wolf Background: Neuropilin-1 (NRP1) is a transmembrane glycoprotein, initially defined as a receptor for members of the semaphorin family. We observed that NRP1 expression was downregulated by the addition of advanced glycation end products-modified bovine serum albumin...

...Karly C. Sourris; Brooke E. Harcourt; Josephine M. Forbes A commonality among the chemically disparate compounds that inhibit the formation and accumulation of advanced glycation end products (AGEs) or their signalling pathways is their end organ protection in experimental models of diabetes...

...Christiane Rüster; Tzvetanka Bondeva; Sybille Franke; Nobushige Tanaka; Hiroshi Yamamoto; Gunter Wolf Background: Advanced glycation end products (AGEs) play an important role in diabetic nephropathy. The receptor for AGEs, called RAGE, is present on podocytes. We investigated whether angiotensin...

... that advanced glycation end products (AGEs) induced apoptosis in podocytes during the early stage of diabetic nephropathy. However, the mechanism for AGEs to trigger apoptosis of podocytes remains to be elucidated. Apoptotic pathways are activated by a diverse array of extrinsic and intrinsic signals. Early...

...Kentaro Taki; Yoshinari Tsuruta; Toshimitsu Niwa Background: Cardiac troponin T (cTnT) is used as a biomarker of myocardial damage for the diagnosis of acute myocardial infarction and acute coronary syndrome. The aim was to investigate the association between advanced glycation end products (AGEs...

... Serum creatinine Urinary transforming growth factor-beta 1 Advanced glycation end products Phase 2 clinical studies, pyridoxamine Currently established therapeutics for risk reduction in diabetic nephropathy (DN) are primarily antihypertensives, such as the angiotensin-converting enzyme...

... such as transforming growth factor (TGF)-β1, insulin-like growth factor-1 [ 4 ], vascular endothelial growth factor (VEGF), and platelet-derived growth factor (PDGF) [ 5 ], likely to contribute to intimal hyperplasia. Significant local immunostaining for a common advanced glycation end product (AGE...

...İsmail Türker Köksal; Mustafa Faruk Usta; Gökhan Akkoyunlu; Behiye Toptaş; Kemal Hakan Gülkesen; Tibet Erdogru; Murat Tuncer; Aslı Baykal; Fevzi Ersoy; Ramazan Demir; Mehmet Baykara Objectives: To investigate the impact of advanced glycation end products (AGEs) and inducible nitric oxide synthase...