...S. Galimberti; B. Nagy; G.A. Palumbo; E. Ciancia; G. Buda; E. Orciuolo; A. Melosi; P. Lambelet; F. Ronca; M. Petrini In this study, we determined the allele and genotype frequencies of vascular endothelial growth factor (VEGF) G+405C, C–460T , C+936T and C–2578A single nucleotide polymorphisms...

...P.P. Landburg; H. Elsenga; J.B. Schnog; A.J. Duits The anti-angiogenic factors soluble fms-like tyrosine kinase (sFlt)-1 and soluble endoglin (sEng) have been shown to be of importance in angiogenesis by sequestering and inhibiting vascular endothelial growth factor, placenta-like growth factor...

... stimulator, the vascular endothelial growth factor (VEGF), in polycythaemia vera (PV). We report our observation of elevated serum VEGF levels in patients suffering from PV. Twenty patients with PV and 20 age-matched healthy subjects were enrolled. VEGF levels were measured by a quantitative sandwich enzyme...

... of TGF-β signalling are responsible for HHT. An additional role for vascular endothelial growth factor (VEGF) has been proposed. Serum VEGF, which has been evaluated in several diseases characterized by aberrant angiogenesis, has never been measured in patients with HHT. Aims: To evaluate VEGF serum...

... the importance of angiogenesis in hematological malignancies including leukemia, lymphoma, and multiple myeloma. Expression of angiogenic polypeptides vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) correlate with clinical characteristics in leukemia and lymphoma...

... them a promising activity both in vitro and in animal models has been displayed by thalidomide analogs, inhibitors of vascular endothelial growth factor receptor-2 and endostatin. Table 1 Single agent thalidomide in relapsed/refractory MM 24 1 2002 © 2001 S. Karger AG, Basel...

...Napoleone Ferrara; Hans-Peter Gerber Vascular endothelial growth factor (VEGF) is an endothelial cell-specific mitogen and an angiogenic inducer as well as a mediator of vascular permeability. The biological effects of VEGF are mediated by two tyrosine kinase receptors, Flt-1 (VEGFr-1) and KDR...

... with a substantial increase in vascularity in the bone marrow as well as increased levels of various angiogenic factors including vascular endothelial growth factor (VEGF), basic fibroblast growth factor, angiogenin, angiopoietin-1, platelet-derived growth factor, hepatocyte growth factor, epidermal growth factor...

.... Angiogenesis Leukemia Vascular endothelial growth factor In the early 1970s, the relevance of tumor-associated angiogenesis was recognized. The fundamental elements of neovascularization and the mechanisms by which tumor cells invade and metastasize have been further characterized, particularly...