These studies were designed to test the accuracy of measures of the duration of the preejection period (PEP), left ventricular ejection time (LVET) and total electromechanical systole (TES) derived from the electrocardiographically gated nuclear ventriculographic curve. Comparisons were made with measurements of the same intervals obtained by conventional graphics recording of the electrocardiogram, phonocardiogram, and carotid arterial pulse. The recording of the nucleographic gate signal simultaneous with the graphics recordings permitted synchronization of the temporal events by the two methods. Among 10 normal subjects and 40 patients with coronary artery disease, a high correlation between the nuclear and conventional graphics methods was observed for PEP and TES (r = 0.92), while a lesser but close correlation was observed for LVET and PEP/LVET (r = 0.84 and r = 0.83). There was no significant systematic difference between the methods for the duration of PEP, LVET, TES, or in the PEP/LVET. The mean rate of left ventricular ejection (MRE) calculated from the ratio of the left ventricular ejection fraction(LVEF) to the nucleographic LVET (LVEF/LVET) correlated highly with LVEF and the maximum rate of left ventricular ejection (r = 0.98, r = 0.99). The close parallelism between LVEF and the mean and maximum rates of ejection suggests that these measures may be interchangeable in the clinical assessment of global left ventricular function.

Keywords:
Gated radionuclide ventriculography, Systolic time intervals, Left ventricular function, Myocardial infarction
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1992
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