Background: In acute meningitis hyponatremia is common and traditionally attributed exclusively to inappropriate water retention. However, the exact mechanisms underlying hyponatremia are unknown. Methods: The files of 300 pediatric patients with acute bacterial (n = 190) or aseptic (n = 110) meningitides were retrospectively analyzed. Results: The plasma sodium level ranged from 122 to 148 mmol/l and was low (<133 mmol/l) in 97 patients. Fluid volume contraction was significantly more pronounced in hyponatremia (median 6.0 · 10–2) than in normonatremia (median 2.0 · 10–2). The fractional sodium excretion was less than 1.00 · 10–2 in the 26 hyponatremic children with this measurement. Conclusion: In acute meningitis hyponatremia is not exclusively brought about by inappropriate water retention.

Keywords:
Childhood, Fluid therapy, Hyponatremia, Meningitis
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© 2001 S. Karger AG, Basel
2001
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