...Murat Twicer; Seppo Pakkala Expression of p53 oncogene in blast cells may have prognostic importance in acute leukemia. Simple and reliable methods which could detect enhanced p53 expression in leukemia cells would be important for follow-up studies of leukemia patients in remission. We used...

...Gianluca Brusa; Manuela Mancini; Fabio Campanini; Alberto Calabrò; Elisa Zuffa; Enza Barbieri; Maria Alessandra Santucci In order to ascertain whether p53 has a role in chronic myeloid leukemia hematopoietic progenitor response to the innovative tyrosine kinase inhibitor STI571 (Imatinib), we...

... myelogenous leukemia (AML) and 13 patients with de novo AML. In addition, we investigated the relationship of apoptosis to the immunohistochemical expression of bcl -2 and p53 in these cases, and the association of apoptosis, bcl -2, and p53 with the leukemic evolution of MDS by examining sequential bone...

...Anita Boyapati; Eiki Kanbe; Dong-Er Zhang Although most solid tumors contain inactivating mutations of the p53 tumor suppressor, hematological malignancies do not contain frequent alterations in the p53 gene (<20%). How these tumors arise in the presence of a super tumor suppressor like p53...

...K.B.B. Pagnano; M.D. Silva; J. Vassallo; F.J.P. Aranha; S.T.O. Saad We evaluated the expression of apoptosis-regulating proteins (p53, Bcl-2, Bax, Bak and Mcl-1) in paraffin-embedded tissues of 33 patients with diffuse large B cell non-Hodgkin’s lymphoma , and assessed the relationship...

... with acute myeloid leukaemia (AML) and in 7 normal controls. Using flow cytometry and immunocytochemistry, we demonstrated that patients with AML had a high expression of iNOS when compared to controls. There was no correlation between the expression of iNOS and the expression of p53 and K, H, and N-ras...

... alternating with spontaneous remission. In the present study, we examined the involvement of apoptosis-related proteins in the progression of this cyclic lymphoma ex vivo. During the leukemic phases, the clonal cells were activated blasts expressing elevated levels of wild-type (wt) p53, Bcl-2, Bcl-x L...

...A. Zheng; P. Mäntymaa; M. Säily; E.-R. Savolainen; K. Vähäkangas; P. Koistinen The role of the p53 pathway in apoptosis induced by all- trans -retinoic acid (ATRA) was studied in 5 human acute myeloid leukaemia (AML) cell lines, OU-AML-3, -4, -5, -7 and -8, previously established and characterized...

...) containing the p53 tumor suppressor gene (Adv-p53) has been suggested to reduce tumor contamination of autologous stem cell product. We demonstrate herein a safe and effective Adv-p53 purging procedure using four human breast cancer TC lines. Multiple parameters need to be achieved to successfully purge stem...