Low doses of dopamine are known to increase renal blood flow without influencing heart rate or systemic blood pressure. Indeed this effect was observed in 32 patients with IgA glomerulopathy. A concomitant increase in glomerular filtration rate (GFR), however, was only observed in patients with a baseline GFR ≥ 73 ml/min/1.73 m2. Moreover, the change in GFR during dopamine infusion increased with increasing baseline GFR. We conclude that in IgA glomerulopathy nephron loss is compensated for by a progressive utilization of the kidney’s functional reserve capacity which seems exhausted when compensated GFR falls below 73 ml/min/1.73 m2.

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