...Hiromitsu Matsuzaki; Hiroyuki Hata; Norio Asou; Hitoshi Suzushima; Yoshitaka Akahoshi; Minoru Yoshida; Shouichi Nagakura; Toshinori Ishii; Isao Sanada; Kiyoshi Takatsuki Cell line KHM-2B expressing two oncogene products, c-myc and bcl-2, was established from a patient with actute lymphocytic...

...C.Y. Zheng; P. Pabello; L.F. Skinnider The bcl-2 gene product inhibits apoptosis and thus its over-expression may promote development of the malignant phenotype under certain circumstances. We have introduced the bcl-2α and bcl-2β genetic elements into T cell acute lymphoblastic leukemic blasts...

... myelogenous leukemia (AML) and 13 patients with de novo AML. In addition, we investigated the relationship of apoptosis to the immunohistochemical expression of bcl -2 and p53 in these cases, and the association of apoptosis, bcl -2, and p53 with the leukemic evolution of MDS by examining sequential bone...

..., underlies a number of disease states. Bcl-2 family proteins play a key role in regulating cell death and survival, and a number of studies have demonstrated their role as important regulators of cell fate in the lymphoid system. Mice that are genetically deficient or overexpress various Bcl-2 family...

...Nele Festjens; Marjan van Gurp; Geert van Loo; Xavier Saelens; Peter Vandenabeele In addition to their function as major energy-providing organelles of the cell, mitochondria accomplish a crucial role in apoptosis. The pro-apoptotic BH3-only members of the Bcl-2 family continuously sense...

... maturation at which defects in PCD arise and the underlying causes of apoptosis dysregulation remain unknown. This paper outlines the apoptotic process in normal hematopoietic cells and summarizes current data regarding the role, potential causes and clinical implications of altered apoptosis in MDS. Bcl-2...

..., that CD95 and CD95 ligand (CD95L) expression was upregulated, caspase 8 and caspase 3 were activated, and Bcl-2 protein expression was downregulated. On the other hand, in K562, the cell cycle was arrested at the G2+M phase, CD95/CD95L expression was upregulated, caspase 8 and caspase 3 were activated...

...K.B.B. Pagnano; M.D. Silva; J. Vassallo; F.J.P. Aranha; S.T.O. Saad We evaluated the expression of apoptosis-regulating proteins (p53, Bcl-2, Bax, Bak and Mcl-1) in paraffin-embedded tissues of 33 patients with diffuse large B cell non-Hodgkin’s lymphoma , and assessed the relationship...

... detectable in flow cytometry by PAb 240, but not by PAb 1620 (an antibody which only detects p53 in wt conformation). At the same time bcl-2 was down-regulated as shown by Western blotting and flow cytometry, while no induction of bax was observed by ATRA. On the basis of these results, ATRA-induced...

... or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. bcl-2 B lymphoid leukemia Chronic lymphocytic leukemia Hairy cell leukemia...