Analysis of multiple variables alone and in combination were evaluated in a cohort of 300 men who had exercise testing and coronary angiography. We found that when a study was not restricted to just those with a history of chest pain, the sensitivity and specificity of exercise testing was reduced; although ST depression had the best sensitivity. The specificity was better when using ST/HR slope 6 mV/B, R wave increase of 2 mm, typical angina during the test, heart rate less than 40, and an exercise time less than 4 min. When variables are used together, the specificity increases, the sensitivity decreases, and fewer of the patients tested can be included in the analysis.

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