...Christiane Delbrück; Wolfgang Miesbach Introduction: Women with von Willebrand disease (VWD) are at a higher risk of bleeding, which might affect the health of mother and child during pregnancy and the intra- and postpartum periods. This retrospective cohort study evaluates changes...

...David McLaughlin; Ron Kerr Type 2B von Willebrand disease is a rare bleeding condition resulting in thrombocytopenia and a reduction in large VWF multimers. It usually has an autosomal dominant pattern of inheritance. We report the management of a patient with type 2B von Willebrand disease, whose...

... congenital bleeding disorders, e.g. von Willebrand disease, presenting with menorrhagia. The challenges of diagnosis and treatment of either thrombosis or bleeding disorders in young adults will be discussed in this review. orly.katz@sheba.gov.il 10 9 2014 © 2014 S. Karger AG, Basel 2014...

...Cedric Hermans; Javier Batlle von Willebrand disease (VWD) type 2M is a distinct entity and clearly differs from type 1. The genotype-phenotype correlation for cases with ristocetin cofactor activity (RCo)/antigen (Ag) ratios <0.60 is clear, whereas the von Willebrand factor (VWF):collagen...

...), collagen binding (CB) and antigen concentration (Ag), ristocetin-induced platelet aggregation (RIPA) and multimeric analysis of VWF in low and medium SDS-agarose resolution gels, is warranted to diagnose and classify all variants of von Willebrand disease (VWD). VWD type 2M and 2U are typically...

...Alain Gadisseur; Zwi Berneman; Wilfried Schroyens; Jan Jacques Michiels Autosomal dominant von Willebrand disease (VWD) type 1/2E is a quantitative/qualitative defect in the von Willebrand factor (VWF) caused by heterozygous cysteine and non-cysteine mutations in the D3 domain of the VWF gene...