Background: Receipt of nephrology care prior to end-stage renal disease (ESRD) is a strong predictor of decreased mortality and morbidity, and neighborhood poverty may influence access to care. Our objective was to examine whether neighborhood poverty is associated with lack of pre-ESRD care at dialysis facilities. Methods: In a multi-level ecological study using geospatially linked 2007-2010 Dialysis Facility Report and 2006-2010 American Community Survey data, we examined whether high neighborhood poverty (≥20% of households in census tract living below poverty) was associated with dialysis facility-level lack of pre-ESRD care (percentage of patients with no nephrology care prior to dialysis start) in mixed-effects models, adjusting for facility and neighborhood confounders and allowing for neighborhood and regional random effects. Results: Among the 5,184 facilities examined, 1,778 (34.3%) were located in a high-poverty area. Lack of pre-ESRD care was similar in poverty areas (30.8%) and other neighborhoods (29.6%). With adjustment, the absolute increase in percentage of patients at a facility with no pre-ESRD care associated with facility location in a poverty area versus other neighborhood was only 0.08% (95% CI -1.32, 1.47; p = 0.9). Potential effect modification by race and income inequality was detected. Conclusion: Despite previously reported detrimental effects of neighborhood poverty on health, facility neighborhood poverty was not associated with receipt of pre-ESRD care, suggesting no need to target interventions to increase access to pre-ESRD care at facilities in poorer geographic areas.

1.
US Renal Data System, USRDS 2013 Annual Data Report: Atlas of End-Stage Renal Disease in the United States, National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda 2013.
2.
Astor BC, Eustace JA, Powe NR, Klag MJ, Sadler JH, Fink NE, et al: Timing of nephrologist referral and arteriovenous access use: the CHOICE Study. Am J Kidney Dis 2001;38:494-501.
3.
Avorn J, Winkelmayer WC, Bohn RL, Levin R, Glynn RJ, Levy E, et al: Delayed nephrologist referral and inadequate vascular access in patients with advanced chronic kidney failure. J Clin Epidemiol 2002;55:711-716.
4.
Winkelmayer WC, Glynn RJ, Levin R, Owen W Jr, Avorn J: Late referral and modality choice in end-stage renal disease. Kidney Int 2001;60:1547-1554.
5.
Winkelmayer WC, Glynn RJ, Levin R, Mittleman MA, Pliskin JS, Avorn J: Late nephrologist referral and access to renal transplantation. Transplantation 2002;73:1918-23.
6.
Winkelmayer WC, Owen WF Jr, Levin R, Avorn J: A propensity analysis of late versus early nephrologist referral and mortality on dialysis. J Am Soc Nephrol 2003;14:486-492.
7.
Kinchen KS, Sadler J, Fink N, Brookmeyer R, Klag MJ, Levey AS, et al: The timing of specialist evaluation in chronic kidney disease and mortality. Ann Intern Med 2002;137:479-486.
8.
Stack AG: Impact of timing of nephrology referral and pre-ESRD care on mortality risk among new ESRD patients in the United States. Am J Kidney Dis 2003;41:310-318.
9.
Kazmi WH, Obrador GT, Khan SS, Pereira BJ, Kausz AT: Late nephrology referral and mortality among patients with end-stage renal disease: a propensity score analysis. Nephrol Dial Transplant 2004;19:1808-1814.
10.
Hasegawa T, Bragg-Gresham JL, Yamazaki S, Fukuhara S, Akizawa T, Kleophas W, et al: Greater first-year survival on hemodialysis in facilities in which patients are provided earlier and more frequent pre-nephrology visits. Clin J Am Soc Nephrol 2009;4:595-602.
11.
McClellan WM, Wasse H, McClellan AC, Kipp A, Waller LA, Rocco MV: Treatment center and geographic variability in pre-ESRD care associate with increased mortality. J Am Soc Nephrol 2009;20:1078-1085.
12.
Bishaw A: Areas with concentrated poverty: 2006-2010. American Community Survey Briefs. Suitland/MD, US Census Bureau, December 2011.
13.
Sen A, Foster JE: On Economic Inequality, expanded ed. Oxford, Clarendon Press, 1997.
14.
Bruce MA, Beech BM, Crook ED, Sims M, Wyatt SB, Flessner MF, et al: Association of socioeconomic status and CKD among African-Americans: the Jackson Heart Study. Am J Kidney Dis 2010;55:1001-1008.
15.
Crews DC, Charles RF, Evans MK, Zonderman AB, Powe NR: Poverty, race, and CKD in a racially and socioeconomically diverse urban population. Am J Kidney Dis 2010;55:992-1000.
16.
Hall YN, Choi AI, Chertow GM, Bindman AB: Chronic kidney disease in the urban poor. Clin J Am Soc Nephrol 2010;5:828-835.
17.
Fored CM, Ejerblad E, Fryzek JP, Lambe M, Lindblad P, Nyren O, et al: Socio-economic status and chronic renal failure: a population-based case-control study in Sweden. Nephrol Dial Transplant 2003;18:82-88.
18.
White SL, McGeechan K, Jones M, Cass A, Chadban SJ, Polkinghorne KR, et al: Socioeconomic disadvantage and kidney disease in the United States, Australia, and Thailand. Am J Public Health 2008;98:1306-1313.
19.
Hossain MP, Goyder EC, Rigby JE, El Nahas M: CKD and poverty: a growing global challenge. Am J Kidney Dis 2009;53:166-174.
20.
Young BA: The interaction of race, poverty, and CKD. Am J Kidney Dis 2010;55:977-980.
21.
Thamer M, Henderson SC, Ray NF, Rinehart CS, Greer JW, Danovitch GM: Unequal access to cadaveric kidney transplantation in California based on insurance status. Health Serv Res 1999;34:879-900.
22.
Butkus DE, Dottes AL, Meydrech EF, Barber WH: Effect of poverty and other socioeconomic variables on renal allograft survival. Transplantation 2001;72:261-266.
23.
McClellan WM, McClellan CB: Poverty and mortality in hemodialysis patients. J Am Soc Nephrol 2013;24:165-167.
24.
Merkin SS, Coresh J, Roux AV, Taylor HA, Powe NR: Area socioeconomic status and progressive CKD: the Atherosclerosis Risk in Communities (ARIC) Study. Am J Kidney Dis 2005;46:203-213.
25.
Merkin SS, Diez Roux AV, Coresh J, Fried LF, Jackson SA, Powe NR: Individual and neighborhood socioeconomic status and progressive chronic kidney disease in an elderly population: The Cardiovascular Health Study. Soc Sci Med 2007;65:809-821.
26.
McClellan WM, Newsome BB, McClure LA, Howard G, Volkova N, Audhya P, et al: Poverty and racial disparities in kidney disease: the REGARDS study. Am J Nephrol 2010;32:38-46.
27.
Volkova N, McClellan W, Klein M, Flanders D, Kleinbaum D, Soucie JM, et al: Neighborhood poverty and racial differences in ESRD incidence. J Am Soc Nephrol 2008;19:356-364.
28.
Patzer RE, Amaral S, Wasse H, Volkova N, Kleinbaum D, McClellan WM: Neighborhood poverty and racial disparities in kidney transplant waitlisting. J Am Soc Nephrol 2009;20:1333-1340.
29.
Hall YN, O'Hare AM, Young BA, Boyko EJ, Chertow GM: Neighborhood poverty and kidney transplantation among US Asians and Pacific Islanders with end-stage renal disease. Am J Transplant 2008;8:2402-2409.
30.
Kanda E, Erickson K, Bond TC, Krisher J, McClellan WM: Hemodialysis treatment center early mortality rates for incident hemodialysis patients are associated with the quality of care prior to starting but not following onset of dialysis. Am J Nephrol 2011;33:390-397.
31.
Holt JB: The topography of poverty in the United States: a spatial analysis using county-level data from the Community Health Status Indicators project. Prev Chronic Dis 2007;4:A111.
32.
McClellan WM, Wasse H, McClellan AC, Holt J, Krisher J, Waller LA: Geographic concentration of poverty and arteriovenous fistula use among ESRD patients. J Am Soc Nephrol 2010;21:1776-1782.
33.
Krieger N, Chen JT, Waterman PD, Soobader MJ, Subramanian SV, Carson R: Geocoding and monitoring of US socioeconomic inequalities in mortality and cancer incidence: does the choice of area-based measure and geographic level matter? The Public Health Disparities Geocoding Project. Am J Epidemiol 2002;156:471-482.
34.
Stafford M, Duke-Williams O, Shelton N: Small area inequalities in health: are we underestimating them? Soc Sci Med 2008;67:891-899.
35.
Flowerdew R, Manley DJ, Sabel CE: Neighbourhood effects on health: does it matter where you draw the boundaries? Soc Sci Med 2008;66:1241-1255.
36.
Haynes R, Daras K, Reading R, Jones A: Modifiable neighbourhood units, zone design and residents' perceptions. Health Place 2007;13:812-825.
37.
Maripuri S, Ikizler TA, Cavanaugh KL: Prevalence of pre-end-stage renal disease care and associated outcomes among urban, micropolitan, and rural dialysis patients. Am J Nephrol 2013;37:274-280.
38.
Yan G, Cheung AK, Ma JZ, Yu AJ, Greene T, Oliver MN, et al: The associations between race and geographic area and quality-of-care indicators in patients approaching ESRD. Clin J Am Soc Nephrol 2013;8:610-618.
39.
Lynch JR, Mohan S, McClellan WM: Achieving the goal: results from the Fistula First Breakthrough Initiative. Curr Opin Nephrol Hypertens 2011;20:583-592.
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